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Other active pharmaceutical ingredients

Allantoin

Also known as 5-Ureidohydantoin, Glyoxyldiureide, Cordianine

CAS 97-59-6Formula C4H6N4O3Molar mass 158.12 g/molEC 202-592-8
GHS signal word: Warning. Pictograms: Harmful or irritant 213 suppliers listed Drug substance
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Allantoin chemical structure, C4H6N4O3, CAS 97-59-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from aqueous methanol
Melting point
239 °C
Solubility
Water: 0.57% (25 °C), ethanol (96%): 0.04% (25 °C), eth/water (1/1): 0.35% (25 °C), prop…
HS code
293329
Category
Other active pharmaceutical ingredients
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Allantoin?

Plain description, key identifiers and synonyms

Allantoin is an imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen. It has a role as a vulnerary, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a human metabolite. It is an imidazolidine-2,4-dione and a member of ureas. It is functionally related to a hydantoin. It is a tautomer of a 1-(5-hydroxy-2-oxo-2,3-dihydroimidazol-4-yl)urea.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2,5-dioxoimidazolidin-4-yl)urea
CAS number
97-59-6 CAS number cross-checkedOther or deprecated CAS: 5377-33-3
EC number
202-592-8
Molecular formula
C4H6N4O3
UNII
344S277G0Z
MDL number
MFCD00005260
INCI name
ALLANTOIN
InChIKey
POJWUDADGALRAB-UHFFFAOYSA-N
InChI
InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11)
SMILES (canonical and isomeric)
C1(C(=O)NC(=O)N1)NC(=O)N

Synonyms

  • 5-Ureidohydantoin
  • Glyoxyldiureide
  • Cordianine
  • Glyoxyldiureid
  • Allantol
  • Sebical
  • Alantan
  • AVC/Dienestrolcream
  • Psoralon
  • Septalan
  • Urea, (2,5-dioxo-4-imidazolidinyl)-
  • (2,5-Dioxo-4-imidazolidinyl)urea
  • (2,5-dioxoimidazolidin-4-yl)urea
  • Cutemol emollient
  • Uniderm A
  • DL-Allantoin
  • Alwextin
  • N-(2,5-Dioxo-4-imidazolidinyl)urea
  • 2,5-Dioxo-4-imidazolidinyl-urea
  • Allantoin Cream
  • 4-ureido-2,5-Imidazolidinedione
  • Idelalisib metabolite m1a
  • Kenaf wet wipe
  • Scar Care
  • BL Vital
Show all 39 synonyms
  • BL Vital Skin
  • 5-Ureido-2,4-imidazolidindione
  • Sd 101
  • HerpecinL
  • Jilgyungyi
  • Moisturizing
  • Scarderm
  • Teevodar
  • Purple
  • DeFlame
  • Aluroderm Scar
  • Mulberry Serum
  • Mulberry Toner
  • Chamois Glide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from aqueous methanolexp.
Odour
Odorlessexp.
Taste
Tastelessexp.
Melting point
239 °Cexp.
Solubility
Water: 0.57% (25 °C), ethanol (96%): 0.04% (25 °C), eth/water (1/1): 0.35% (25 °C), propylene glycol/water (1/1): 0.40% (25 °C), glycerol/water (1/1): 0.60% (25 °C)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
158.12 g/molcalc.
Exact mass
158.044 Dacalc.
LogP (octanol/water)
-2.18calc.
Topological polar surface area
113.3 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
11calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CNC(=O)N1

O=C1CNC(=O)N1

1 ring, 7 atoms, the Hydantoin ring system.

705 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Allantoin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 213 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

213 suppliers in 34 countries

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Allantoin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Subpart B: Section 310.545: Drug products containing certain active ingredients offered over-thecounter (OTC) for certain uses. Ingredients-Approved as of May 7, 1991: Allantoin (wound healing claims only).

Subpart B: Section 347.10 Skin protectant active ingredients. The active ingredients of the product consist of any of the following, within the concentration specified for each ingredient: (a) Allantoin, 0.5 to 2 percent.

Allantoin is listed on the FDA OTC Ingredient List as used for or having reviews pending for use as a wound healing agent, skin protectant and external analgesic, a dandruff/seborrheic dermatitis/psoriasis product, a grower for hair loss, a corn/callus remover, and a sunscreen ingredient.

Consumer uses: Other.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name ALLANTOIN(skin conditioning, skin protecting, soothing)

Pharmacological actions

  • Dermatologic Agents

Roles

  • Escherichia coli metabolite
  • Saccharomyces cerevisiae metabolite
  • animal metabolite
  • bacterial metabolite
  • eukaryotic metabolite
  • fungal metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • pharmaceutical
  • prokaryotic metabolite
  • vulnerary

Functional uses

  • Fragrance
  • Humectant
  • Softener and conditioner

Cosmetic functions

  • Skin conditioning
  • Skin protecting
  • Soothing

How it is made

Produced by oxidation of uric acid. Also present in tobacco seeds, sugar beets, wheat sprouts.

Various heterocyclic compounds can be obtained by coupling polynucleophiles with glyoxylic acid: ... with urea and an acid catalyst, allantoin is obtained in 60% yield.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Allantoin is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Allantoin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Allantoin, based on the data on this page

What is Allantoin?

Allantoin is an imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen. It has a role as a vulnerary, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a human metabolite. It is an imidazolidine-2,4-dione and a member of ureas.

What is the CAS number of Allantoin?

The CAS registry number of Allantoin is 97-59-6. Other or deprecated CAS numbers: 5377-33-3.

What is the molecular formula and weight of Allantoin?

The molecular formula of Allantoin is C4H6N4O3 and its molar mass is 158.12 g/mol.

What is Allantoin used for?

Subpart B: Section 310.545: Drug products containing certain active ingredients offered over-thecounter (OTC) for certain uses. Ingredients-Approved as of May 7, 1991: Allantoin (wound healing claims only). Subpart B: Section 347.10 Skin protectant active ingredients.

Is Allantoin hazardous?

Allantoin carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Allantoin?

Allantoin is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Allantoin?

CompoundList lists 213 suppliers of Allantoin in China, United States, India, Germany and 30 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Allantoin in India?

18 suppliers in India list Allantoin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Allantoin?

Suppliers quote Allantoin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Allantoin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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