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Murcko scaffold

Ring system with 4 rings and 20 atoms

28 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
28
With full pages
6
Scaffold SMILES

O=C1CCCC2=C1C1(C=CO2)C(=O)Nc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCCC2=C1C1(C=CO2)C(=O)Nc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

2-Amino-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile chemical structure, C17H13N3O3, CAS 74647-54-4
2-Amino-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile
CAS 74647-54-4C17H13N3O3
2-Amino-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile chemical structure, C19H17N3O3, CAS 119771-51-6
2-Amino-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile
CAS 119771-51-6C19H17N3O3
2-Amino-5'-bromo-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile chemical structure, C19H16BrN3O3, CAS 330158-80-0
2-Amino-5'-bromo-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile
CAS 330158-80-0C19H16BrN3O3
Ethyl 2-amino-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carboxylate chemical structure, C21H22N2O5, CAS 336180-95-1
Ethyl 2-amino-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carboxylate
CAS 336180-95-1C21H22N2O5
2-Amino-5'-nitro-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile chemical structure, C17H12N4O5, CAS 300733-25-9
2-Amino-5'-nitro-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile
CAS 300733-25-9C17H12N4O5
Propan-2-yl 2-amino-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carboxylate chemical structure, C22H24N2O5, CAS 296879-51-1
Propan-2-yl 2-amino-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carboxylate
CAS 296879-51-1C22H24N2O5
Ethyl 2-amino-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carboxylate chemical structure, C19H18N2O5, CAS 210232-93-2
Ethyl 2-amino-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carboxylate
CAS 210232-93-2C19H18N2O5
2-Amino-1'-ethyl-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carbonitrile chemical structure, C21H21N3O3, CAS 665000-05-5
2-Amino-1'-ethyl-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carbonitrile
CAS 665000-05-5C21H21N3O3
2-Amino-1'-ethyl-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile chemical structure, C19H17N3O3, CAS 665000-06-6
2-Amino-1'-ethyl-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile
CAS 665000-06-6C19H17N3O3
2-Amino-7,7-dimethyl-5'-nitro-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile chemical structure, C19H16N4O5, CAS 313381-52-1
2-Amino-7,7-dimethyl-5'-nitro-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile
CAS 313381-52-1C19H16N4O5
2-Amino-1',7,7-trimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carbonitrile chemical structure, C20H19N3O3, CAS 119787-57-4
2-Amino-1',7,7-trimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carbonitrile
CAS 119787-57-4C20H19N3O3
Ethyl 2-(2-amino-3-cyano-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-1'-yl)acetate chemical structure, C23H23N3O5, CAS 445222-94-6
Ethyl 2-(2-amino-3-cyano-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-1'-yl)acetate
CAS 445222-94-6C23H23N3O5
Ethyl 2-amino-1',7,7-trimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carboxylate chemical structure, C22H24N2O5, CAS 445222-66-2
Ethyl 2-amino-1',7,7-trimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carboxylate
CAS 445222-66-2C22H24N2O5
Methyl 2-amino-1'-methyl-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carboxylate chemical structure, C19H18N2O5, CAS 445222-72-0
Methyl 2-amino-1'-methyl-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carboxylate
CAS 445222-72-0C19H18N2O5
Methyl 2-amino-1'-(2-methoxy-2-oxoethyl)-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carboxylate chemical structure, C23H24N2O7, CAS 445222-75-3
Methyl 2-amino-1'-(2-methoxy-2-oxoethyl)-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carboxylate
CAS 445222-75-3C23H24N2O7
Methyl 2-(2-amino-3-cyano-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-1'-yl)acetate chemical structure, C20H17N3O5, CAS 445222-69-5
Methyl 2-(2-amino-3-cyano-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-1'-yl)acetate
CAS 445222-69-5C20H17N3O5
Ethyl 2-(2-amino-3-cyano-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-1'-yl)acetate chemical structure, C21H19N3O5, CAS 445222-95-7
Ethyl 2-(2-amino-3-cyano-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-1'-yl)acetate
CAS 445222-95-7C21H19N3O5
tert-Butyl 2'-amino-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,4'-6,8-dihydrochromene]-3'-carboxylate chemical structure, C23H26N2O5, CAS 312608-97-2
tert-Butyl 2'-amino-7',7'-dimethyl-2,5'-dioxospiro[1H-indole-3,4'-6,8-dihydrochromene]-3'-carboxylate
CAS 312608-97-2C23H26N2O5
Ethyl 2-amino-2',5-dioxo-1'-prop-2-enylspiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carboxylate chemical structure, C22H22N2O5, CAS 445222-60-6
Ethyl 2-amino-2',5-dioxo-1'-prop-2-enylspiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carboxylate
CAS 445222-60-6C22H22N2O5
2-Amino-1',7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile chemical structure, C19H17N3O3, CAS 674805-69-7
2-Amino-1',7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile
CAS 674805-69-7C19H17N3O3
Methyl 2-(2-amino-3-cyano-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-1'-yl)acetate chemical structure, C22H21N3O5, CAS 445222-68-4
Methyl 2-(2-amino-3-cyano-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-1'-yl)acetate
CAS 445222-68-4C22H21N3O5
2-Amino-2',5-dioxo-1'-prop-2-enylspiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile chemical structure, C20H17N3O3, CAS 352663-40-2
2-Amino-2',5-dioxo-1'-prop-2-enylspiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile
CAS 352663-40-2C20H17N3O3
2-Amino-1'-(hydroxymethyl)-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carbonitrile chemical structure, C20H19N3O4, CAS 352663-15-1
2-Amino-1'-(hydroxymethyl)-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carbonitrile
CAS 352663-15-1C20H19N3O4
2-Amino-7,7-dimethyl-2',5-dioxo-1'-prop-2-enylspiro[6,8-dihydrochromene-4,3'-indole]-3-carbonitrile chemical structure, C22H21N3O3, CAS 352663-37-7
2-Amino-7,7-dimethyl-2',5-dioxo-1'-prop-2-enylspiro[6,8-dihydrochromene-4,3'-indole]-3-carbonitrile
CAS 352663-37-7C22H21N3O3