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Insecticides and acaricides

4-Nitrophenol

Also known as p-nitrophenol, Phenol, 4-nitro-, Paranitrophenol

CAS 100-02-7Formula C6H5NO3Molar mass 139.11 g/molEC 202-811-7
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 96 suppliers listed
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4-Nitrophenol chemical structure, C6H5NO3, CAS 100-02-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless to slightly yellow crystals
Melting point
113 to 114
Boiling point
279 ยฐC
Density
1.479 g/cmยณ at 20 ยฐC
Flash point
169 ยฐC
HS code
290899
Category
Insecticides and acaricides
UN number
UN 1663
Illustrative photo, colourless crystals beside a jumbo bulk bag in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is 4-Nitrophenol?

Plain description, key identifiers and synonyms

4-nitrophenol is a member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group. It has a role as a mouse metabolite and a human xenobiotic metabolite. It is a conjugate acid of a 4-nitrophenolate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-nitrophenol
CAS number
100-02-7 CAS number cross-checked
EC number
202-811-7
Molecular formula
C6H5NO3
UNII
Y92ZL45L4R
MDL number
MFCD00007331
InChIKey
BTJIUGUIPKRLHP-UHFFFAOYSA-N
InChI
InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H
SMILES (canonical and isomeric)
C1=CC(=CC=C1[N+](=O)[O-])O

Synonyms

  • p-nitrophenol
  • Phenol, 4-nitro-
  • Paranitrophenol
  • Niphen
  • 4-Hydroxynitrobenzene
  • p-Hydroxynitrobenzene
  • para-nitrophenol
  • Phenol, p-nitro-
  • Paranitrofenol
  • Paranitrofenolo
  • 4-Nitrofenol
  • 1-Hydroxy-4-nitrobenzene
  • 4-Hydroxy-1-nitrobenzene
  • Mononitrophenol
  • p-Nitrofenol
  • RCRA waste number U170
  • PNP
  • 4-nitro-phenol
  • RCRA waste no. U170
  • NPO
  • p-nitro phenol
  • 4-nitryl phenol
  • 4- nitrophenol
  • 4-nitro phenol
  • 4-nitrophenol-
Show all 31 synonyms
  • 3qvu
  • RPN
  • Nitrophenol, p-
  • Phenol,4-nitro
  • 4-Nitrophenol (NIST)
  • Acetaminophen EP Impurity F

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless to slightly yellow crystalsexp.
Odour
Odorlessexp.
Taste
Sweetish, then burning tasteexp.
Melting point
113 to 114exp.
Boiling point
279 ยฐCexp.
Density
1.479 g/cmยณ at 20 ยฐCexp.
Flash point
169 ยฐCexp.
Autoignition temperature
490 ยฐCexp.
Solubility
Solubility in water, 269,000 mg/L at 90 ยฐCexp.
Vapour pressure
9.79 ร— 10โปโต mm Hg at 20 ยฐC, 5 ร— 10โปโด mm Hg at 25 ยฐC /Extrapolated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
139.11 g/molcalc.
Exact mass
139.0269 Dacalc.
LogP (octanol/water)
1.3calc.
Topological polar surface area
63.37 ร…ยฒcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
10calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (15)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1663
Transport hazard class
6.1
Packing group
III

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

4-Nitrophenol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 96 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

96 suppliers in 20 countries

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4-Nitrophenol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Manufacture of pharmaceuticals, fungicides, dyes. Indicator in 0.1% alcohol solution. pH: 5.6 colorless, 7.6 yellow.

Chem intermediate for the insecticides methyl parathion & ethyl parathion, azo & sulfur dyes, n-acetyl-p-aminophenol, chem intermediate for leather preservatives.

As substrate for analysis of UDP-glucuronyl transferase.

4-Nitrophenol is used to manufacture drugs (e.g., acetaminophen), fungicides, methyl and ethyl parathion insecticides, and dyes and to darken leather.

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • human xenobiotic metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite
  • xenobiotic metabolite

How it is made

4-Nitrophenol is produced either by the catalytic hydrolysis of 4-nitrochlorobenzene or by the reaction of dilute nitric acid on phenol and subsequent steam distillation to separate the 4- from the 2-isomer.

Action of dilute nitric acid on phenol at low temperature, ... Separated (from o-nitrophenol) by steam distillation.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 609-015-00-2

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 4-Nitrophenol is traded under.

HS 2908.99Indicative HS code

Halogenated, sulphonated, nitrated or nitrosated derivatives of phenols orโ€ฆ

World exports in 2024
$77.7M
+4.6% vs 2023, imports $83.7M
2019 to 2024
Top exporters
  1. China32.2%
  2. India * partner reported22.2%
  3. Spain8.5%
Top importers
  1. United States13.9%
  2. Spain10.6%
  3. Turkey8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 4-Nitrophenol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 4-Nitrophenol, based on the data on this page

What is 4-Nitrophenol?

4-nitrophenol is a member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group. It has a role as a mouse metabolite and a human xenobiotic metabolite. It is a conjugate acid of a 4-nitrophenolate.

What is the CAS number of 4-Nitrophenol?

The CAS registry number of 4-Nitrophenol is 100-02-7.

What is the molecular formula and weight of 4-Nitrophenol?

The molecular formula of 4-Nitrophenol is C6H5NO3 and its molar mass is 139.11 g/mol.

What is 4-Nitrophenol used for?

Manufacture of pharmaceuticals, fungicides, dyes. Indicator in 0.1% alcohol solution. pH: 5.6 colorless, 7.6 yellow. Chem intermediate for the insecticides methyl parathion & ethyl parathion, azo & sulfur dyes, n-acetyl-p-aminophenol, chem intermediate for leather preservatives.

Is 4-Nitrophenol hazardous?

4-Nitrophenol carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 4-Nitrophenol?

4-Nitrophenol is usually classified under HS code 290899 (Halogenated, sulphonated, nitrated or nitrosated derivatives of phenols orโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 4-Nitrophenol?

CompoundList lists 96 suppliers of 4-Nitrophenol in China, United States, India, Germany and 16 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 4-Nitrophenol in India?

8 suppliers in India list 4-Nitrophenol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 4-Nitrophenol?

Suppliers quote 4-Nitrophenol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 4-Nitrophenol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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