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Oncology and immunology drugs

Alectinib

Also known as CH 5424802, 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile, AF 802

CAS 1256580-46-7Formula C30H34N4O2Molar mass 482.63 g/molEC 821-541-6
GHS signal word: Warning. Pictograms: Serious health hazard 108 suppliers listed Drug substance
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Alectinib chemical structure, C30H34N4O2, CAS 1256580-46-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1256580-46-7
Formula
C30H34N4O2
Molar mass
482.63 g/mol
EC number
821-541-6
HS code
293499
Category
Oncology and immunology drugs

What is Alectinib?

Plain description, key identifiers and synonyms

Alectinib is an organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydrochloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a nitrile, a member of piperidines, an organic heterotetracyclic compound, a member of morpholines and an aromatic ketone. It is a conjugate base of an alectinib(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
CAS number
1256580-46-7 CAS number cross-checkedOther or deprecated CAS: 1256589-74-8
EC number
821-541-6
Molecular formula
C30H34N4O2
UNII
LIJ4CT1Z3Y
MDL number
MFCD19440988
InChIKey
KDGFLJKFZUIJMX-UHFFFAOYSA-N
InChI
InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
SMILES (canonical and isomeric)
CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C

Synonyms

  • CH 5424802
  • 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
  • AF 802
  • 9-Ethyl-6,6-Dimethyl-8-[4-(Morpholin-4-Yl)piperidin-1-Yl]-11-Oxo-6,11-Dihydro-5h-Benzo[b]carbazole-3-Carbonitrile
  • 5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-
  • 9-Ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-5H,6H,11H-benzo[b]carbazole-3-carbonitrile
  • 5H-Benzo(b)carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-(4-(4-morpholinyl)-1-piperidinyl)-11-oxo-
  • alectinibum
  • 9-ethyl-6,6-dimethyl-8-(4-(morpholin-4-yl)piperidin-1-yl)-11-oxo-5H,6H,11H-benzo(b)carbazole-3-carbonitrile
  • 9-Ethyl-6,6-dimethyl-8-(4-(morpholin-4-yl)piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo(b)carbazole-3-carbonitrile
  • 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo(b)carbazole-3-carbonitrile
  • ALK Inhibitor RO5424802
  • Alecensa
  • Alectinib (CH5424802)
  • 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
  • 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
  • 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzocarbazole-3-carbonitrile, Alectinib
  • EMH
  • Alectinib (Standard)
  • Alectinib (USAN/INN)
  • CH5424802(Alectinib)
  • ch 5424802, Alectinib
  • CH5424802(Alectinib)?
  • CH-5424802 HCl
  • Sdccgsbi-0654466.p001
Show all 30 synonyms
  • 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-
  • RG-7853,CH5424802
  • Alectinibch-5424802ch5424802ct-ch542
  • CH5424802,CAS:1256580-46-7
  • 9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
482.63 g/molcalc.
Exact mass
482.2682 Dacalc.
LogP (octanol/water)
4.77calc.
Topological polar surface area
72.36 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
3calc.
Heavy atoms
36calc.
Rings
6calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.47calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1c2ccc(N3CCC(N4CCOCC4)CC3)cc2Cc2[nH]c3ccccc3c21

O=C1c2ccc(N3CCC(N4CCOCC4)CC3)cc2Cc2[nH]c3ccccc3c21

6 rings, 30 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H341Suspected of causing genetic defects.
  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (7)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Alectinib suppliers

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All 108 suppliers
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Where suppliers are based

108 suppliers in 16 countries

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Alectinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Tyrosine Kinase Inhibitors

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Alectinib is a Kinase Inhibitor. The mechanism of action of alectinib is as a Kinase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Alectinib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Alectinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Alectinib, based on the data on this page

What is Alectinib?

Alectinib is an organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively.

What is the CAS number of Alectinib?

The CAS registry number of Alectinib is 1256580-46-7. Other or deprecated CAS numbers: 1256589-74-8.

What is the molecular formula and weight of Alectinib?

The molecular formula of Alectinib is C30H34N4O2 and its molar mass is 482.63 g/mol.

What is Alectinib used for?

Known uses and roles of Alectinib include anticancer drugs in pharmaceuticals, antineoplastic agent, enzyme inhibitor, pharmaceutical, protein kinase inhibitor and 2 more.

Is Alectinib hazardous?

Alectinib carries the GHS signal word "Warning". Main hazards: suspected of causing genetic defects, suspected of damaging fertility or the unborn child, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Alectinib?

Alectinib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Alectinib?

CompoundList lists 108 suppliers of Alectinib in China, United States, India, Germany and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Alectinib in India?

8 suppliers in India list Alectinib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Alectinib?

Suppliers quote Alectinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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