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Murcko scaffold

Ring system with 4 rings and 22 atoms

37 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 37
With full pages: 1

Scaffold SMILES

c1ccc(C2CCN(Cc3c[nH]c4ccccc34)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(C2CCN(Cc3c[nH]c4ccccc34)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 37 of 37 chemicals

Isonipecotic acid, 1-(5-nitro-3-indolylmethyl)-4-phenyl-, ethyl ester, hydrochloride chemical structure, C23H26ClN3O4, CAS 3414-73-1

Isonipecotic acid, 1-(5-nitro-3-indolylmethyl)-4-phenyl-, ethyl ester, hydrochloride

CAS 3414-73-1C₂₃H₂₆ClN₃O₄

4-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol chemical structure, C20H21ClN2O, CAS 81226-60-0

4-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol

CAS 81226-60-0C₂₀H₂₁ClN₂O

4-Piperidinol, 1-(1H-indol-3-ylmethyl)-4-phenyl- chemical structure, C20H22N2O, CAS 81226-62-2

4-Piperidinol, 1-(1H-indol-3-ylmethyl)-4-phenyl-

CAS 81226-62-2C₂₀H₂₂N₂O

3-{[4-(2-Methoxyphenyl)piperidino]methyl}-2-methyl-1H-indole chemical structure, C22H26N2O, CAS 700843-95-4

3-{[4-(2-Methoxyphenyl)piperidino]methyl}-2-methyl-1H-indole

CAS 700843-95-4C₂₂H₂₆N₂O

4-Piperidinemethanol, 4-phenyl-1-(5-methoxy-3-indolylmethyl)-, hydrochloride chemical structure, C22H27ClN2O2, CAS 102071-32-9

4-Piperidinemethanol, 4-phenyl-1-(5-methoxy-3-indolylmethyl)-, hydrochloride

CAS 102071-32-9C₂₂H₂₇ClN₂O₂

1H-Indole-2-methanol, 3-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]- chemical structure, C21H22Cl2N2O, CAS 827015-94-1

1H-Indole-2-methanol, 3-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-

CAS 827015-94-1C₂₁H₂₂Cl₂N₂O

1H-Indole, 3-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]- chemical structure, C20H20Cl2N2, CAS 82211-91-4

1H-Indole, 3-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-

CAS 82211-91-4C₂₀H₂₀Cl₂N₂

1H-Indole, 3-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-2-methyl- chemical structure, C21H22Cl2N2, CAS 827014-96-0

1H-Indole, 3-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-2-methyl-

CAS 827014-96-0C₂₁H₂₂Cl₂N₂

1H-Indole-1-ethanol, 3-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]- chemical structure, C22H24Cl2N2O, CAS 827016-10-4

1H-Indole-1-ethanol, 3-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-

CAS 827016-10-4C₂₂H₂₄Cl₂N₂O

1H-Indole, 3-[1-[4-(2,6-dimethylphenyl)-1-piperidinyl]ethyl]- chemical structure, C23H28N2, CAS 827015-93-0

1H-Indole, 3-[1-[4-(2,6-dimethylphenyl)-1-piperidinyl]ethyl]-

CAS 827015-93-0C₂₃H₂₈N₂

1H-Indole-1-ethanol, 3-[[4-(2,6-dimethylphenyl)-1-piperidinyl]methyl]- chemical structure, C24H30N2O, CAS 827016-11-5

1H-Indole-1-ethanol, 3-[[4-(2,6-dimethylphenyl)-1-piperidinyl]methyl]-

CAS 827016-11-5C₂₄H₃₀N₂O

1-((5-Methoxy-1H-indol-3-yl)methyl)-4-(4-(methylthio)phenyl)piperidin-4-ol chemical structure, C22H26N2O2S, CAS 873445-73-9

1-((5-Methoxy-1H-indol-3-yl)methyl)-4-(4-(methylthio)phenyl)piperidin-4-ol

CAS 873445-73-9C₂₂H₂₆N₂O₂S

4-(2-Chlorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C20H21ClN2O, CAS 925217-83-0

4-(2-Chlorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925217-83-0C₂₀H₂₁ClN₂O

4-(2,3-Dichlorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C20H20Cl2N2O, CAS 925217-84-1

4-(2,3-Dichlorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925217-84-1C₂₀H₂₀Cl₂N₂O

4-(3-Chlorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C20H21ClN2O, CAS 925217-85-2

4-(3-Chlorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925217-85-2C₂₀H₂₁ClN₂O

4-(3,4-Dichlorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C20H20Cl2N2O, CAS 925217-86-3

4-(3,4-Dichlorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925217-86-3C₂₀H₂₀Cl₂N₂O

1-((1H-Indol-3-yl)methyl)-4-(3-(trifluoromethyl)phenyl)piperidin-4-ol chemical structure, C21H21F3N2O, CAS 925217-87-4

1-((1H-Indol-3-yl)methyl)-4-(3-(trifluoromethyl)phenyl)piperidin-4-ol

CAS 925217-87-4C₂₁H₂₁F₃N₂O

4-(4-Fluorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C20H21FN2O, CAS 925217-88-5

4-(4-Fluorophenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925217-88-5C₂₀H₂₁FN₂O

4-(4-Hydroxyphenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C20H22N2O2, CAS 925217-89-6

4-(4-Hydroxyphenyl)-1-[(1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925217-89-6C₂₀H₂₂N₂O₂

1-((1H-Indol-3-yl)methyl)-4-(4-methoxyphenyl)piperidin-4-ol chemical structure, C21H24N2O2, CAS 925217-90-9

1-((1H-Indol-3-yl)methyl)-4-(4-methoxyphenyl)piperidin-4-ol

CAS 925217-90-9C₂₁H₂₄N₂O₂

4-(4-Chlorophenyl)-1-[(2-methyl-1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C21H23ClN2O, CAS 925218-08-2

4-(4-Chlorophenyl)-1-[(2-methyl-1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925218-08-2C₂₁H₂₃ClN₂O

4-(4-Chlorophenyl)-1-[(1-methyl-1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C21H23ClN2O, CAS 925218-14-0

4-(4-Chlorophenyl)-1-[(1-methyl-1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925218-14-0C₂₁H₂₃ClN₂O

4-(4-Chlorophenyl)-1-[(1-hexyl-1H-indol-3-yl)methyl]piperidin-4-ol chemical structure, C26H33ClN2O, CAS 925218-15-1

4-(4-Chlorophenyl)-1-[(1-hexyl-1H-indol-3-yl)methyl]piperidin-4-ol

CAS 925218-15-1C₂₆H₃₃ClN₂O

1-[(1H-Indol-3-yl)methyl]-4-[4-(methylsulfanyl)phenyl]piperidin-4-ol chemical structure, C21H24N2OS, CAS 873445-71-7

1-[(1H-Indol-3-yl)methyl]-4-[4-(methylsulfanyl)phenyl]piperidin-4-ol

CAS 873445-71-7C₂₁H₂₄N₂OS