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Cardiovascular and metabolic drugs

Acetazolamide

Also known as Acetamox, Glaupax, N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

CAS 59-66-5Formula C4H6N4O3S2Molar mass 222.25 g/molEC 200-440-5
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 138 suppliers listed Drug substance
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Acetazolamide chemical structure, C4H6N4O3S2, CAS 59-66-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from water
Melting point
258 to 259
Solubility
SPARINGLY SOL IN COLD WATER
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Acetazolamide?

Plain description, key identifiers and synonyms

Acetazolamide is a monocarboxylic acid amide, a sulfonamide and a member of thiadiazoles. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, a diuretic and an anticonvulsant. It is a conjugate acid of an acetazolamide(1-). It derives from a hydride of a 1,3,4-thiadiazole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
CAS number
59-66-5 CAS number cross-checkedOther or deprecated CAS: 124442-28-0
EC number
200-440-5
Molecular formula
C4H6N4O3S2
UNII
O3FX965V0I
MDL number
MFCD00003105
InChIKey
BZKPWHYZMXOIDC-UHFFFAOYSA-N
InChI
InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
SMILES (canonical and isomeric)
CC(=O)NC1=NN=C(S1)S(=O)(=O)N

Synonyms

  • Acetamox
  • Glaupax
  • N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
  • Edemox
  • Acetazolamid
  • Defiltran
  • Nephramide
  • Diacarb
  • Donmox
  • Cidamex
  • Diluran
  • Phonurit
  • Didoc
  • Dehydratin
  • Diuramid
  • Diuriwas
  • Diutazol
  • Diakarb
  • Natrionex
  • Nephramid
  • Duiramid
  • Eumicton
  • Fonurit
  • Glupax
  • 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide
Show all 39 synonyms
  • Acetazolamida
  • Acetazolamidum
  • Acetazoleamide
  • Diureticum-holzinger
  • Acetamidothiadiazolesulfonamide
  • 4-Diamox
  • Atenezo
  • Acetamide, N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-
  • Carbonic Anhydrase Inhibitor No. 6063
  • 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide
  • 2-Acetamido-5-sulfonamido-1,3,4-thiadiazole
  • N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
  • 1,3,4-Thiadiazole-2-sulfonamide, 5-acetamido-
  • 5-Acetamide-1,3,4-thiadiazole-2-sulfonamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from waterexp.
Odour
ODORLESSexp.
Melting point
258 to 259exp.
Solubility
SPARINGLY SOL IN COLD WATERexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
222.25 g/molcalc.
Exact mass
221.9881 Dacalc.
LogP (octanol/water)
-0.86calc.
Topological polar surface area
115 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
2calc.
Heavy atoms
13calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1nncs1

c1nncs1

1 ring, 5 atoms, the 1,3,4-Thiadiazole ring system.

1,661 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H361dSuspected of damaging the unborn child.
Precautionary statements (13)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Acetazolamide suppliers

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All 138 suppliers
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Where suppliers are based

138 suppliers in 23 countries

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Acetazolamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anticonvulsants
  • Carbonic Anhydrase Inhibitors
  • Diuretics

Roles

  • analgesic
  • antibacterial agent
  • anticonvulsant
  • antiglaucoma drug
  • antihypertensive agent
  • antimicrobial agent
  • antineoplastic agent
  • antipsychotic agent
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • diuretic
  • enzyme inhibitor
  • hypoglycemic agent
  • immunomodulator
  • immunosuppressive agent
  • ophthalmology drug
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • renoprotective agent
  • tranquilizing drug
  • vasoconstrictor agent

Functional uses

  • Pharmaceutical

Pharmacology

Acetazolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor.

How it is made

Reaction of hydrazine hydrate with ammonium thiocyanate, to produce 5-amino-2-mercapto-1,3,4-thiadiazole, which is acetylated and oxidized, then amidated with ammonia

Hydrazine + ammonium thiocyanate + acetic anhydride + ammonia (thiocyanate addition/cyclization/acetylation/oxidation/sulfonamide formation)

Oxidative chlorination of 2-acetyl-amino-5-mercapto-1,3,4-thiadiazole or its S-benzyl or S-acyl derivatives to the corresponding sulfonyl chlorides followed by reaction with ammonia has proved to be an optimal method for the synthesis of acetazolamide.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Acetazolamide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Acetazolamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Acetazolamide, based on the data on this page

What is Acetazolamide?

Acetazolamide is a monocarboxylic acid amide, a sulfonamide and a member of thiadiazoles. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, a diuretic and an anticonvulsant. It is a conjugate acid of an acetazolamide(1-). It derives from a hydride of a 1,3,4-thiadiazole.

What is the CAS number of Acetazolamide?

The CAS registry number of Acetazolamide is 59-66-5. Other or deprecated CAS numbers: 124442-28-0.

What is the molecular formula and weight of Acetazolamide?

The molecular formula of Acetazolamide is C4H6N4O3S2 and its molar mass is 222.25 g/mol.

What is Acetazolamide used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Acetazolamide hazardous?

Acetazolamide carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, suspected of damaging the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Acetazolamide?

Acetazolamide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Acetazolamide?

CompoundList lists 138 suppliers of Acetazolamide in United States, China, India, Germany and 19 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Acetazolamide in India?

19 suppliers in India list Acetazolamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Acetazolamide?

Suppliers quote Acetazolamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Acetazolamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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