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Murcko scaffold

Ring system with 4 rings and 26 atoms

38 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
38
With full pages
6
Scaffold SMILES

O=S(=O)(c1ccccc1)c1nc(-c2ccccc2)oc1N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(c1ccccc1)c1nc(-c2ccccc2)oc1N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

4-((4-Chlorophenyl)sulfonyl)-5-(4-methylpiperazin-1-yl)-2-(o-tolyl)oxazole chemical structure, C21H22ClN3O3S, CAS 823828-56-4
4-((4-Chlorophenyl)sulfonyl)-5-(4-methylpiperazin-1-yl)-2-(o-tolyl)oxazole
CAS 823828-56-4C21H22ClN3O3S
1-[2-(2-Chlorophenyl)-4-(phenylsulfonyl)-1,3-oxazol-5-yl]-4-methylpiperazine chemical structure, C20H20ClN3O3S, CAS 380318-88-7
1-[2-(2-Chlorophenyl)-4-(phenylsulfonyl)-1,3-oxazol-5-yl]-4-methylpiperazine
CAS 380318-88-7C20H20ClN3O3S
4-((4-Chlorophenyl)sulfonyl)-2-(2-fluorophenyl)-5-(4-methylpiperazin-1-yl)oxazole chemical structure, C20H19ClFN3O3S, CAS 823829-91-0
4-((4-Chlorophenyl)sulfonyl)-2-(2-fluorophenyl)-5-(4-methylpiperazin-1-yl)oxazole
CAS 823829-91-0C20H19ClFN3O3S
1-Ethyl-4-[4-(4-methylbenzenesulfonyl)-2-phenyl-1,3-oxazol-5-yl]piperazine chemical structure, C22H25N3O3S, CAS 377766-06-8
1-Ethyl-4-[4-(4-methylbenzenesulfonyl)-2-phenyl-1,3-oxazol-5-yl]piperazine
CAS 377766-06-8C22H25N3O3S
4-(Benzenesulfonyl)-5-(4-methylpiperazin-1-yl)-2-phenyl-1,3-oxazole chemical structure, C20H21N3O3S, CAS 380575-58-6
4-(Benzenesulfonyl)-5-(4-methylpiperazin-1-yl)-2-phenyl-1,3-oxazole
CAS 380575-58-6C20H21N3O3S
2-(2-Chlorophenyl)-4-(4-methylphenyl)sulfonyl-5-(4-methylpiperazin-1-yl)-1,3-oxazole chemical structure, C21H22ClN3O3S, CAS 380190-49-8
2-(2-Chlorophenyl)-4-(4-methylphenyl)sulfonyl-5-(4-methylpiperazin-1-yl)-1,3-oxazole
CAS 380190-49-8C21H22ClN3O3S
1-{4-[(4-Fluorophenyl)sulfonyl]-2-phenyl-1,3-oxazol-5-yl}-4-methylpiperazine chemical structure, C20H20FN3O3S, CAS 823828-55-3
1-{4-[(4-Fluorophenyl)sulfonyl]-2-phenyl-1,3-oxazol-5-yl}-4-methylpiperazine
CAS 823828-55-3C20H20FN3O3S
1-[2-(4-Chlorophenyl)-4-(4-methylbenzenesulfonyl)-1,3-oxazol-5-yl]-4-methylpiperazine chemical structure, C21H22ClN3O3S, CAS 630084-57-0
1-[2-(4-Chlorophenyl)-4-(4-methylbenzenesulfonyl)-1,3-oxazol-5-yl]-4-methylpiperazine
CAS 630084-57-0C21H22ClN3O3S
2-(4-Methoxyphenyl)-5-(4-methylpiperazin-1-yl)-4-(phenylsulfonyl)oxazole chemical structure, C21H23N3O4S, CAS 855715-00-3
2-(4-Methoxyphenyl)-5-(4-methylpiperazin-1-yl)-4-(phenylsulfonyl)oxazole
CAS 855715-00-3C21H23N3O4S
5-(4-Methylpiperazin-1-yl)-4-(phenylsulfonyl)-2-(p-tolyl)oxazole chemical structure, C21H23N3O3S, CAS 862741-04-6
5-(4-Methylpiperazin-1-yl)-4-(phenylsulfonyl)-2-(p-tolyl)oxazole
CAS 862741-04-6C21H23N3O3S
4-((4-Chlorophenyl)sulfonyl)-5-(4-methylpiperazin-1-yl)-2-(m-tolyl)oxazole chemical structure, C21H22ClN3O3S, CAS 862741-19-3
4-((4-Chlorophenyl)sulfonyl)-5-(4-methylpiperazin-1-yl)-2-(m-tolyl)oxazole
CAS 862741-19-3C21H22ClN3O3S
5-(4-Ethylpiperazin-1-yl)-4-(phenylsulfonyl)-2-(p-tolyl)oxazole chemical structure, C22H25N3O3S, CAS 862758-85-8
5-(4-Ethylpiperazin-1-yl)-4-(phenylsulfonyl)-2-(p-tolyl)oxazole
CAS 862758-85-8C22H25N3O3S
4-((4-Chlorophenyl)sulfonyl)-5-(4-ethylpiperazin-1-yl)-2-(p-tolyl)oxazole chemical structure, C22H24ClN3O3S, CAS 862758-86-9
4-((4-Chlorophenyl)sulfonyl)-5-(4-ethylpiperazin-1-yl)-2-(p-tolyl)oxazole
CAS 862758-86-9C22H24ClN3O3S
5-(4-Ethylpiperazin-1-yl)-4-((4-fluorophenyl)sulfonyl)-2-(m-tolyl)oxazole chemical structure, C22H24FN3O3S, CAS 862758-97-2
5-(4-Ethylpiperazin-1-yl)-4-((4-fluorophenyl)sulfonyl)-2-(m-tolyl)oxazole
CAS 862758-97-2C22H24FN3O3S
2-(2-Fluorophenyl)-5-(4-methylpiperazin-1-yl)-4-(phenylsulfonyl)oxazole chemical structure, C20H20FN3O3S, CAS 862797-70-4
2-(2-Fluorophenyl)-5-(4-methylpiperazin-1-yl)-4-(phenylsulfonyl)oxazole
CAS 862797-70-4C20H20FN3O3S
2-(2-Fluorophenyl)-4-((4-fluorophenyl)sulfonyl)-5-(4-methylpiperazin-1-yl)oxazole chemical structure, C20H19F2N3O3S, CAS 862798-67-2
2-(2-Fluorophenyl)-4-((4-fluorophenyl)sulfonyl)-5-(4-methylpiperazin-1-yl)oxazole
CAS 862798-67-2C20H19F2N3O3S
4-((4-Fluorophenyl)sulfonyl)-5-(4-methylpiperazin-1-yl)-2-(p-tolyl)oxazole chemical structure, C21H22FN3O3S, CAS 862741-02-4
4-((4-Fluorophenyl)sulfonyl)-5-(4-methylpiperazin-1-yl)-2-(p-tolyl)oxazole
CAS 862741-02-4C21H22FN3O3S
5-(4-Methylpiperazin-1-yl)-2-(p-tolyl)-4-tosyloxazole chemical structure, C22H25N3O3S, CAS 862741-03-5
5-(4-Methylpiperazin-1-yl)-2-(p-tolyl)-4-tosyloxazole
CAS 862741-03-5C22H25N3O3S
2-(4-Fluorophenyl)-5-(4-methylpiperazin-1-yl)-4-(phenylsulfonyl)oxazole chemical structure, C20H20FN3O3S, CAS 862741-09-1
2-(4-Fluorophenyl)-5-(4-methylpiperazin-1-yl)-4-(phenylsulfonyl)oxazole
CAS 862741-09-1C20H20FN3O3S
5-(4-Methylpiperazin-1-yl)-2-(o-tolyl)-4-tosyloxazole chemical structure, C22H25N3O3S, CAS 862741-12-6
5-(4-Methylpiperazin-1-yl)-2-(o-tolyl)-4-tosyloxazole
CAS 862741-12-6C22H25N3O3S
5-(4-Methylpiperazin-1-yl)-4-(phenylsulfonyl)-2-(o-tolyl)oxazole chemical structure, C21H23N3O3S, CAS 862741-13-7
5-(4-Methylpiperazin-1-yl)-4-(phenylsulfonyl)-2-(o-tolyl)oxazole
CAS 862741-13-7C21H23N3O3S
5-(4-Ethylpiperazin-1-yl)-2-(p-tolyl)-4-tosyloxazole chemical structure, C23H27N3O3S, CAS 862758-84-7
5-(4-Ethylpiperazin-1-yl)-2-(p-tolyl)-4-tosyloxazole
CAS 862758-84-7C23H27N3O3S
5-(4-Ethylpiperazin-1-yl)-2-(o-tolyl)-4-tosyloxazole chemical structure, C23H27N3O3S, CAS 862758-93-8
5-(4-Ethylpiperazin-1-yl)-2-(o-tolyl)-4-tosyloxazole
CAS 862758-93-8C23H27N3O3S
4-((4-Chlorophenyl)sulfonyl)-5-(4-ethylpiperazin-1-yl)-2-(o-tolyl)oxazole chemical structure, C22H24ClN3O3S, CAS 862758-94-9
4-((4-Chlorophenyl)sulfonyl)-5-(4-ethylpiperazin-1-yl)-2-(o-tolyl)oxazole
CAS 862758-94-9C22H24ClN3O3S