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Murcko scaffold

3(2H)-Isoquinolinone, 1,4-dihydro-1,2-diphenyl- scaffold

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
9
With full pages
2
Scaffold SMILES

O=C1Cc2ccccc2C(c2ccccc2)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3(2H)-Isoquinolinone, 1,4-dihydro-1,2-diphenyl- page
Murcko scaffold O=C1Cc2ccccc2C(c2ccccc2)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

4-(6,7-Dimethoxy-1-(4-methoxyphenyl)-3-oxo-3,4-dihydro-2(1H)-isoquinolinyl)benzoic acid chemical structure, C25H23NO6, CAS 309271-72-5
4-(6,7-Dimethoxy-1-(4-methoxyphenyl)-3-oxo-3,4-dihydro-2(1H)-isoquinolinyl)benzoic acid
CAS 309271-72-5C25H23NO6
Methyl 4-[6,7-dimethoxy-1-(4-methoxyphenyl)-3-oxo-1,4-dihydroisoquinolin-2-yl]benzoate chemical structure, C26H25NO6, CAS 6039-28-7
Methyl 4-[6,7-dimethoxy-1-(4-methoxyphenyl)-3-oxo-1,4-dihydroisoquinolin-2-yl]benzoate
CAS 6039-28-7C26H25NO6
6,7-Diethoxy-1-(4-methoxyphenyl)-2-phenyl-1,4-dihydroisoquinolin-3-one chemical structure, C26H27NO4, CAS 639005-42-8
6,7-Diethoxy-1-(4-methoxyphenyl)-2-phenyl-1,4-dihydroisoquinolin-3-one
CAS 639005-42-8C26H27NO4
4-(1-(3,4-Dimethoxyphenyl)-6,7-diethoxy-3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)benzoic acid chemical structure, C28H29NO7, CAS 639005-56-4
4-(1-(3,4-Dimethoxyphenyl)-6,7-diethoxy-3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)benzoic acid
CAS 639005-56-4C28H29NO7
3(2H)-Isoquinolinone, 1,4-dihydro-1,2-diphenyl- chemical structure, C21H17NO, CAS 59443-66-2
3(2H)-Isoquinolinone, 1,4-dihydro-1,2-diphenyl-
CAS 59443-66-2C21H17NO
1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-nitrophenyl)-1,2-dihydroisoquinolin-3(4H)-one chemical structure, C25H23ClN2O5, CAS 1821463-86-8
1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-nitrophenyl)-1,2-dihydroisoquinolin-3(4H)-one
CAS 1821463-86-8C25H23ClN2O5
(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-nitrophenyl)-1,2-dihydroisoquinolin-3(4H)-one chemical structure, C25H23ClN2O5, CAS 1821463-87-9
(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-nitrophenyl)-1,2-dihydroisoquinolin-3(4H)-one
CAS 1821463-87-9C25H23ClN2O5
N-(4-(1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)-N-methylacetamide chemical structure, C28H29ClN2O4, CAS 2061979-96-0
N-(4-(1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)-N-methylacetamide
CAS 2061979-96-0C28H29ClN2O4
(S)-2-(4-Aminophenyl)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C25H25ClN2O3, CAS 1821463-88-0
(S)-2-(4-Aminophenyl)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-1,4-dihydroisoquinolin-3(2H)-one
CAS 1821463-88-0C25H25ClN2O3