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Murcko scaffold

Ring system with 4 rings and 29 atoms

10 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 29
Chemicals: 10
With full pages: 1

Scaffold SMILES

O=S(=O)(Nc1nc(-c2ccncc2)ncc1Oc1ccccc1)c1ccccn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=S(=O)(Nc1nc(-c2ccncc2)ncc1Oc1ccccc1)c1ccccn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

N-(2-(2-(Hydroxymethyl)pyridin-4-yl)-6-methoxy-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide chemical structure, C24H23N5O6S, CAS 285134-89-6

N-(2-(2-(Hydroxymethyl)pyridin-4-yl)-6-methoxy-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide

CAS 285134-89-6C₂₄H₂₃N₅O₆S

Avosentan chemical structure, C23H21N5O5S, CAS 290815-26-8

CAS 290815-26-8C₂₃H₂₁N₅O₅S

N-(6-Chloro-2-(2-cyanopyridin-4-yl)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide chemical structure, C23H17ClN6O4S, CAS 257876-24-7

N-(6-Chloro-2-(2-cyanopyridin-4-yl)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide

CAS 257876-24-7C₂₃H₁₇ClN₆O₄S

5-Methyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridinesulfonamide chemical structure, C22H18ClN5O4S, CAS 290815-30-4

5-Methyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridinesulfonamide

CAS 290815-30-4C₂₂H₁₈ClN₅O₄S

N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-(1-methylethyl)-2-pyridinesulfonamide chemical structure, C25H25N5O5S, CAS 290815-27-9

N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-(1-methylethyl)-2-pyridinesulfonamide

CAS 290815-27-9C₂₅H₂₅N₅O₅S

5-Isopropyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridine sulfonamide chemical structure, C24H22ClN5O4S, CAS 329923-33-3

5-Isopropyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridine sulfonamide

CAS 329923-33-3C₂₄H₂₂ClN₅O₄S

Avosentan-d3 chemical structure, C23H21N5O5S, CAS 1206674-82-9

CAS 1206674-82-9C₂₃H₂₁N₅O₅S

5-Isopropyl-N-(6-methoxy-5-(2-methoxyphenoxy)-2-(2-methoxypyridin-4-yl)pyrimidin-4-yl)pyridine-2-sulfonamide chemical structure, C26H27N5O6S, CAS 285135-18-4

5-Isopropyl-N-(6-methoxy-5-(2-methoxyphenoxy)-2-(2-methoxypyridin-4-yl)pyrimidin-4-yl)pyridine-2-sulfonamide

CAS 285135-18-4C₂₆H₂₇N₅O₆S

N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(2-methoxypyridin-4-yl)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide chemical structure, C24H23N5O6S, CAS 285134-97-6

N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(2-methoxypyridin-4-yl)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide

CAS 285134-97-6C₂₄H₂₃N₅O₆S

N-(6-Chloro-2-(2-cyanopyridin-4-yl)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide chemical structure, C25H21ClN6O4S, CAS 257876-25-8

N-(6-Chloro-2-(2-cyanopyridin-4-yl)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide

CAS 257876-25-8C₂₅H₂₁ClN₆O₄S