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Murcko scaffold

Ring system with 4 rings and 23 atoms

32 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
32
With full pages
1
Scaffold SMILES

O=c1ccn(-c2ccccc2)c2nc(N3CCNCC3)ccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccn(-c2ccccc2)c2nc(N3CCNCC3)ccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)- chemical structure, C19H15F3N4O3, CAS 100490-19-5
1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
CAS 100490-19-5C19H15F3N4O3
1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C20H17F3N4O3, CAS 100490-72-0
1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-72-0C20H17F3N4O3
1-(2,4-Difluorophenyl)-7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C21H19F3N4O3, CAS 182869-25-6
1-(2,4-Difluorophenyl)-7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 182869-25-6C21H19F3N4O3
1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo- chemical structure, C21H19F3N4O3, CAS 182869-27-8
1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-
CAS 182869-27-8C21H19F3N4O3
6-Fluoro-4-oxo-1-phenyl-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid chemical structure, C19H17FN4O3, CAS 100426-72-0
6-Fluoro-4-oxo-1-phenyl-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
CAS 100426-72-0C19H17FN4O3
Ethyl 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H22F2N4O3, CAS 100491-52-9
Ethyl 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 100491-52-9C22H22F2N4O3
Ethyl 6-fluoro-1-(4-fluorophenyl)-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H22F2N4O3, CAS 100546-84-7
Ethyl 6-fluoro-1-(4-fluorophenyl)-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 100546-84-7C22H22F2N4O3
Ethyl 6-fluoro-1-(4-fluorophenyl)-7-(4-(2-hydroxyethyl)piperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C23H24F2N4O4, CAS 100491-55-2
Ethyl 6-fluoro-1-(4-fluorophenyl)-7-(4-(2-hydroxyethyl)piperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 100491-55-2C23H24F2N4O4
Ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H21F3N4O3, CAS 100491-63-2
Ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 100491-63-2C22H21F3N4O3
Ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate chemical structure, C22H21F3N4O3, CAS 100492-07-7
Ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
CAS 100492-07-7C22H21F3N4O3
6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C19H16F2N4O3, CAS 100490-21-9
6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-21-9C19H16F2N4O3
6-Fluoro-1-(3-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C19H16F2N4O3, CAS 100490-22-0
6-Fluoro-1-(3-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-22-0C19H16F2N4O3
6-Fluoro-1-(2-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C19H16F2N4O3, CAS 100490-23-1
6-Fluoro-1-(2-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-23-1C19H16F2N4O3
1-(3,4-Difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C19H15F3N4O3, CAS 100490-24-2
1-(3,4-Difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-24-2C19H15F3N4O3
1-(2,5-Difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C19H15F3N4O3, CAS 100490-26-4
1-(2,5-Difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-26-4C19H15F3N4O3
1-(2,6-Difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C19H15F3N4O3, CAS 100490-27-5
1-(2,6-Difluorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-27-5C19H15F3N4O3
1-(4-Chloro-phenyl)-6-fluoro-4-oxo-7-piperazin-1-YL-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid chemical structure, C19H16ClFN4O3, CAS 100490-28-6
1-(4-Chloro-phenyl)-6-fluoro-4-oxo-7-piperazin-1-YL-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
CAS 100490-28-6C19H16ClFN4O3
6-Fluoro-1-(4-fluoro-2-methylphenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C20H18F2N4O3, CAS 100490-35-5
6-Fluoro-1-(4-fluoro-2-methylphenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-35-5C20H18F2N4O3
1-(2,4-Difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C20H17F3N4O3, CAS 100490-71-9
1-(2,4-Difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-71-9C20H17F3N4O3
6-Fluoro-1-(4-fluoro-2-hydroxyphenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C19H16F2N4O4, CAS 100490-52-6
6-Fluoro-1-(4-fluoro-2-hydroxyphenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-52-6C19H16F2N4O4
6-Fluoro-1-(4-fluoro-2-hydroxyphenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C20H18F2N4O4, CAS 100490-53-7
6-Fluoro-1-(4-fluoro-2-hydroxyphenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-53-7C20H18F2N4O4
6-Fluoro-1-(3-fluoro-4-hydroxyphenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C20H18F2N4O4, CAS 100490-54-8
6-Fluoro-1-(3-fluoro-4-hydroxyphenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-54-8C20H18F2N4O4
6-Fluoro-1-(2-fluoro-4-hydroxyphenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C20H18F2N4O4, CAS 100490-56-0
6-Fluoro-1-(2-fluoro-4-hydroxyphenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-56-0C20H18F2N4O4
6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C20H18F2N4O3, CAS 100490-64-0
6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS 100490-64-0C20H18F2N4O3