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Murcko scaffold

Ring system with 4 rings and 20 atoms

148 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
148
With full pages
7
Scaffold SMILES

S=c1c2c(sn1-c1ccccc1)CNc1ccccc1-2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=c1c2c(sn1-c1ccccc1)CNc1ccccc1-2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 148 chemicals

2-(3,4-Dimethoxyphenyl)-8-ethoxy-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C22H24N2O3S2, CAS 333340-30-0
2-(3,4-Dimethoxyphenyl)-8-ethoxy-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 333340-30-0C22H24N2O3S2
2-(3,4-Dimethoxyphenyl)-4,4,7-trimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione chemical structure, C21H22N2O2S2, CAS 328069-95-0
2-(3,4-Dimethoxyphenyl)-4,4,7-trimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione
CAS 328069-95-0C21H22N2O2S2
Ethyl 4-(8-methoxy-4,4-dimethyl-1-thioxo-4,5-dihydroisothiazolo[5,4-c]quinolin-2(1H)-yl)benzoate chemical structure, C22H22N2O3S2, CAS 330832-90-1
Ethyl 4-(8-methoxy-4,4-dimethyl-1-thioxo-4,5-dihydroisothiazolo[5,4-c]quinolin-2(1H)-yl)benzoate
CAS 330832-90-1C22H22N2O3S2
2-(3-Fluorophenyl)-4,4,6-trimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione chemical structure, C19H17FN2S2, CAS 305811-80-7
2-(3-Fluorophenyl)-4,4,6-trimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione
CAS 305811-80-7C19H17FN2S2
8-Methoxy-2-(3-methoxyphenyl)-4,4-dimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione chemical structure, C20H20N2O2S2, CAS 327170-69-4
8-Methoxy-2-(3-methoxyphenyl)-4,4-dimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione
CAS 327170-69-4C20H20N2O2S2
8-Methoxy-4,4-dimethyl-2-phenyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C19H18N2OS2, CAS 306737-49-5
8-Methoxy-4,4-dimethyl-2-phenyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 306737-49-5C19H18N2OS2
N-[4-(4,4-Dimethyl-1-sulfanylidene-5H-[1,2]thiazolo[5,4-c]quinolin-2-yl)phenyl]acetamide chemical structure, C20H19N3OS2, CAS 332074-30-3
N-[4-(4,4-Dimethyl-1-sulfanylidene-5H-[1,2]thiazolo[5,4-c]quinolin-2-yl)phenyl]acetamide
CAS 332074-30-3C20H19N3OS2
2-(4-Methoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C19H18N2OS2, CAS 303014-00-8
2-(4-Methoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 303014-00-8C19H18N2OS2
2-(4-Methoxyphenyl)-4,4,8-trimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C20H20N2OS2, CAS 303177-20-0
2-(4-Methoxyphenyl)-4,4,8-trimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 303177-20-0C20H20N2OS2
8-Methoxy-4,4-dimethyl-2-(3-methylphenyl)-4,5-dihydro[1,2]thiazolo[5,4-c]quinoline-1(2H)-thione chemical structure, C20H20N2OS2, CAS 303013-93-6
8-Methoxy-4,4-dimethyl-2-(3-methylphenyl)-4,5-dihydro[1,2]thiazolo[5,4-c]quinoline-1(2H)-thione
CAS 303013-93-6C20H20N2OS2
2-(4-Bromophenyl)-8-methoxy-4,4-dimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione chemical structure, C19H17BrN2OS2, CAS 330440-09-0
2-(4-Bromophenyl)-8-methoxy-4,4-dimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione
CAS 330440-09-0C19H17BrN2OS2
N-[4-(4,4,7-Trimethyl-1-sulfanylidene-5H-[1,2]thiazolo[5,4-c]quinolin-2-yl)phenyl]acetamide chemical structure, C21H21N3OS2, CAS 332074-34-7
N-[4-(4,4,7-Trimethyl-1-sulfanylidene-5H-[1,2]thiazolo[5,4-c]quinolin-2-yl)phenyl]acetamide
CAS 332074-34-7C21H21N3OS2
N-[4-(4,4,8-Trimethyl-1-thioxo-4,5-dihydroisothiazolo[5,4-c]quinolin-2(1H)-yl)phenyl]acetamide chemical structure, C21H21N3OS2, CAS 332074-31-4
N-[4-(4,4,8-Trimethyl-1-thioxo-4,5-dihydroisothiazolo[5,4-c]quinolin-2(1H)-yl)phenyl]acetamide
CAS 332074-31-4C21H21N3OS2
N-[4-(8-Ethoxy-4,4-dimethyl-1-sulfanylidene-5H-[1,2]thiazolo[5,4-c]quinolin-2-yl)phenyl]acetamide chemical structure, C22H23N3O2S2, CAS 332074-33-6
N-[4-(8-Ethoxy-4,4-dimethyl-1-sulfanylidene-5H-[1,2]thiazolo[5,4-c]quinolin-2-yl)phenyl]acetamide
CAS 332074-33-6C22H23N3O2S2
N-[4-(4,4,7,8-Tetramethyl-1-thioxo-4,5-dihydro[1,2]thiazolo[5,4-c]quinolin-2(1H)-yl)phenyl]acetamide chemical structure, C22H23N3OS2, CAS 332074-35-8
N-[4-(4,4,7,8-Tetramethyl-1-thioxo-4,5-dihydro[1,2]thiazolo[5,4-c]quinolin-2(1H)-yl)phenyl]acetamide
CAS 332074-35-8C22H23N3OS2
7-Methoxy-4,4-dimethyl-2-phenyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione chemical structure, C19H18N2OS2, CAS 330180-67-1
7-Methoxy-4,4-dimethyl-2-phenyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione
CAS 330180-67-1C19H18N2OS2
7-Methoxy-4,4-dimethyl-2-(4-methylphenyl)-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione chemical structure, C20H20N2OS2, CAS 350994-90-0
7-Methoxy-4,4-dimethyl-2-(4-methylphenyl)-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione
CAS 350994-90-0C20H20N2OS2
7-Methoxy-2-(4-methoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C20H20N2O2S2, CAS 350994-91-1
7-Methoxy-2-(4-methoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 350994-91-1C20H20N2O2S2
8-Bromo-2-(4-methoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C19H17BrN2OS2, CAS 304013-24-9
8-Bromo-2-(4-methoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 304013-24-9C19H17BrN2OS2
5-Acetyl-4,4-dimethyl-2-(4-methylphenyl)-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione chemical structure, C21H20N2OS2, CAS 327170-79-6
5-Acetyl-4,4-dimethyl-2-(4-methylphenyl)-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione
CAS 327170-79-6C21H20N2OS2
2-(3-Methoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C19H18N2OS2, CAS 303226-82-6
2-(3-Methoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 303226-82-6C19H18N2OS2
8-Methoxy-4,4-dimethyl-2-(2-methylphenyl)-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C20H20N2OS2, CAS 330440-08-9
8-Methoxy-4,4-dimethyl-2-(2-methylphenyl)-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 330440-08-9C20H20N2OS2
2-(3,4-Dimethoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione chemical structure, C20H20N2O2S2, CAS 333340-28-6
2-(3,4-Dimethoxyphenyl)-4,4-dimethyl-5H-[1,2]thiazolo[5,4-c]quinoline-1-thione
CAS 333340-28-6C20H20N2O2S2
2-(3,4-Dimethoxyphenyl)-8-methoxy-4,4-dimethyl-5H-isothiazolo[5,4-c]quinoline-1-thione chemical structure, C21H22N2O3S2, CAS 309265-64-3
2-(3,4-Dimethoxyphenyl)-8-methoxy-4,4-dimethyl-5H-isothiazolo[5,4-c]quinoline-1-thione
CAS 309265-64-3C21H22N2O3S2