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Murcko scaffold

Ring system with 5 rings and 31 atoms

25 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 31
Chemicals: 25
With full pages: 8

Scaffold SMILES

O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1CC1CCCO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)SC(=S)N1CC1CCCO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

(5Z)-5-{[3-(3-Fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C25H22FN3O3S2, CAS 624724-61-4

(5Z)-5-{[3-(3-Fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 624724-61-4C₂₅H₂₂FN₃O₃S₂

(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C24H20FN3O2S2, CAS 313362-45-7

(5Z)-5-{[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 313362-45-7C₂₄H₂₀FN₃O₂S₂

(5Z)-5-[[3-(2,5-Dimethylphenyl)-1-phenylpyrazol-4-yl]methylidene]-3-(oxolan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C26H25N3O2S2, CAS 378219-19-3

(5Z)-5-[[3-(2,5-Dimethylphenyl)-1-phenylpyrazol-4-yl]methylidene]-3-(oxolan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 378219-19-3C₂₆H₂₅N₃O₂S₂

(5Z)-5-{[3-(4-Ethoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H27N3O3S2, CAS 955867-52-4

(5Z)-5-{[3-(4-Ethoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955867-52-4C₂₇H₂₇N₃O₃S₂

(5Z)-5-((3-(3-Isobutoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methyle NE)-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3O3S2, CAS 623936-41-4

(5Z)-5-((3-(3-Isobutoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methyle NE)-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623936-41-4C₂₉H₃₁N₃O₃S₂

(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C24H20ClN3O2S2, CAS 623940-46-5

(5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623940-46-5C₂₄H₂₀ClN₃O₂S₂

(5Z)-5-((1,3-Diphenyl-1H-pyrazol-4-yl)methylene)-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C24H21N3O2S2, CAS 623940-40-9

(5Z)-5-((1,3-Diphenyl-1H-pyrazol-4-yl)methylene)-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623940-40-9C₂₄H₂₁N₃O₂S₂

(5Z)-5-{[3-(2-Methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H29N3O3S2, CAS 955867-40-0

(5Z)-5-{[3-(2-Methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955867-40-0C₂₈H₂₉N₃O₃S₂

(5Z)-5-{[3-(3-Fluoro-4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C25H22FN3O2S2, CAS 623936-03-8

(5Z)-5-{[3-(3-Fluoro-4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623936-03-8C₂₅H₂₂FN₃O₂S₂

(5Z)-5-({3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H25N3O2S3, CAS 1008879-35-3

(5Z)-5-({3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1008879-35-3C₂₆H₂₅N₃O₂S₃

(5Z)-5-{[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H25N3O3S2, CAS 1009189-71-2

(5Z)-5-{[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1009189-71-2C₂₆H₂₅N₃O₃S₂

(5Z)-5-{[3-(4-Butoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3O3S2, CAS 955866-05-4

(5Z)-5-{[3-(4-Butoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955866-05-4C₂₉H₃₁N₃O₃S₂

(5Z)-5-{[3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H26FN3O3S2, CAS 623936-29-8

(5Z)-5-{[3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623936-29-8C₂₇H₂₆FN₃O₃S₂

(5Z)-5-{[3-(4-Methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H25N3O3S2, CAS 955896-74-9

(5Z)-5-{[3-(4-Methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955896-74-9C₂₆H₂₅N₃O₃S₂

(5Z)-5-{[1-Phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H27N3O3S2, CAS 1009436-47-8

(5Z)-5-{[1-Phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1009436-47-8C₂₇H₂₇N₃O₃S₂

(5Z)-5-{[3-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H25N3O4S2, CAS 623935-74-0

(5Z)-5-{[3-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623935-74-0C₂₆H₂₅N₃O₄S₂

(5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C26H24ClN3O3S2, CAS 956377-15-4

(5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 956377-15-4C₂₆H₂₄ClN₃O₃S₂

(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H29N3O2S3, CAS 1008879-66-0

(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1008879-66-0C₂₈H₂₉N₃O₂S₃

(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H26ClN3O3S2, CAS 957034-06-9

(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 957034-06-9C₂₇H₂₆ClN₃O₃S₂

(5Z)-5-({1-Phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C27H27N3O2S3, CAS 1009434-65-4

(5Z)-5-({1-Phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 1009434-65-4C₂₇H₂₇N₃O₂S₃

(5Z)-5-{[3-(4-Isobutoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methyle NE}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3O3S2, CAS 623934-89-4

(5Z)-5-{[3-(4-Isobutoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methyle NE}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 623934-89-4C₂₉H₃₁N₃O₃S₂

(5Z)-5-({3-[2-Methyl-4-(prop-2-en-1-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H27N3O3S2, CAS 955867-17-1

(5Z)-5-({3-[2-Methyl-4-(prop-2-en-1-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 955867-17-1C₂₈H₂₇N₃O₃S₂

(5Z)-5-{[3-(4-Isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C28H29N3O3S2, CAS 956212-09-2

(5Z)-5-{[3-(4-Isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 956212-09-2C₂₈H₂₉N₃O₃S₂

(5Z)-5-({3-[2-Methyl-4-(2-methylpropoxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C29H31N3O3S2, CAS 956204-98-1

(5Z)-5-({3-[2-Methyl-4-(2-methylpropoxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 956204-98-1C₂₉H₃₁N₃O₃S₂

(5Z)-5-({3-[2-Methyl-4-(propan-2-yloxy)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
956236-20-7C₂₈H₂₉N₃O₃S₂