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Impurities and reference standards

13-Hydroxyberberine

Also known as 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo(11.8.0.02,10.04,8.015,20)henicosa-1(13),2,4(8),9,14,16,18,20-octaen-21-ol, chloride, 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-21-ol, chloride, Berberine impurity 25

CAS 7664-25-7Formula C20H18ClNO5Molar mass 387.82 g/mol
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13-Hydroxyberberine chemical structure, C20H18ClNO5, CAS 7664-25-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
7664-25-7
Formula
C20H18ClNO5
Molar mass
387.82 g/mol
HS code
293499
Category
Impurities and reference standards

What is 13-Hydroxyberberine?

Plain description, key identifiers and synonyms

13-Hydroxyberberine is a chemical substance with the molecular formula C20H18ClNO5 and a molar mass of 387.82 g/mol. Its CAS registry number is 7664-25-7. The IUPAC name is 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-21-ol chloride.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-21-ol chloride
CAS number
7664-25-7
Molecular formula
C20H18ClNO5
InChIKey
SAFQLLBOPKXYLB-UHFFFAOYSA-N
InChI
InChI=1S/C20H17NO5.ClH/c1-23-15-4-3-12-14(20(15)24-2)9-21-6-5-11-7-16-17(26-10-25-16)8-13(11)18(21)19(12)22;/h3-4,7-9H,5-6,10H2,1-2H3;1H
SMILES (canonical and isomeric)
COC1=C(C2=C[N+]3=C(C4=CC5=C(C=C4CC3)OCO5)C(=C2C=C1)O)OC.[Cl-]

Synonyms

  • 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo(11.8.0.02,10.04,8.015,20)henicosa-1(13),2,4(8),9,14,16,18,20-octaen-21-ol, chloride
  • 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-21-ol, chloride
  • Berberine impurity 25
  • Berberine Impurity 12 Chloride

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
387.82 g/molcalc.
Exact mass
387.0874 Dacalc.
LogP (octanol/water)
-0.19calc.
Topological polar surface area
61.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
27calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c[n+]3c(cc2c1)-c1cc2c(cc1CC3)OCO2

c1ccc2c[n+]3c(cc2c1)-c1cc2c(cc1CC3)OCO2

5 rings, 21 atoms.

40 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

13-Hydroxyberberine suppliers

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13-Hydroxyberberine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 13-Hydroxyberberine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 13-Hydroxyberberine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 13-Hydroxyberberine, based on the data on this page

What is 13-Hydroxyberberine?

13-Hydroxyberberine is a chemical substance with the molecular formula C20H18ClNO5 and a molar mass of 387.82 g/mol. Its CAS registry number is 7664-25-7. The IUPAC name is 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-21-ol chloride.

What is the CAS number of 13-Hydroxyberberine?

The CAS registry number of 13-Hydroxyberberine is 7664-25-7.

What is the molecular formula and weight of 13-Hydroxyberberine?

The molecular formula of 13-Hydroxyberberine is C20H18ClNO5 and its molar mass is 387.82 g/mol.

Is 13-Hydroxyberberine hazardous?

No GHS hazard classification for 13-Hydroxyberberine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of 13-Hydroxyberberine?

13-Hydroxyberberine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 13-Hydroxyberberine?

Post a free request on CompoundList and suppliers of 13-Hydroxyberberine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of 13-Hydroxyberberine?

Suppliers quote 13-Hydroxyberberine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 13-Hydroxyberberine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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