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Murcko scaffold

Ring system with 4 rings and 20 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
8
With full pages
1
Scaffold SMILES

c1ccc(-c2cn3nc(N4CCNCC4)sc3n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cn3nc(N4CCNCC4)sc3n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

4-(2-Piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzonitrile chemical structure, C15H14N6S, CAS 924229-14-1
4-(2-Piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzonitrile
CAS 924229-14-1C15H14N6S
N-(tert-Butyl)-6-(4-methylphenyl)-2-piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazol-5-amine chemical structure, C19H26N6S, CAS 1171889-08-9
N-(tert-Butyl)-6-(4-methylphenyl)-2-piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazol-5-amine
CAS 1171889-08-9C19H26N6S
N-(tert-Butyl)-6-phenyl-2-piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazol-5-amine chemical structure, C18H24N6S, CAS 1172988-91-8
N-(tert-Butyl)-6-phenyl-2-piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazol-5-amine
CAS 1172988-91-8C18H24N6S
N-(tert-Butyl)-6-(3-methylphenyl)-2-piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazol-5-amine chemical structure, C19H26N6S, CAS 1172961-18-0
N-(tert-Butyl)-6-(3-methylphenyl)-2-piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazol-5-amine
CAS 1172961-18-0C19H26N6S
1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]piperazine chemical structure, C14H14FN5S, CAS 1193387-25-5
1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]piperazine
CAS 1193387-25-5C14H14FN5S
1-Piperazinecarboxylic acid, 4-[6-(4-fluorophenyl)imidazo[2,1-b]-1,3,4-thiadiazol-2-yl]-2-methyl-, 1,1-dimethylethyl ester, (2R)- chemical structure, C20H24FN5O2S, CAS 1254381-11-7
1-Piperazinecarboxylic acid, 4-[6-(4-fluorophenyl)imidazo[2,1-b]-1,3,4-thiadiazol-2-yl]-2-methyl-, 1,1-dimethylethyl ester, (2R)-
CAS 1254381-11-7C20H24FN5O2S
1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-4-(prop-2-yn-1-yl)piperazine chemical structure, C17H16FN5S, CAS 1375196-35-2
1-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-4-(prop-2-yn-1-yl)piperazine
CAS 1375196-35-2C17H16FN5S
6-(2-Fluorophenyl)-2-(1-piperazinyl)imidazo[2,1-b][1,3,4]thiadiazol-5-amine chemical structure, C14H15FN6S, CAS 2096986-97-7
6-(2-Fluorophenyl)-2-(1-piperazinyl)imidazo[2,1-b][1,3,4]thiadiazol-5-amine
CAS 2096986-97-7C14H15FN6S