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Cardiovascular and metabolic drugs

Adehl

Also known as Colforsin daropate hydrochloride, Colforsin dapropate hydrochloride, Colforsin dapropate HCl

CAS 138605-00-2Formula C27H44ClNO8Molar mass 546.10 g/molEC 689-002-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 1 supplier listed
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Adehl chemical structure, C27H44ClNO8, CAS 138605-00-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
138605-00-2
Formula
C27H44ClNO8
Molar mass
546.10 g/mol
EC number
689-002-6
HS code
293299
Category
Cardiovascular and metabolic drugs

What is Adehl?

Plain description, key identifiers and synonyms

Colforsin daropate hydrochloride is the hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP. It has a role as a vasodilator agent, an antihypertensive agent, a cardiotonic drug and an adenylate cyclase agonist. It contains a colforsin daropate(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 3-(dimethylamino)propanoate, hydrochloride
CAS number
138605-00-2 CAS number cross-checked
EC number
689-002-6
Molecular formula
C27H44ClNO8
UNII
C6P4R272GT
MDL number
MFCD00236421
InChIKey
VIRRLEDAYYYTOD-YHEOSNBFSA-N
InChI
InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
Canonical SMILES
C=CC1(C)CC(=O)C2(O)C(C)(O1)C(OC(C)=O)C(OC(=O)CCN(C)C)C1C(C)(C)CCC(O)C12C.Cl
Isomeric SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)OC(=O)CCN(C)C.Cl

Synonyms

  • Colforsin daropate hydrochloride
  • Colforsin dapropate hydrochloride
  • Colforsin dapropate HCl
  • 6-(3-Dimethylaminopropionyl)forskolin hydrochloride
  • colforsin daropate HCl
  • NKH477 (hydrochloride)
  • Colforsin daropate hydrochloride (JAN)
  • Adehl (TN)
  • Colforsin daropate hci
  • C27H44ClNO8
  • Colforsin daproate hydrochloride
  • NKH 477, >=98% (HPLC), powder
  • N,N-Dimethyl-colforsin dapropate hydrochloride

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
546.10 g/molcalc.
Exact mass
545.2755 Dacalc.
LogP (octanol/water)
2.44calc.
Topological polar surface area
122.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
6calc.
Heavy atoms
37calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.82calc.
Formal charge
0calc.
Stereocentres
8calc.
Components
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCOC2CCC3CCCCC3C12

O=C1CCOC2CCC3CCCCC3C12

3 rings, 15 atoms.

27 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Adehl suppliers

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  • Hello Bio
    United Kingdom, AvonmouthUnclaimed profile
    AdehlGrade, purity and minimum order on request
    Price on request
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Where suppliers are based

1 supplier in 1 country

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Adehl price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • adenylate cyclase agonist
  • agonist
  • antihypertensive agent
  • cardiotonic drug
  • cardiovascular drug
  • pharmaceutical
  • vasodilator agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Adehl is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Adehl is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Adehl, based on the data on this page

What is Adehl?

Colforsin daropate hydrochloride is the hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.

What is the CAS number of Adehl?

The CAS registry number of Adehl is 138605-00-2.

What is the molecular formula and weight of Adehl?

The molecular formula of Adehl is C27H44ClNO8 and its molar mass is 546.10 g/mol.

What is Adehl used for?

Known uses and roles of Adehl include cardiovascular drugs in pharmaceuticals, cooling agents in flavors and fragrances, adenylate cyclase agonist, agonist, antihypertensive agent and 4 more.

Is Adehl hazardous?

Adehl carries the GHS signal word "Danger". Main hazards: fatal if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Adehl?

Adehl is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Adehl?

CompoundList lists 1 supplier of Adehl in United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Adehl?

Suppliers quote Adehl on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Adehl

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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