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Murcko scaffold

(3H)Cgs8216 scaffold

35 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
35
With full pages
7
Scaffold SMILES

O=c1c2cnc3ccccc3c2[nH]n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the (3H)Cgs8216 page
Murcko scaffold O=c1c2cnc3ccccc3c2[nH]n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

2,5-Dihydro-2-(4-methoxyphenyl)-3H-pyrazolo(4,3-c)quinolin-3-one chemical structure, C17H13N3O2, CAS 77779-50-1
2,5-Dihydro-2-(4-methoxyphenyl)-3H-pyrazolo(4,3-c)quinolin-3-one
CAS 77779-50-1C17H13N3O2
(3H)Cgs8216 chemical structure, C16H11N3O, CAS 77779-60-3
(3H)Cgs8216
CAS 77779-60-3C16H11N3O
2-(4-Chlorophenyl)-1H-pyrazolo[4,3-c]quinolin-3-one chemical structure, C16H10ClN3O, CAS 77779-36-3
2-(4-Chlorophenyl)-1H-pyrazolo[4,3-c]quinolin-3-one
CAS 77779-36-3C16H10ClN3O
2-(4-Hydroxyphenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one chemical structure, C16H11N3O2, CAS 77779-51-2
2-(4-Hydroxyphenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
CAS 77779-51-2C16H11N3O2
7-Chloro-2-phenyl-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one chemical structure, C16H10ClN3O, CAS 77779-86-3
7-Chloro-2-phenyl-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
CAS 77779-86-3C16H10ClN3O
Benzoic acid, 4-(6-fluoro-3,5-dihydro-3-oxo-2H-pyrazolo[4,3-c]quinolin-2-yl)- chemical structure, C17H10FN3O3, CAS 486449-65-4
Benzoic acid, 4-(6-fluoro-3,5-dihydro-3-oxo-2H-pyrazolo[4,3-c]quinolin-2-yl)-
CAS 486449-65-4C17H10FN3O3
Benzamide, N-[3-(dimethylamino)propyl]-4-(6-fluoro-3,5-dihydro-3-oxo-2H-pyrazolo[4,3-c]quinolin-2-yl)- chemical structure, C22H22FN5O2, CAS 702705-02-0
Benzamide, N-[3-(dimethylamino)propyl]-4-(6-fluoro-3,5-dihydro-3-oxo-2H-pyrazolo[4,3-c]quinolin-2-yl)-
CAS 702705-02-0C22H22FN5O2
6-Methyl-2-phenyl-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one chemical structure, C17H13N3O, CAS 866143-84-2
6-Methyl-2-phenyl-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
CAS 866143-84-2C17H13N3O
8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one chemical structure, C17H13N3O, CAS 77779-90-9
8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one
CAS 77779-90-9C17H13N3O
8-Chloro-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one chemical structure, C16H10ClN3O, CAS 77780-05-3
8-Chloro-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
CAS 77780-05-3C16H10ClN3O
PZ-II-029 chemical structure, C18H15N3O3, CAS 164025-44-9
PZ-II-029
CAS 164025-44-9C18H15N3O3
3H-Pyrazolo[4,3-c]quinolin-3-one, 8-butyl-2,5-dihydro-2-phenyl- chemical structure, C20H19N3O, CAS 148581-62-8
3H-Pyrazolo[4,3-c]quinolin-3-one, 8-butyl-2,5-dihydro-2-phenyl-
CAS 148581-62-8C20H19N3O
8-Fluoro-2-phenyl-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one chemical structure, C16H10FN3O, CAS 77779-98-7
8-Fluoro-2-phenyl-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
CAS 77779-98-7C16H10FN3O
2-(4-Aminophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one chemical structure, C16H12N4O, CAS 77779-53-4
2-(4-Aminophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
CAS 77779-53-4C16H12N4O
4-(3-Oxo-1,3-dihydro-2H-pyrazolo[4,3-c]quinolin-2-yl)benzoic acid chemical structure, C17H11N3O3, CAS 77779-58-9
4-(3-Oxo-1,3-dihydro-2H-pyrazolo[4,3-c]quinolin-2-yl)benzoic acid
CAS 77779-58-9C17H11N3O3
6-Fluoro-2-phenyl-1H-pyrazolo[4,3-c]quinolin-3-one chemical structure, C16H10FN3O, CAS 1015605-39-6
6-Fluoro-2-phenyl-1H-pyrazolo[4,3-c]quinolin-3-one
CAS 1015605-39-6C16H10FN3O
N-Butyl-3-oxo-2-(p-tolyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-8-carboxamide chemical structure, C22H22N4O2, CAS 1251590-95-0
N-Butyl-3-oxo-2-(p-tolyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-8-carboxamide
CAS 1251590-95-0C22H22N4O2
N-(2-Methoxyethyl)-3-oxo-2-(p-tolyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-8-carboxamide chemical structure, C21H20N4O3, CAS 1251634-00-0
N-(2-Methoxyethyl)-3-oxo-2-(p-tolyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-8-carboxamide
CAS 1251634-00-0C21H20N4O3
N-Isopropyl-3-oxo-2-(p-tolyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-8-carboxamide chemical structure, C21H20N4O2, CAS 1251611-56-9
N-Isopropyl-3-oxo-2-(p-tolyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-8-carboxamide
CAS 1251611-56-9C21H20N4O2
N-(3-Methoxypropyl)-2-(4-methylphenyl)-3-oxo-2H,3H,5H-pyrazolo[4,3-c]quinoline-8-carboxamide chemical structure, C22H22N4O3, CAS 1251566-29-6
N-(3-Methoxypropyl)-2-(4-methylphenyl)-3-oxo-2H,3H,5H-pyrazolo[4,3-c]quinoline-8-carboxamide
CAS 1251566-29-6C22H22N4O3
N-(3-Acetylphenyl)-6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide chemical structure, C23H24N4O3, CAS 1251695-20-1
N-(3-Acetylphenyl)-6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide
CAS 1251695-20-1C23H24N4O3
2-(3,4-Dimethylphenyl)-N-(3-ethoxypropyl)-3-oxo-2H,3H,5H-pyrazolo[4,3-c]quinoline-8-carboxamide chemical structure, C24H26N4O3, CAS 1251702-99-4
2-(3,4-Dimethylphenyl)-N-(3-ethoxypropyl)-3-oxo-2H,3H,5H-pyrazolo[4,3-c]quinoline-8-carboxamide
CAS 1251702-99-4C24H26N4O3
N-Butyl-2-(4-chlorophenyl)-3-oxo-2H,3H,5H-pyrazolo[4,3-c]quinoline-8-carboxamide chemical structure, C21H19ClN4O2, CAS 1251616-40-6
N-Butyl-2-(4-chlorophenyl)-3-oxo-2H,3H,5H-pyrazolo[4,3-c]quinoline-8-carboxamide
CAS 1251616-40-6C21H19ClN4O2
2-(4-Chlorophenyl)-N-(2-methoxyethyl)-3-oxo-2H,3H,5H-pyrazolo[4,3-c]quinoline-8-carboxamide chemical structure, C20H17ClN4O3, CAS 1251601-14-5
2-(4-Chlorophenyl)-N-(2-methoxyethyl)-3-oxo-2H,3H,5H-pyrazolo[4,3-c]quinoline-8-carboxamide
CAS 1251601-14-5C20H17ClN4O3