CompoundList
Sign in
Other active pharmaceutical ingredients

Acitretin

Also known as Etretin, Soriatane, Neotigason

CAS 55079-83-9Formula C21H26O3Molar mass 326.44 g/molEC 259-474-4
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 135 suppliers listed Drug substance
Get quotes Compare 135 suppliers
Acitretin chemical structure, C21H26O3, CAS 55079-83-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Green-yellow crystalline powder
Melting point
228 to 230
Solubility
Practically insoluble in water (<0.1 mg/100 mg)
HS code
291899
Category
Other active pharmaceutical ingredients
Illustrative photo, green pigment powder in a glass jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Acitretin?

Plain description, key identifiers and synonyms

All-trans-acitretin is a retinoid, an acitretin and an alpha,beta-unsaturated monocarboxylic acid. It has a role as a keratolytic drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
CAS number
55079-83-9 CAS number cross-checkedOther or deprecated CAS: 419534-31-9, 54757-46-9
EC number
259-474-4
Molecular formula
C21H26O3
UNII
LCH760E9T7
MDL number
MFCD00866632
InChIKey
IHUNBGSDBOWDMA-AQFIFDHZSA-N
InChI
InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
Canonical SMILES
COc1cc(C)c(C=CC(C)=CC=CC(C)=CC(=O)O)c(C)c1C
Isomeric SMILES
CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C)C)C)OC

Synonyms

  • Etretin
  • Soriatane
  • Neotigason
  • Acitretine
  • (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
  • Acitretina
  • Ro 10-1670
  • Ro 10-1670/000
  • (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
  • Ro-10-1670
  • all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid
  • Ro-10-1670/000
  • 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, (all-E)-
  • 2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-, (all-E)-
  • Trimethylmethoxyphenyl-retinoic acid
  • Ro 101670
  • Ro 137652
  • all-trans-Acitretin
  • Retinoid etretin
  • Acitretinum
  • 9-cis Acitretin
  • 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
  • (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid
  • (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
  • Acetretin
Show all 32 synonyms
  • Soriatane CK
  • Soriatane (TN)
  • Isoacitretin, Ro 13-7652
  • Neotigason,
  • Etretin,
  • Acitretin CRS
  • all-trans-Etretin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Green-yellow crystalline powderexp.
Melting point
228 to 230exp.
Solubility
Practically insoluble in water (<0.1 mg/100 mg)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
326.44 g/molcalc.
Exact mass
326.1882 Dacalc.
LogP (octanol/water)
5.17calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
6calc.
Heavy atoms
24calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H360May damage fertility or the unborn child.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (15)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Acitretin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 135 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

135 suppliers in 24 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Acitretin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Keratolytic Agents.

Pharmacological actions

  • Keratolytic Agents

Roles

  • dermatologic drug
  • keratolytic drug
  • pharmaceutical

Pharmacology

Acitretin is an orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04)

How it is made

Preparation ... W. Bollag et al., German patent 2414619, eidem, United States of America patent 4105681 (1974, 1978 both to Hoffmann-La Roche).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Acitretin is traded under.

HS 2918.99Indicative HS code

Carboxylic acids, with additional oxygen function (not alcohol, phenol, aldehyde or ketone)…

World exports in 2024
$1.46B
−1.1% vs 2023, imports $1.54B
2019 to 2024
Top exporters
  1. China40.0%
  2. India * partner reported26.6%
  3. Germany8.0%
Top importers
  1. United States25.6%
  2. Brazil6.7%
  3. Argentina5.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Acitretin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Acitretin, based on the data on this page

What is Acitretin?

All-trans-acitretin is a retinoid, an acitretin and an alpha,beta-unsaturated monocarboxylic acid. It has a role as a keratolytic drug.

What is the CAS number of Acitretin?

The CAS registry number of Acitretin is 55079-83-9. Other or deprecated CAS numbers: 419534-31-9, 54757-46-9.

What is the molecular formula and weight of Acitretin?

The molecular formula of Acitretin is C21H26O3 and its molar mass is 326.44 g/mol.

What is Acitretin used for?

Keratolytic Agents.

Is Acitretin hazardous?

Acitretin carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye irritation, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Acitretin?

Acitretin is usually classified under HS code 291899 (Carboxylic acids with additional oxygen function and their anhydrides, halides…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Acitretin?

CompoundList lists 135 suppliers of Acitretin in China, United States, India, Germany and 20 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Acitretin in India?

20 suppliers in India list Acitretin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Acitretin?

Suppliers quote Acitretin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Acitretin

Get quotes for Acitretin

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Acitretin
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Acitretin with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/acitretin-55079-83-9" title="Acitretin structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Other active pharmaceutical ingredients or HS code 291899

135 suppliers
Free quotes, contact stays private
Get quotes