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Murcko scaffold

Ring system with 3 rings and 26 atoms

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
20
With full pages
8
Scaffold SMILES

O=C(CCN1CCN(CC=Cc2ccccc2)CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCN1CCN(CC=Cc2ccccc2)CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

N-(3,4-Difluorophenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}propanamide chemical structure, C22H25F2N3O, CAS 428502-58-3
N-(3,4-Difluorophenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}propanamide
CAS 428502-58-3C22H25F2N3O
N-(3-Methylphenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}propanamide chemical structure, C23H29N3O, CAS 1049977-11-8
N-(3-Methylphenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}propanamide
CAS 1049977-11-8C23H29N3O
N-(2,5-Dimethoxyphenyl)-3-{4-[(2E)-3-phenyl-2-propenyl]-1-piperazinyl}propanamide chemical structure, C24H31N3O3, CAS 1049979-46-5
N-(2,5-Dimethoxyphenyl)-3-{4-[(2E)-3-phenyl-2-propenyl]-1-piperazinyl}propanamide
CAS 1049979-46-5C24H31N3O3
N-(4-Methylphenyl)-3-{4-[(2E)-3-phenyl-2-propenyl]-1-piperazinyl}propanamide chemical structure, C23H29N3O, CAS 1053056-65-7
N-(4-Methylphenyl)-3-{4-[(2E)-3-phenyl-2-propenyl]-1-piperazinyl}propanamide
CAS 1053056-65-7C23H29N3O
N-(2-Methylphenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}propanamide chemical structure, C23H29N3O, CAS 1164496-89-2
N-(2-Methylphenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}propanamide
CAS 1164496-89-2C23H29N3O
N-(2-Fluorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C22H26FN3O, CAS 1164464-82-7
N-(2-Fluorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 1164464-82-7C22H26FN3O
N-(3-Chlorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C22H26ClN3O, CAS 428828-63-1
N-(3-Chlorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 428828-63-1C22H26ClN3O
N-(3-Fluorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C22H26FN3O, CAS 428838-51-1
N-(3-Fluorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 428838-51-1C22H26FN3O
N-(4-Bromophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C22H26BrN3O, CAS 428842-28-8
N-(4-Bromophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 428842-28-8C22H26BrN3O
N-(4-Chlorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C22H26ClN3O, CAS 1164503-60-9
N-(4-Chlorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 1164503-60-9C22H26ClN3O
N-(4-Bromo-3-methylphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C23H28BrN3O, CAS 1049976-98-8
N-(4-Bromo-3-methylphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 1049976-98-8C23H28BrN3O
N-(4-Fluorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C22H26FN3O, CAS 428850-70-8
N-(4-Fluorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 428850-70-8C22H26FN3O
N-(2-Chlorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C22H26ClN3O, CAS 1049979-49-8
N-(2-Chlorophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 1049979-49-8C22H26ClN3O
N-(3-Chloro-2-methylphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C23H28ClN3O, CAS 428823-03-4
N-(3-Chloro-2-methylphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 428823-03-4C23H28ClN3O
N-(2,4-Dimethoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C24H31N3O3, CAS 428826-72-6
N-(2,4-Dimethoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 428826-72-6C24H31N3O3
N-(3,5-Dimethoxy-phenyl)-3-[4-(3-phenyl-allyl)-piperazin-1-yl]-propionamide chemical structure, C24H31N3O3, CAS 428830-24-4
N-(3,5-Dimethoxy-phenyl)-3-[4-(3-phenyl-allyl)-piperazin-1-yl]-propionamide
CAS 428830-24-4C24H31N3O3
N-(2-Methoxy-5-nitrophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C23H28N4O4, CAS 428841-44-5
N-(2-Methoxy-5-nitrophenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 428841-44-5C23H28N4O4
N-(4-Methoxy-phenyl)-3-[4-(3-phenyl-allyl)-piperazin-1-yl]-propionamide chemical structure, C23H29N3O2, CAS 428847-98-7
N-(4-Methoxy-phenyl)-3-[4-(3-phenyl-allyl)-piperazin-1-yl]-propionamide
CAS 428847-98-7C23H29N3O2
N-(3-Methoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C23H29N3O2, CAS 428838-57-7
N-(3-Methoxyphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 428838-57-7C23H29N3O2
N-(2-Methoxy-5-methylphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide chemical structure, C24H31N3O2, CAS 519004-83-2
N-(2-Methoxy-5-methylphenyl)-3-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]propanamide
CAS 519004-83-2C24H31N3O2