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Murcko scaffold

Ring system with 5 rings and 31 atoms

34 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 31
Chemicals: 34
With full pages: 11

Scaffold SMILES

O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1Cc1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1Cc1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

(5Z)-5-((3-(3-Fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C25H18FN3O3S2, CAS 624724-18-1

(5Z)-5-((3-(3-Fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 624724-18-1C₂₅H₁₈FN₃O₃S₂

(5Z)-5-[[3-(2,5-Dimethylphenyl)-1-phenylpyrazol-4-yl]methylidene]-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C26H21N3O2S2, CAS 381704-54-7

(5Z)-5-[[3-(2,5-Dimethylphenyl)-1-phenylpyrazol-4-yl]methylidene]-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 381704-54-7C₂₆H₂₁N₃O₂S₂

(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C24H16FN3O2S2, CAS 313362-37-7

(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 313362-37-7C₂₄H₁₆FN₃O₂S₂

(5Z)-3-(Furan-2-ylmethyl)-5-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C25H19N3O2S2, CAS 313362-43-5

(5Z)-3-(Furan-2-ylmethyl)-5-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one

CAS 313362-43-5C₂₅H₁₉N₃O₂S₂

(5Z)-3-(2-Furylmethyl)-5-{[3-(4-isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H25N3O3S2, CAS 955878-06-5

(5Z)-3-(2-Furylmethyl)-5-{[3-(4-isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one

CAS 955878-06-5C₂₈H₂₅N₃O₃S₂

(5Z)-3-(2-Furylmethyl)-5-{[3-(2-methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H25N3O3S2, CAS 955867-58-0

(5Z)-3-(2-Furylmethyl)-5-{[3-(2-methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one

CAS 955867-58-0C₂₈H₂₅N₃O₃S₂

(5Z)-3-(2-Furylmethyl)-5-((3-(4-isobutoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H27N3O3S2, CAS 623934-86-1

(5Z)-3-(2-Furylmethyl)-5-((3-(4-isobutoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one

CAS 623934-86-1C₂₉H₂₇N₃O₃S₂

(5Z)-3-(Furan-2-ylmethyl)-5-({3-[2-methyl-4-(propan-2-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H25N3O3S2, CAS 956042-12-9

(5Z)-3-(Furan-2-ylmethyl)-5-({3-[2-methyl-4-(propan-2-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one

CAS 956042-12-9C₂₈H₂₅N₃O₃S₂

(5Z)-3-(Furan-2-ylmethyl)-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H23N3O2S3, CAS 1009433-86-6

(5Z)-3-(Furan-2-ylmethyl)-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one

CAS 1009433-86-6C₂₇H₂₃N₃O₂S₃

(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H22ClN3O3S2, CAS 956041-97-7

(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 956041-97-7C₂₇H₂₂ClN₃O₃S₂

(5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H20ClN3O3S2, CAS 956684-12-1

(5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 956684-12-1C₂₆H₂₀ClN₃O₃S₂

(5Z)-3-(Furan-2-ylmethyl)-5-[[1-phenyl-3-(4-prop-2-enoxyphenyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C27H21N3O3S2, CAS 380876-24-4

(5Z)-3-(Furan-2-ylmethyl)-5-[[1-phenyl-3-(4-prop-2-enoxyphenyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 380876-24-4C₂₇H₂₁N₃O₃S₂

(5Z)-5-{[3-(4-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H21N3O3S2, CAS 1164527-64-3

(5Z)-5-{[3-(4-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1164527-64-3C₂₆H₂₁N₃O₃S₂

(5Z)-3-(Furan-2-ylmethyl)-5-{[3-(4-methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H21N3O3S2, CAS 955877-74-4

(5Z)-3-(Furan-2-ylmethyl)-5-{[3-(4-methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one

CAS 955877-74-4C₂₆H₂₁N₃O₃S₂

(5Z)-5-{[3-(4-Ethoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H23N3O3S2, CAS 955895-82-6

(5Z)-5-{[3-(4-Ethoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955895-82-6C₂₇H₂₃N₃O₃S₂

(5Z)-3-(Furan-2-ylmethyl)-5-{[3-(3-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C25H19N3O3S2, CAS 1009189-98-3

(5Z)-3-(Furan-2-ylmethyl)-5-{[3-(3-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one

CAS 1009189-98-3C₂₅H₁₉N₃O₃S₂

(5Z)-3-(Furan-2-ylmethyl)-5-({3-[2-methyl-4-(prop-2-en-1-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H23N3O3S2, CAS 955875-75-9

(5Z)-3-(Furan-2-ylmethyl)-5-({3-[2-methyl-4-(prop-2-en-1-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one

CAS 955875-75-9C₂₈H₂₃N₃O₃S₂

(5Z)-5-{[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H21N3O3S2, CAS 1009438-40-7

(5Z)-5-{[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1009438-40-7C₂₆H₂₁N₃O₃S₂

(5Z)-3-(Furan-2-ylmethyl)-5-{[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H23N3O3S2, CAS 1009438-61-2

(5Z)-3-(Furan-2-ylmethyl)-5-{[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-2-thioxo-1,3-thiazolidin-4-one

CAS 1009438-61-2C₂₇H₂₃N₃O₃S₂

(5Z)-3-(Furan-2-ylmethyl)-5-({3-[2-methyl-4-(2-methylpropoxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H27N3O3S2, CAS 957047-77-7

(5Z)-3-(Furan-2-ylmethyl)-5-({3-[2-methyl-4-(2-methylpropoxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-thioxo-1,3-thiazolidin-4-one

CAS 957047-77-7C₂₉H₂₇N₃O₃S₂

(5Z)-5-((3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H22FN3O3S2, CAS 623936-25-4

(5Z)-5-((3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623936-25-4C₂₇H₂₂FN₃O₃S₂

(5Z)-3-(2-Furylmethyl)-5-((3-(3-isobutoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H27N3O3S2, CAS 623936-45-8

(5Z)-3-(2-Furylmethyl)-5-((3-(3-isobutoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxo-1,3-thiazolidin-4-one

CAS 623936-45-8C₂₉H₂₇N₃O₃S₂

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C24H17N3O2S2, CAS 624724-49-8

(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-yl)methylene]-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 624724-49-8C₂₄H₁₇N₃O₂S₂

(5Z)-5-{[3-(3-Fluoro-4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C25H18FN3O2S2, CAS 623936-05-0

(5Z)-5-{[3-(3-Fluoro-4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(2-furylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623936-05-0C₂₅H₁₈FN₃O₂S₂