Murcko scaffold
Ring system with 4 rings and 24 atoms
58 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 58
- With full pages
- 1
Scaffold SMILES
O=c1c2ccsc2n(Cc2ccccc2)c(=O)n1-c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 58 chemicals
![N,N,5-trimethyl-1-[(3-methylphenyl)methyl]-2,4-dioxo-3-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C25H22F3N3O3S, CAS 865655-95-4](/s/VZYORQCKABCUOL-UHFFFAOYSA-N.svg)
N,N,5-trimethyl-1-[(3-methylphenyl)methyl]-2,4-dioxo-3-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
CAS 865655-95-4C25H22F3N3O3S
![1-[(5-Formyl-2-methoxyphenyl)methyl]-N,N,5-trimethyl-2,4-dioxo-3-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C26H22F3N3O5S, CAS 865656-57-1](/s/VQKQNFOKBQIKNW-UHFFFAOYSA-N.svg)
1-[(5-Formyl-2-methoxyphenyl)methyl]-N,N,5-trimethyl-2,4-dioxo-3-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
CAS 865656-57-1C26H22F3N3O5S
![3-(4-Fluorophenyl)-N,N,5-trimethyl-1-[(3-nitrophenyl)methyl]-2,4-dioxothieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C23H19FN4O5S, CAS 866015-73-8](/s/HHSORJYJWRXYHK-UHFFFAOYSA-N.svg)
3-(4-Fluorophenyl)-N,N,5-trimethyl-1-[(3-nitrophenyl)methyl]-2,4-dioxothieno[2,3-d]pyrimidine-6-carboxamide
CAS 866015-73-8C23H19FN4O5S
![3-(4-Fluorophenyl)-1-[(5-formyl-2-methoxyphenyl)methyl]-N,N,5-trimethyl-2,4-dioxothieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C25H22FN3O5S, CAS 866015-77-2](/s/IDPLEWOVLPWTOK-UHFFFAOYSA-N.svg)
3-(4-Fluorophenyl)-1-[(5-formyl-2-methoxyphenyl)methyl]-N,N,5-trimethyl-2,4-dioxothieno[2,3-d]pyrimidine-6-carboxamide
CAS 866015-77-2C25H22FN3O5S
![N,N-Diethyl-5-methyl-1-[(3-nitrophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C25H24N4O5S, CAS 866015-78-3](/s/CTDJSVAWALBKLW-UHFFFAOYSA-N.svg)
N,N-Diethyl-5-methyl-1-[(3-nitrophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidine-6-carboxamide
CAS 866015-78-3C25H24N4O5S
![1-[(3-Fluorophenyl)methyl]-N,N,5-trimethyl-2,4-dioxo-3-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C24H19F4N3O3S, CAS 866349-13-5](/s/JAEOIJOTAMYIRL-UHFFFAOYSA-N.svg)
1-[(3-Fluorophenyl)methyl]-N,N,5-trimethyl-2,4-dioxo-3-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
CAS 866349-13-5C24H19F4N3O3S
![1-[(2,5-Dimethylphenyl)methyl]-N,N,5-trimethyl-2,4-dioxo-3-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C26H24F3N3O3S, CAS 866349-14-6](/s/ZARBOJJIUKMQSQ-UHFFFAOYSA-N.svg)
1-[(2,5-Dimethylphenyl)methyl]-N,N,5-trimethyl-2,4-dioxo-3-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
CAS 866349-14-6C26H24F3N3O3S
![3-(4-Ethoxyphenyl)-5,6-dimethyl-1-(2-methylbenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C24H24N2O3S, CAS 689752-52-1](/s/UEKFKKRVUSUXKW-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)-5,6-dimethyl-1-(2-methylbenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 689752-52-1C24H24N2O3S
![1-(2-Chloro-6-fluorobenzyl)-3-(4-ethoxyphenyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C23H20ClFN2O3S, CAS 689752-73-6](/s/JXUTVNCVUMSPSB-UHFFFAOYSA-N.svg)
1-(2-Chloro-6-fluorobenzyl)-3-(4-ethoxyphenyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 689752-73-6C23H20ClFN2O3S
![3-(2,4-Dimethoxyphenyl)-1-(4-fluorobenzyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C23H21FN2O4S, CAS 899928-39-3](/s/XGLZZKWMKKTVOY-UHFFFAOYSA-N.svg)
3-(2,4-Dimethoxyphenyl)-1-(4-fluorobenzyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 899928-39-3C23H21FN2O4S
![3-(2,4-Dimethoxyphenyl)-5,6-dimethyl-1-(3-methylbenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C24H24N2O4S, CAS 899928-45-1](/s/MXIIJXUGBVWPJM-UHFFFAOYSA-N.svg)
3-(2,4-Dimethoxyphenyl)-5,6-dimethyl-1-(3-methylbenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 899928-45-1C24H24N2O4S
![3-(4-Fluorophenyl)-5,6-dimethyl-1-(3-nitrobenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C21H16FN3O4S, CAS 689753-23-9](/s/IQLLIFBQVJZTKI-UHFFFAOYSA-N.svg)
3-(4-Fluorophenyl)-5,6-dimethyl-1-(3-nitrobenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 689753-23-9C21H16FN3O4S
![3-(4-Chlorophenyl)-5,6-dimethyl-1-(3-nitrobenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C21H16ClN3O4S, CAS 687580-74-1](/s/LBORQWCRALXSNB-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-5,6-dimethyl-1-(3-nitrobenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 687580-74-1C21H16ClN3O4S
![1-(4-Fluorobenzyl)-3-(4-fluorophenyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C21H16F2N2O2S, CAS 899928-17-7](/s/JTNOPLMJUCHLBX-UHFFFAOYSA-N.svg)
1-(4-Fluorobenzyl)-3-(4-fluorophenyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 899928-17-7C21H16F2N2O2S
![1-Benzyl-5,6-dimethyl-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C21H18N2O2S, CAS 892274-44-1](/s/VOXUOFHZDZDYOM-UHFFFAOYSA-N.svg)
1-Benzyl-5,6-dimethyl-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 892274-44-1C21H18N2O2S
![1-Benzyl-3-(4-ethoxyphenyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C23H22N2O3S, CAS 892272-85-4](/s/SOMYPMDOOMDAAT-UHFFFAOYSA-N.svg)
1-Benzyl-3-(4-ethoxyphenyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 892272-85-4C23H22N2O3S
![1-(3-Fluorobenzyl)-3-(3-methoxyphenyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C22H19FN2O3S, CAS 899928-66-6](/s/MXPVJBULDGDABK-UHFFFAOYSA-N.svg)
1-(3-Fluorobenzyl)-3-(3-methoxyphenyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 899928-66-6C22H19FN2O3S
![5,6-Dimethyl-1-[(4-nitrophenyl)methyl]-3-phenyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione chemical structure, C21H17N3O4S, CAS 689754-88-9](/s/YDJMSRFLGWXQNE-UHFFFAOYSA-N.svg)
5,6-Dimethyl-1-[(4-nitrophenyl)methyl]-3-phenyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione
CAS 689754-88-9C21H17N3O4S
![5,6-Dimethyl-1-[(3-methylphenyl)methyl]-3-phenyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione chemical structure, C22H20N2O2S, CAS 899929-39-6](/s/WBYNURHDUPRNSJ-UHFFFAOYSA-N.svg)
5,6-Dimethyl-1-[(3-methylphenyl)methyl]-3-phenyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione
CAS 899929-39-6C22H20N2O2S
![3-(4-Ethoxyphenyl)-5,6-dimethyl-1-(4-nitrobenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C23H21N3O5S, CAS 689752-89-4](/s/DMURTOXNEIPWNV-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)-5,6-dimethyl-1-(4-nitrobenzyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS 689752-89-4C23H21N3O5S
![3-(3,4-Dichlorophenyl)-N,N-diethyl-1-(2-fluorobenzyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C25H22Cl2FN3O3S, CAS 865654-97-3](/s/HVEWKSBTVHDFEX-UHFFFAOYSA-N.svg)
3-(3,4-Dichlorophenyl)-N,N-diethyl-1-(2-fluorobenzyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide
CAS 865654-97-3C25H22Cl2FN3O3S
![3-(3,4-Dichlorophenyl)-N,N-diethyl-5-methyl-1-(4-methylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C26H25Cl2N3O3S, CAS 865654-98-4](/s/ZMRJWUVTINAGSO-UHFFFAOYSA-N.svg)
3-(3,4-Dichlorophenyl)-N,N-diethyl-5-methyl-1-(4-methylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide
CAS 865654-98-4C26H25Cl2N3O3S
![3-(4-Chlorophenyl)-5,6-dimethyl-1-[(4-methylphenyl)methyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione chemical structure, C22H19ClN2O2S, CAS 687580-77-4](/s/OXVROBDPTWHOBM-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-5,6-dimethyl-1-[(4-methylphenyl)methyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione
CAS 687580-77-4C22H19ClN2O2S
![3-(4-Chlorophenyl)-1-[(4-fluorophenyl)methyl]-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione chemical structure, C21H16ClFN2O2S, CAS 687580-88-7](/s/SQFXPPUYKNLCBM-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-1-[(4-fluorophenyl)methyl]-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione
CAS 687580-88-7C21H16ClFN2O2S
- 1-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-chlorophenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione687580-89-8C21H15Cl2FN2O2S
- 1-[(2-Chlorophenyl)methyl]-3-(3,4-dimethylphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione687581-74-4C23H21ClN2O2S
- 1-[(4-Chlorophenyl)methyl]-3-(3,4-dimethylphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione687581-75-5C23H21ClN2O2S
- 3-(3,4-Dimethylphenyl)-1-[(4-fluorophenyl)methyl]-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione687581-87-9C23H21FN2O2S
- 1-Benzyl-3-(3,4-dimethylphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione687581-93-7C23H22N2O2S
- 6-Acetyl-3-(4-chlorophenyl)-5-methyl-1-[(2-methylphenyl)methyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione687582-13-4C23H19ClN2O3S
- 6-Acetyl-3-(4-chlorophenyl)-1-[(2-fluorophenyl)methyl]-5-methyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione687582-16-7C22H16ClFN2O3S
- 6-Acetyl-3-(4-chlorophenyl)-1-[(3-fluorophenyl)methyl]-5-methyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione687582-17-8C22H16ClFN2O3S
- 1-[(2-Chlorophenyl)methyl]-3-(4-ethoxyphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689752-57-6C23H21ClN2O3S
- 1-[(3-Chlorophenyl)methyl]-3-(4-ethoxyphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689752-67-8C23H21ClN2O3S
- 3-(4-Ethoxyphenyl)-1-[(4-fluorophenyl)methyl]-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione899927-89-0C23H21FN2O3S
- 1-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-ethoxyphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689752-94-1C23H20ClFN2O3S
- 3-(4-Ethoxyphenyl)-5,6-dimethyl-1-[(3-methylphenyl)methyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689753-06-8C24H24N2O3S
- 3-(4-Fluorophenyl)-5,6-dimethyl-1-[(2-methylphenyl)methyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689753-12-6C22H19FN2O2S
- 1-[(3-Chlorophenyl)methyl]-3-(4-fluorophenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689753-28-4C21H16ClFN2O2S
- 1-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689753-40-0C21H15ClF2N2O2S
- 3-(2,4-Dimethoxyphenyl)-5,6-dimethyl-1-[(2-methylphenyl)methyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione899928-21-3C24H24N2O4S
- 1-[(2-Chlorophenyl)methyl]-3-(2,4-dimethoxyphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689753-46-6C23H21ClN2O4S
- 1-[(2-Chloro-6-fluorophenyl)methyl]-3-(2,4-dimethoxyphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689753-61-5C23H20ClFN2O4S
- 3-(3-Methoxyphenyl)-5,6-dimethyl-1-[(2-methylphenyl)methyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione899928-57-5C23H22N2O3S
- 1-[(2-Chlorophenyl)methyl]-3-(3-methoxyphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689754-03-8C22H19ClN2O3S
- 1-[(2-Fluorophenyl)methyl]-3-(3-methoxyphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione899928-63-3C22H19FN2O3S
- 1-[(4-Fluorophenyl)methyl]-3-(3-methoxyphenyl)-5,6-dimethyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione899928-88-2C22H19FN2O3S
- 1-[(4-tert-Butylphenyl)methyl]-5,6-dimethyl-3-phenyl-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione689754-61-8C25H26N2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1ccc(-c2nc(NC3CCCCC3)c3cc[nH]c3n2)cc1](/scaffold/QWRCXRFAIZINSM-UHFFFAOYSA-N/structure.svg)
