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Hormones and steroids

Estriol

Also known as Oestriol, Trihydroxyestrin, Aacifemine

CAS 50-27-1Formula C18H24O3Molar mass 288.39 g/molEC 200-022-2
GHS signal word: Danger. Pictograms: Serious health hazard, Hazardous to the environment 103 suppliers listed Drug substance
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Estriol chemical structure, C18H24O3, CAS 50-27-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Leaflets from alcohol
Melting point
288 °C
Density
1.27 g/cm³ at 25 °C
Solubility
In double-distilled water, 13.25 mg/L
HS code
293723
Category
Hormones and steroids
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Estriol?

Plain description, key identifiers and synonyms

Estriol is a 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer). It has a role as an estrogen, a mouse metabolite, a human xenobiotic metabolite and a human metabolite. It is a 16alpha-hydroxy steroid, a 17beta-hydroxy steroid and a 3-hydroxy steroid. It derives from a hydride of an estrane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
CAS number
50-27-1 CAS number cross-checked
EC number
200-022-2
Molecular formula
C18H24O3
UNII
FB33469R8E
MDL number
MFCD00003691
InChIKey
PROQIPRRNZUXQM-ZXXIGWHRSA-N
InChI
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
Canonical SMILES
CC12CCC3c4ccc(O)cc4CCC3C1CC(O)C2O
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=C3C=CC(=C4)O

Synonyms

  • Oestriol
  • Trihydroxyestrin
  • Aacifemine
  • Estratriol
  • Ovestrion
  • Tridestrin
  • Destriol
  • Ovestin
  • Theelol
  • Hormomed
  • Klimoral
  • Oestratriol
  • Orestin
  • Triovex
  • Ortho-Gynest
  • Hemostyptanon
  • Oestriolum
  • Overstin
  • 16alpha-Hydroxyestradiol
  • Deuslon-A
  • Estriel
  • 16alpha,17beta-Estriol
  • Colpogyn
  • 16-alpha-Hydroxyestradiol
  • 16alpha-Hydroxy-17beta-estradiol
Show all 39 synonyms
  • 16alpha-Hydroxyoestradiol
  • 16alpha,17beta-Oestriol
  • Incurin
  • 16-alpha,17-beta-Estriol
  • 16-alpha,17-beta-Oestriol
  • (16alpha,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol
  • 3,16alpha,17beta-Estriol
  • Ovesterin
  • Ovo-vinces
  • Klimax E
  • 3,16alpha,17beta-Trihydroxy-1,3,5(10)-estratriene
  • Estra-1,3,5(10)-triene-3,16alpha,17beta-triol
  • Colpovister
  • OeKolp

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Leaflets from alcoholexp.
Odour
Odorlessexp.
Melting point
288 °Cexp.
Density
1.27 g/cm³ at 25 °Cexp.
Solubility
In double-distilled water, 13.25 mg/Lexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
288.39 g/molcalc.
Exact mass
288.1725 Dacalc.
LogP (octanol/water)
2.58calc.
Topological polar surface area
60.69 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
21calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCC1C2CCC2CCCC21

c1ccc2c(c1)CCC1C2CCC2CCCC21

4 rings, 17 atoms.

585 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H350May cause cancer.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (12)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Estriol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 103 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

103 suppliers in 15 countries

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Estriol price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Roles

  • agonist
  • animal metabolite
  • estrogen
  • eukaryotic metabolite
  • hormone
  • human metabolite
  • human xenobiotic metabolite
  • immunomodulator
  • immunosuppressive agent
  • mammalian metabolite
  • metabolite
  • molecular messenger
  • mouse metabolite
  • pharmaceutical
  • sex hormone
  • xenobiotic metabolite

Pharmacology

Estriol is a synthetic form of the endogenous human estriol, a weak oestrogen and natural metabolite of estradiol, that can be used for hormone replacement. Upon administration, estriol maintains adequate levels of estrogen, binds to estrogen receptors, and relieves symptoms caused by estrogen deficiency.

How it is made

Isolation from pregnant human urine, isolated from human placenta, organic synthesis.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Estriol is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Estriol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Estriol, based on the data on this page

What is Estriol?

Estriol is a 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer). It has a role as an estrogen, a mouse metabolite, a human xenobiotic metabolite and a human metabolite.

What is the CAS number of Estriol?

The CAS registry number of Estriol is 50-27-1.

What is the molecular formula and weight of Estriol?

The molecular formula of Estriol is C18H24O3 and its molar mass is 288.39 g/mol.

What is Estriol used for?

Use classes: Animal Drugs.

Is Estriol hazardous?

Estriol carries the GHS signal word "Danger". Main hazards: may cause cancer, suspected of causing cancer, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Estriol?

Estriol is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Estriol?

CompoundList lists 103 suppliers of Estriol in China, United States, Germany, Canada and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Estriol in India?

4 suppliers in India list Estriol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Estriol?

Suppliers quote Estriol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Estriol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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