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Pharmaceuticals and APIs

4-Hydroxycyclophosphamide

Also known as Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide, 2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide, 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphosphinan-4-ol 2-oxide

CAS 40277-05-2Formula C7H15Cl2N2O3PMolar mass 277.09 g/mol
1 supplier listed Drug substance
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4-Hydroxycyclophosphamide chemical structure, C7H15Cl2N2O3P, CAS 40277-05-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
40277-05-2
Formula
C7H15Cl2N2O3P
Molar mass
277.09 g/mol
HS code
293499
Category
Pharmaceuticals and APIs

What is 4-Hydroxycyclophosphamide?

Plain description, key identifiers and synonyms

4-hydroxycyclophosphamide is a phosphorodiamide that consists of 2-amino-1,3,2-oxazaphosphinan-4-ol 2-oxide having two 2-chloroethyl groups attached to the exocyclic nitrogen. It has a role as an alkylating agent and a metabolite. It is a phosphorodiamide, an organochlorine compound and a nitrogen mustard.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-4-ol
CAS number
40277-05-2 CAS number cross-checkedOther or deprecated CAS: 61903-30-8
Molecular formula
C7H15Cl2N2O3P
UNII
1XBF4E50HS
InChIKey
RANONBLIHMVXAJ-UHFFFAOYSA-N
InChI
InChI=1S/C7H15Cl2N2O3P/c8-2-4-11(5-3-9)15(13)10-7(12)1-6-14-15/h7,12H,1-6H2,(H,10,13)
SMILES (canonical and isomeric)
C1COP(=O)(NC1O)N(CCCl)CCCl

Synonyms

  • Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
  • 2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
  • 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphosphinan-4-ol 2-oxide
  • 2-(bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinan-4-ol 2-oxide
  • 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-ol
  • 2-(Bis(2-chloroethyl)amino)-4-hydroxy-1,3,2-oxazaphosphinane 2-oxide
  • (R,S)-4-Hydroxy Cyclophosphamide
  • (R,S)-4-Hydroxy Cyclophosphamide Preparation Kit
  • C7H15Cl2N2O3P
  • 2H-1,3,2-Oxazaphosphorin-4-ol, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide
  • 2H-1,3,2-Oxazaphosphorin-4-ol, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide
  • 2-(Bis(2-chloroethyl)amino)-4-hydroxy-1,3,2-oxazaphosphinane2-oxide
  • 2-[Bis(2-chloroethyl)amino]-4-hydroxy-1,3,2lambda~5~-oxazaphosphinan-2-one
  • 2H-1,2-Oxazaphosphorin-4-ol, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
277.09 g/molcalc.
Exact mass
276.0197 Dacalc.
LogP (octanol/water)
1.2calc.
Topological polar surface area
61.8 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
5calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=[PH]1NCCCO1

O=[PH]1NCCCO1

1 ring, 7 atoms.

197 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

4-Hydroxycyclophosphamide suppliers

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Where suppliers are based

1 supplier in 1 country

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4-Hydroxycyclophosphamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • aetiopathogenetic role
  • alkylating agent
  • genotoxin
  • metabolite
  • mutagen

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 4-Hydroxycyclophosphamide is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for 4-Hydroxycyclophosphamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 4-Hydroxycyclophosphamide, based on the data on this page

What is 4-Hydroxycyclophosphamide?

4-hydroxycyclophosphamide is a phosphorodiamide that consists of 2-amino-1,3,2-oxazaphosphinan-4-ol 2-oxide having two 2-chloroethyl groups attached to the exocyclic nitrogen. It has a role as an alkylating agent and a metabolite. It is a phosphorodiamide, an organochlorine compound and a nitrogen mustard.

What is the CAS number of 4-Hydroxycyclophosphamide?

The CAS registry number of 4-Hydroxycyclophosphamide is 40277-05-2. Other or deprecated CAS numbers: 61903-30-8.

What is the molecular formula and weight of 4-Hydroxycyclophosphamide?

The molecular formula of 4-Hydroxycyclophosphamide is C7H15Cl2N2O3P and its molar mass is 277.09 g/mol.

What is 4-Hydroxycyclophosphamide used for?

Known uses and roles of 4-Hydroxycyclophosphamide include aetiopathogenetic role, alkylating agent, genotoxin, metabolite and mutagen.

Is 4-Hydroxycyclophosphamide hazardous?

No GHS hazard classification for 4-Hydroxycyclophosphamide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of 4-Hydroxycyclophosphamide?

4-Hydroxycyclophosphamide is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 4-Hydroxycyclophosphamide?

CompoundList lists 1 supplier of 4-Hydroxycyclophosphamide in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of 4-Hydroxycyclophosphamide?

Suppliers quote 4-Hydroxycyclophosphamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 4-Hydroxycyclophosphamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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