Murcko scaffold
Ring system with 4 rings and 20 atoms
15 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 20
- Chemicals
- 15
- With full pages
- 3
Scaffold SMILES
O=C1Nc2ccccc2C12C=COc1c2occc1=O
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 15 of 15 chemicals
![2'-Amino-6'-(hydroxymethyl)-1-methyl-2,8'-dioxospiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile chemical structure, C18H13N3O5, CAS 674805-66-4](/s/LLPFFRBUBVWHGI-UHFFFAOYSA-N.svg)
2'-Amino-6'-(hydroxymethyl)-1-methyl-2,8'-dioxospiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile
CAS 674805-66-4C18H13N3O5
![2'-Amino-5-fluoro-6'-(hydroxymethyl)-2,8'-dioxospiro[1H-indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile chemical structure, C17H10FN3O5, CAS 797028-40-1](/s/BQMQEFQNLLWPJT-UHFFFAOYSA-N.svg)
2'-Amino-5-fluoro-6'-(hydroxymethyl)-2,8'-dioxospiro[1H-indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile
CAS 797028-40-1C17H10FN3O5
![2'-Amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile chemical structure, C17H11N3O5, CAS 625376-07-0](/s/QIDLYGWVVFGDRV-UHFFFAOYSA-N.svg)
2'-Amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile
CAS 625376-07-0C17H11N3O5
![2'-Amino-6'-(hydroxymethyl)-5-nitro-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile chemical structure, C17H10N4O7, CAS 625376-14-9](/s/DMLYUPPXVIRORR-UHFFFAOYSA-N.svg)
2'-Amino-6'-(hydroxymethyl)-5-nitro-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile
CAS 625376-14-9C17H10N4O7
![2'-Amino-1-ethyl-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile chemical structure, C19H15N3O5, CAS 626228-61-3](/s/ZJEWRSOGMRXSKI-UHFFFAOYSA-N.svg)
2'-Amino-1-ethyl-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile
CAS 626228-61-3C19H15N3O5
![2'-Amino-5-bromo-6'-(hydroxymethyl)-1-methyl-2,8'-dioxospiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile chemical structure, C18H12BrN3O5, CAS 674806-57-6](/s/YQJRUZKPRIDQAY-UHFFFAOYSA-N.svg)
2'-Amino-5-bromo-6'-(hydroxymethyl)-1-methyl-2,8'-dioxospiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile
CAS 674806-57-6C18H12BrN3O5
![1-Acetyl-2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile chemical structure, C19H13N3O6, CAS 939893-52-4](/s/FNFCFMCLZSQLKS-UHFFFAOYSA-N.svg)
1-Acetyl-2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carbonitrile
CAS 939893-52-4C19H13N3O6
![Methyl 2'-amino-1-ethyl-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate chemical structure, C20H18N2O7, CAS 884214-48-6](/s/MYMKPTFMECXNRN-UHFFFAOYSA-N.svg)
Methyl 2'-amino-1-ethyl-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate
CAS 884214-48-6C20H18N2O7
![Methyl 1-allyl-2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate chemical structure, C21H18N2O7, CAS 884214-79-3](/s/DOQQYIYCMMZDHV-UHFFFAOYSA-N.svg)
Methyl 1-allyl-2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate
CAS 884214-79-3C21H18N2O7
![Ethyl 1-allyl-2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate chemical structure, C22H20N2O7, CAS 884214-84-0](/s/HFYPAEFERNUPJG-UHFFFAOYSA-N.svg)
Ethyl 1-allyl-2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate
CAS 884214-84-0C22H20N2O7
![Methyl 2'-amino-1-(carbamoylmethyl)-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate chemical structure, C20H17N3O8, CAS 884214-89-5](/s/ZBINVJIYRANYAM-UHFFFAOYSA-N.svg)
Methyl 2'-amino-1-(carbamoylmethyl)-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate
CAS 884214-89-5C20H17N3O8
![Ethyl 2'-amino-1-(carbamoylmethyl)-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate chemical structure, C21H19N3O8, CAS 884214-94-2](/s/NHAUEYYHXBIUBE-UHFFFAOYSA-N.svg)
Ethyl 2'-amino-1-(carbamoylmethyl)-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate
CAS 884214-94-2C21H19N3O8
![2-[2'-Amino-3'-cyano-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-1-yl]acetamide chemical structure, C19H14N4O6, CAS 884215-00-3](/s/LDOFNDAXFFIZEH-UHFFFAOYSA-N.svg)
2-[2'-Amino-3'-cyano-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-1-yl]acetamide
CAS 884215-00-3C19H14N4O6
![Ethyl 2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate chemical structure, C19H16N2O7, CAS 884213-99-4](/s/JNAOMCNYZPKFLQ-UHFFFAOYSA-N.svg)
Ethyl 2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate
CAS 884213-99-4C19H16N2O7
![Methyl 2'-amino-6'-(hydroxymethyl)-1-(2-methoxy-2-oxoethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate chemical structure, C21H18N2O9, CAS 884215-06-9](/s/OHHBRSKTVJHLSI-UHFFFAOYSA-N.svg)
Methyl 2'-amino-6'-(hydroxymethyl)-1-(2-methoxy-2-oxoethyl)-2,8'-dioxo-1,2-dihydro-8'H-spiro[indole-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate
CAS 884215-06-9C21H18N2O9
Related scaffolds
Same ring framework with different atoms or bond orders
