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Murcko scaffold

Ring system with 4 rings and 22 atoms

42 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
42
With full pages
2
Scaffold SMILES

c1ccc(-c2ccc(Cn3cnc4ccccc43)cc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ccc(Cn3cnc4ccccc43)cc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

4''-(2-Butyl-6-pentanoylamino-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid chemical structure, C30H33N3O3, CAS 133085-38-8
4''-(2-Butyl-6-pentanoylamino-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid
CAS 133085-38-8C30H33N3O3
Methyl 2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate chemical structure, C25H24N4O4
Methyl 2-ethoxy-1-((2'-(N-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
C25H24N4O4
Tert.butyl 4'-[(2-n-butyl-4-cyano-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate chemical structure, C30H31N3O2, CAS 133140-00-8
Tert.butyl 4'-[(2-n-butyl-4-cyano-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate
CAS 133140-00-8C30H31N3O2
Methyl 2-ethoxy-1-((2'-hydroxy-amidinobiphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylate chemical structure, C25H24N4O4, CAS 147403-65-4
Methyl 2-ethoxy-1-((2'-hydroxy-amidinobiphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylate
CAS 147403-65-4C25H24N4O4
Ethyl 1-((2'-cyano(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1H-benzimidazole-7-carboxylate chemical structure, C26H23N3O3, CAS 139481-41-7
Ethyl 1-((2'-cyano(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1H-benzimidazole-7-carboxylate
CAS 139481-41-7C26H23N3O3
Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-methoxybenzimidazole-7-carboxylate chemical structure, C24H19N3O3, CAS 139481-47-3
Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-methoxybenzimidazole-7-carboxylate
CAS 139481-47-3C24H19N3O3
Methyl 1-((2'-cyano(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1H-benzimidazole-7-carboxylate chemical structure, C25H21N3O3, CAS 139481-44-0
Methyl 1-((2'-cyano(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1H-benzimidazole-7-carboxylate
CAS 139481-44-0C25H21N3O3
Methyl 2-ethoxy-1-[(2'-methoxycarbonylbiphenyl-4-yl)methyl]benzimidazole-7-carboxylate chemical structure, C26H24N2O5, CAS 139481-53-1
Methyl 2-ethoxy-1-[(2'-methoxycarbonylbiphenyl-4-yl)methyl]benzimidazole-7-carboxylate
CAS 139481-53-1C26H24N2O5
Methyl 1-((2'-carbamoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate chemical structure, C25H23N3O4, CAS 147404-76-0
Methyl 1-((2'-carbamoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
CAS 147404-76-0C25H23N3O4
2-Ethoxy-1-[(2'-carboxybiphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid chemical structure, C24H20N2O5, CAS 139482-04-5
2-Ethoxy-1-[(2'-carboxybiphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
CAS 139482-04-5C24H20N2O5
1-((2'-Cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid chemical structure, C24H19N3O3, CAS 632322-61-3
1-((2'-Cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
CAS 632322-61-3C24H19N3O3
1-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid chemical structure, C26H23N3O2, CAS 1098100-87-8
1-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid
CAS 1098100-87-8C26H23N3O2
Methyl 3-[[4-(2-cyanophenyl)phenyl]methyl]-7-methyl-2-propylbenzimidazole-5-carboxylate chemical structure, C27H25N3O2, CAS 1098100-86-7
Methyl 3-[[4-(2-cyanophenyl)phenyl]methyl]-7-methyl-2-propylbenzimidazole-5-carboxylate
CAS 1098100-86-7C27H25N3O2
6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan chemical structure, C26H24N2O4, CAS 884330-12-5
6-Des(1-methyl-2-benzimidazolyl)-6-carboxy Telmisartan
CAS 884330-12-5C26H24N2O4
1-{[2'-(Methoxycarbonyl)[1,1'-biphenyl]-4-yl]methyl}-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid chemical structure, C27H26N2O4, CAS 884330-11-4
1-{[2'-(Methoxycarbonyl)[1,1'-biphenyl]-4-yl]methyl}-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid
CAS 884330-11-4C27H26N2O4
1-([1,1'-Biphenyl]-4-ylmethyl)-4,6-difluoro-5-iodo-2-(methylthio)-1H-benzo[d]imidazole chemical structure, C21H15F2IN2S, CAS 1219741-32-8
1-([1,1'-Biphenyl]-4-ylmethyl)-4,6-difluoro-5-iodo-2-(methylthio)-1H-benzo[d]imidazole
CAS 1219741-32-8C21H15F2IN2S
Ethyl 2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate chemical structure, C26H26N4O4, CAS 1397836-41-7
Ethyl 2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
CAS 1397836-41-7C26H26N4O4
Methyl 2-ethoxy-3-[[4-[2-(N'-hydroxycarbamimidoyl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate chemical structure, C25H24N4O4
Methyl 2-ethoxy-3-[[4-[2-(N'-hydroxycarbamimidoyl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
C25H24N4O4
1-[(2'-Cyano-1,1'-biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylic Acid Methyl Ester chemical structure, C25H21N3O3, CAS 1794783-33-7
1-[(2'-Cyano-1,1'-biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylic Acid Methyl Ester
CAS 1794783-33-7C25H21N3O3
2-Ethoxy-d5-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid Methyl Ester chemical structure, C25H24N4O4, CAS 1795133-18-4
2-Ethoxy-d5-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid Methyl Ester
CAS 1795133-18-4C25H24N4O4
Azilsartan impurity 24 chemical structure, C29H30N4O6, CAS 1403474-75-8
Azilsartan impurity 24
CAS 1403474-75-8C29H30N4O6
1-((2'-Carbamoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid chemical structure, C24H21N3O4, CAS 1696392-11-6
1-((2'-Carbamoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
CAS 1696392-11-6C24H21N3O4
Methyl 1-((2'-carbamimidoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[D]imidazole-7-carboxylate chemical structure, C25H24N4O3, CAS 3023129-68-9
Methyl 1-((2'-carbamimidoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[D]imidazole-7-carboxylate
CAS 3023129-68-9C25H24N4O3
1-((2'-Carbamimidoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid chemical structure, C24H22N4O3, CAS 1442400-65-8
1-((2'-Carbamimidoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
CAS 1442400-65-8C24H22N4O3