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Murcko scaffold

Ring system with 4 rings and 25 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
9
With full pages
1
Scaffold SMILES

O=C(C(=Cc1ccccc1)c1nc2ccccc2[nH]1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C(=Cc1ccccc1)c1nc2ccccc2[nH]1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

(E)-2-(1H-Benzimidazol-2-yl)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one chemical structure, C22H15N3O3, CAS 263358-54-9
(E)-2-(1H-Benzimidazol-2-yl)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one
CAS 263358-54-9C22H15N3O3
(E)-2-(1H-Benzimidazol-2-yl)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one chemical structure, C22H15ClN2O, CAS 303787-69-1
(E)-2-(1H-Benzimidazol-2-yl)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one
CAS 303787-69-1C22H15ClN2O
3-[4-(Dimethylamino)phenyl]-1-phenyl-2-[1-(trifluoromethyl)-1H-benzimidazol-2-yl]-2-propen-1-one chemical structure, C25H20F3N3O, CAS 874595-16-1
3-[4-(Dimethylamino)phenyl]-1-phenyl-2-[1-(trifluoromethyl)-1H-benzimidazol-2-yl]-2-propen-1-one
CAS 874595-16-1C25H20F3N3O
(2R)-N'-[5-[(E)-2-(1H-Benzimidazol-2-yl)-3-(2,5-difluorophenyl)-1-hydroxy-3-oxoprop-1-enyl]-2-fluorophenyl]sulfonyl-2-hydroxypropanimidamide chemical structure, C25H19F3N4O5S
(2R)-N'-[5-[(E)-2-(1H-Benzimidazol-2-yl)-3-(2,5-difluorophenyl)-1-hydroxy-3-oxoprop-1-enyl]-2-fluorophenyl]sulfonyl-2-hydroxypropanimidamide
C25H19F3N4O5S
Opigolix chemical structure, C25H19F3N4O5S, CAS 912587-25-8
Opigolix
CAS 912587-25-8C25H19F3N4O5S
(2R)-N'-[5-[2-(1H-Benzimidazol-2-yl)-3-(2,5-difluorophenyl)-1-hydroxy-3-oxoprop-1-enyl]-2-fluorophenyl]sulfonyl-2-hydroxypropanimidamide chemical structure, C25H19F3N4O5S
(2R)-N'-[5-[2-(1H-Benzimidazol-2-yl)-3-(2,5-difluorophenyl)-1-hydroxy-3-oxoprop-1-enyl]-2-fluorophenyl]sulfonyl-2-hydroxypropanimidamide
C25H19F3N4O5S
5-(3-(2,5-Difluorophenyl)-2-(1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)-3-oxopropanoyl)-2-fluorobenzenesulfonyl chloride chemical structure, C22H12ClF3N2O4S, CAS 912579-68-1
5-(3-(2,5-Difluorophenyl)-2-(1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)-3-oxopropanoyl)-2-fluorobenzenesulfonyl chloride
CAS 912579-68-1C22H12ClF3N2O4S
N'-[5-[2-(1H-Benzimidazol-2-yl)-3-(2,5-difluorophenyl)-1-hydroxy-3-oxoprop-1-enyl]-2-fluorophenyl]sulfonyl-2-hydroxypropanimidamide chemical structure, C25H19F3N4O5S
N'-[5-[2-(1H-Benzimidazol-2-yl)-3-(2,5-difluorophenyl)-1-hydroxy-3-oxoprop-1-enyl]-2-fluorophenyl]sulfonyl-2-hydroxypropanimidamide
C25H19F3N4O5S
Opigolix chemical structure, C25H19F3N4O5S
Opigolix
C25H19F3N4O5S