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Murcko scaffold

6,7-Dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one scaffold

18 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
18
With full pages
3
Scaffold SMILES

O=C1NCCn2cnnc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6,7-Dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one page
Murcko scaffold O=C1NCCn2cnnc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one chemical structure, C6H5F3N4O, CAS 877402-45-4
3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one
CAS 877402-45-4C6H5F3N4O
tert-Butyl 8-Oxo-3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate chemical structure, C11H13F3N4O3, CAS 877402-44-3
tert-Butyl 8-Oxo-3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
CAS 877402-44-3C11H13F3N4O3
tert-Butyl 3-bromo-8-oxo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate chemical structure, C10H13BrN4O3, CAS 1627748-15-5
tert-Butyl 3-bromo-8-oxo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
CAS 1627748-15-5C10H13BrN4O3
3-Bromo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one chemical structure, C5H5BrN4O, CAS 1627748-16-6
3-Bromo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS 1627748-16-6C5H5BrN4O
6,7-Dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one chemical structure, C5H6N4O, CAS 1935315-39-1
6,7-Dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS 1935315-39-1C5H6N4O
3-(Aminomethyl)-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazin-8-one hydrochloride chemical structure, C6H10ClN5O, CAS 2094616-87-0
3-(Aminomethyl)-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazin-8-one hydrochloride
CAS 2094616-87-0C6H10ClN5O
3-(Aminomethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one chemical structure, C6H9N5O, CAS 2094616-86-9
3-(Aminomethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS 2094616-86-9C6H9N5O
3-[(Methylamino)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride chemical structure, C7H13Cl2N5O, CAS 2094616-91-6
3-[(Methylamino)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride
CAS 2094616-91-6C7H13Cl2N5O
3-[(Methylamino)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one chemical structure, C7H11N5O, CAS 2094616-90-5
3-[(Methylamino)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS 2094616-90-5C7H11N5O
3-(2-Aminoethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride chemical structure, C7H13Cl2N5O, CAS 2094611-77-3
3-(2-Aminoethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride
CAS 2094611-77-3C7H13Cl2N5O
3-(2-Aminoethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one chemical structure, C7H11N5O, CAS 2094611-76-2
3-(2-Aminoethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS 2094611-76-2C7H11N5O
3-(Aminomethyl)-7-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride chemical structure, C7H13Cl2N5O, CAS 2094340-67-5
3-(Aminomethyl)-7-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride
CAS 2094340-67-5C7H13Cl2N5O
3-(Aminomethyl)-7-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one chemical structure, C7H11N5O, CAS 2094340-66-4
3-(Aminomethyl)-7-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS 2094340-66-4C7H11N5O
7-Methyl-3-[(methylamino)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride chemical structure, C8H15Cl2N5O, CAS 2094628-99-4
7-Methyl-3-[(methylamino)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride
CAS 2094628-99-4C8H15Cl2N5O
7-Methyl-3-[(methylamino)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one chemical structure, C8H13N5O, CAS 2094628-98-3
7-Methyl-3-[(methylamino)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS 2094628-98-3C8H13N5O
3-(2-Aminoethyl)-7-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride chemical structure, C8H15Cl2N5O, CAS 2094918-71-3
3-(2-Aminoethyl)-7-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one dihydrochloride
CAS 2094918-71-3C8H15Cl2N5O
3-(2-Aminoethyl)-7-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one chemical structure, C8H13N5O, CAS 2094918-70-2
3-(2-Aminoethyl)-7-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
CAS 2094918-70-2C8H13N5O
N-Methyl-N-[(8-oxo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)methyl]sulfamoyl fluoride chemical structure, C7H10FN5O3S, CAS 2411269-25-3
N-Methyl-N-[(8-oxo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)methyl]sulfamoyl fluoride
CAS 2411269-25-3C7H10FN5O3S