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Cardiovascular and metabolic drugs

Amiloride

Also known as Amipramidin, Guanamprazin, Amilorida

CAS 2609-46-3Formula C6H8ClN7OMolar mass 229.63 g/molEC 220-024-7
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe), Harmful or irritant 51 suppliers listed Drug substance
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Amiloride chemical structure, C6H8ClN7O, CAS 2609-46-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2609-46-3
Formula
C6H8ClN7O
Molar mass
229.63 g/mol
EC number
220-024-7
HS code
293399
Category
Cardiovascular and metabolic drugs

What is Amiloride?

Plain description, key identifiers and synonyms

Amiloride is a member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid. It has a role as a diuretic and a sodium channel blocker. It is a member of guanidines, an aromatic amine, an organochlorine compound and a member of pyrazines. It is a conjugate base of an amiloride(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
CAS number
2609-46-3 CAS number cross-checkedOther or deprecated CAS: 137053-86-2, 2016-88-8
EC numbers
220-024-7, 926-801-3
Molecular formula
C6H8ClN7O
UNII
7DZO8EB0Z3
InChIKey
XSDQTOBWRPYKKA-UHFFFAOYSA-N
InChI
InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
SMILES (canonical and isomeric)
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N

Synonyms

  • Amipramidin
  • Guanamprazin
  • Amilorida
  • Amipramizid
  • 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
  • Amiloridum
  • Midamor
  • Amiclaran
  • N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
  • 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
  • Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
  • Trom, Amiduret
  • Guanamprazine
  • N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
  • Amiloride (INN)
  • 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
  • Amiloride hydrochloride hydrate
  • N-amidino-3,5-diamino-6-chloro-2-pyrazinecarboxamide
  • C6H8ClN7O
  • Amiclaran (TN)
  • (3,5-diamino-6-chloropyrazin-2-yl)-N-(???methyl)carboxamide
  • AmilorideHCl
  • 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide, hydrochloride
  • Amikal (Hydrochloride dihydrate)
  • Midamor (Hydrochloride dihydrate)
Show all 28 synonyms
  • MK-870 (Hydrochloride dihydrate)
  • Tocris-0890
  • 1f5l

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
229.63 g/molcalc.
Exact mass
229.0479 Dacalc.
LogP (octanol/water)
-1.29calc.
Topological polar surface area
159.3 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cnccn1

c1cnccn1

1 ring, 6 atoms, the Pyrazine ring system.

6,118 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H300Fatal if swallowed.
  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H319Causes serious eye irritation.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (18)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Amiloride suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 51 suppliers
30 of 30 offers
  • Saga Laboratory
    India, Ahmedabad ManufacturerUnclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
    View
  • Saga Laboratories
    India, Ahmedabad ManufacturerUnclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
    View
  • Sinco Pharmachem
    Unclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
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  • Chemcopia
    India ManufacturerUnclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
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  • Enomark Pharma
    India ManufacturerUnclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
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  • Essential Pharma Group
    United Kingdom ManufacturerUnclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
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  • Pro Test
    Poland, Warszawa ManufacturerUnclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
    View
  • AN Pharma
    Unclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
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  • 001Chemical
    China, HangzhouUnclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
    View
  • 10X Chem
    United States, San DiegoUnclaimed profile
    AmilorideGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

51 suppliers in 13 countries

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Amiloride price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Acid Sensing Ion Channel Blockers
  • Diuretics
  • Epithelial Sodium Channel Blockers

Roles

  • antihypertensive agent
  • biophysical role
  • cardiovascular drug
  • diuretic
  • immunomodulator
  • immunosuppressive agent
  • membrane transport modulator
  • pharmaceutical
  • sodium channel blocker
  • sodium channel modulator

Functional uses

  • Pharmaceutical

Pharmacology

Amiloride is a Potassium-sparing Diuretic. The physiologic effect of amiloride is by means of Decreased Renal K+ Excretion and Increased Diuresis.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Amiloride is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Amiloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Amiloride, based on the data on this page

What is Amiloride?

Amiloride is a member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid. It has a role as a diuretic and a sodium channel blocker.

What is the CAS number of Amiloride?

The CAS registry number of Amiloride is 2609-46-3. Other or deprecated CAS numbers: 137053-86-2, 2016-88-8.

What is the molecular formula and weight of Amiloride?

The molecular formula of Amiloride is C6H8ClN7O and its molar mass is 229.63 g/mol.

What is Amiloride used for?

Use classes: Pharmaceuticals.

Is Amiloride hazardous?

Amiloride carries the GHS signal word "Danger". Main hazards: fatal if swallowed, harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Amiloride?

Amiloride is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Amiloride?

CompoundList lists 51 suppliers of Amiloride in China, United States, United Kingdom, India and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Amiloride in India?

4 suppliers in India list Amiloride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Amiloride?

Suppliers quote Amiloride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Amiloride

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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