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Steroids and sterols

6alpha-Hydroxyestradiol

Also known as 6alpha-hydroxy-17beta-estradiol, estra-1,3,5(10)-triene-3,6alpha,17beta-triol, Estra-1,3,5(10)-triene-3,6,17-triol, (6alpha,17beta)-

CAS 1229-24-9Formula C18H24O3Molar mass 288.39 g/molEC 634-140-4
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard
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6alpha-Hydroxyestradiol chemical structure, C18H24O3, CAS 1229-24-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1229-24-9
Formula
C18H24O3
Molar mass
288.39 g/mol
EC number
634-140-4
HS code
290729
Category
Steroids and sterols

What is 6alpha-Hydroxyestradiol?

Plain description, key identifiers and synonyms

6alpha-hydroxy-17beta-estradiol is a 4-hydroxy steroid that consists of 17beta-estradiol bearing an additional 6alpha-hydroxy substituent. It is functionally related to a 17beta-estradiol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6S,8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,6,17-triol
CAS number
1229-24-9 CAS number cross-checked
EC number
634-140-4
Molecular formula
C18H24O3
UNII
IL75Q4KU3Q
InChIKey
QZZRQURPSRWTLG-WOVZSMEKSA-N
InChI
InChI=1S/C18H24O3/c1-18-7-6-12-11-3-2-10(19)8-14(11)16(20)9-13(12)15(18)4-5-17(18)21/h2-3,8,12-13,15-17,19-21H,4-7,9H2,1H3/t12-,13-,15+,16+,17+,18+/m1/s1
Canonical SMILES
CC12CCC3c4ccc(O)cc4C(O)CC3C1CCC2O
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)C[C@@H](C4=C3C=CC(=C4)O)O

Synonyms

  • 6alpha-hydroxy-17beta-estradiol
  • estra-1,3,5(10)-triene-3,6alpha,17beta-triol
  • Estra-1,3,5(10)-triene-3,6,17-triol, (6alpha,17beta)-
  • 1,3,5-Estratriene-3,6alpha,17beta-triol
  • 6a-Hydroxy 17b-Estradiol
  • 6|A-Hydroxyestradiol
  • 6alpha-hydroxy-estradiol
  • (6S,8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,6,17-triol
  • (1S,3aS,3bR,5S,9bS,11aS)-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1,5,7-triol
  • 6alpha-Hydroxy 17beta-Estradiol
  • 6-alpha-Hydroxy Estradiol
  • 6alpha-Hydroxyestradiol, analytical standard
  • Estra-1,3,5(10)-triene-3,6,17-triol #
  • (6alpha,17beta)-estra-1,3,5(10)-triene-3,6,17-triol
  • Estra-1,3,5(10)-triene-3,6,17-triol, (6|A,17|A)-
  • (6S,8R,9S,13S,14S,17S)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,6,17-triol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
288.39 g/molcalc.
Exact mass
288.1725 Dacalc.
LogP (octanol/water)
3.1calc.
Topological polar surface area
60.69 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
21calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCC1C2CCC2CCCC21

c1ccc2c(c1)CCC1C2CCC2CCCC21

4 rings, 17 atoms.

585 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H335May cause respiratory irritation.
  • H351Suspected of causing cancer.
Precautionary statements (22)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

6alpha-Hydroxyestradiol suppliers

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6alpha-Hydroxyestradiol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 6alpha-Hydroxyestradiol is traded under.

HS 2907.29Indicative HS code

Polyphenols, phenol-alcohols, other

World exports in 2024
$535M
−27.0% vs 2023, imports $565M
2019 to 2024
Top exporters
  1. India * partner reported17.7%
  2. Germany16.5%
  3. Japan15.8%
Top importers
  1. United States13.1%
  2. Japan8.0%
  3. Belgium7.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 6alpha-Hydroxyestradiol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 6alpha-Hydroxyestradiol, based on the data on this page

What is 6alpha-Hydroxyestradiol?

6alpha-hydroxy-17beta-estradiol is a 4-hydroxy steroid that consists of 17beta-estradiol bearing an additional 6alpha-hydroxy substituent. It is functionally related to a 17beta-estradiol.

What is the CAS number of 6alpha-Hydroxyestradiol?

The CAS registry number of 6alpha-Hydroxyestradiol is 1229-24-9.

What is the molecular formula and weight of 6alpha-Hydroxyestradiol?

The molecular formula of 6alpha-Hydroxyestradiol is C18H24O3 and its molar mass is 288.39 g/mol.

Is 6alpha-Hydroxyestradiol hazardous?

6alpha-Hydroxyestradiol carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 6alpha-Hydroxyestradiol?

6alpha-Hydroxyestradiol is usually classified under HS code 290729 (Polyphenols, phenol-alcohols, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 6alpha-Hydroxyestradiol?

Post a free request on CompoundList and suppliers of 6alpha-Hydroxyestradiol will send you quotes. Your contact details stay private until you accept a quote.

What is the price of 6alpha-Hydroxyestradiol?

Suppliers quote 6alpha-Hydroxyestradiol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 6alpha-Hydroxyestradiol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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