Amitriptyline safety data
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
GHS classification
Pictograms, signal word and hazard classes of the GHS classification
Hazard classes and categories
- Acute Tox. 3 (oral) + Acute Tox. 3 (dermal) + Acute Tox. 3 (inhalation)
- Acute Tox. 3 (oral)
- Acute Tox. 4 (oral)
- Acute Tox. 3 (dermal)
- Eye Dam. 1
- Acute Tox. 3 (inhalation)
- Repr. 2
- Aquatic Chronic 1
Hazard statements
H codes grouped by type. Percentages show the share of classification notifications that report the statement
Health hazards
- H301 + H311 + H331Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.
- H301Toxic if swallowed.
- H302Harmful if swallowed.
- H311Toxic in contact with skin.
- H318Causes serious eye damage.
- H331Toxic if inhaled.
- H361Suspected of damaging fertility or the unborn child.
Environmental hazards
- H410Very toxic to aquatic life with long lasting effects.
Precautionary statements
P codes for prevention, response, storage and disposal
Prevention
- P203Obtain, read and follow all safety instructions before use.
- P261Avoid breathing dust, fume, gas, mist, vapours or spray.
- P262Do not get in eyes, on skin, or on clothing.
- P264Wash skin thoroughly after handling.
- P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
- P270Do not eat, drink or smoke when using this product.
- P271Use only outdoors or in a well-ventilated area.
- P273Avoid release to the environment.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
Response
- P301 + P316If swallowed: Get emergency medical help immediately.
- P301 + P317If swallowed: Get medical help.
- P302 + P352If on skin: Wash with plenty of water.
- P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
- P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P316Get emergency medical help immediately.
- P317Get medical help.
- P318If exposed or concerned, get medical advice.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
- P391Collect spillage.
Storage
- P403 + P233Store in a well-ventilated place. Keep container tightly closed.
- P405Store locked up.
Disposal
- P501Dispose of contents and container in accordance with local regulations.
Handling, storage and disposal
Summaries only, follow the supplier SDS for your grade
Safe handling
Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). /Amitriptyline hydrochloride/ Skin protection: Handle with gloves. /Amitriptyline hydrochloride/
Storage
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C. Keep in a dry place. /Amitriptyline hydrochloride/ Amitriptyline hydrochloride tablets should be stored in well-closed containers at a temperature preferably between 15-30 °C, exposure to temperatures exceeding 30 °C should be avoided.
Disposal
SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.
Exposure limits and toxicity
Occupational exposure limits and toxicity data
Symptoms of overdose/poisoning may include the following: hypothermia, respiratory depression, seizures, abnormal tendon reflexes, disorientation, agitation, myoclonic jerks, coma, pyramidal signs, arrhythmias, bundle branch block, cardiac arrest, hypotension, circulatory collapse, mydriasis, blurred vision, tachycardia, vasodilation, urinary retention, decreased gastrointestinal motility, decreased bronchial secretions, and dry mucous membranes and skin.
Supplier safety data sheets
SDS documents uploaded by suppliers who list this chemical
No supplier has uploaded an SDS for Amitriptyline yet. Suppliers usually send one with their quote. Request quotes
Safety questions
Quick answers about handling Amitriptyline safely
Is Amitriptyline hazardous?
Which GHS pictograms apply to Amitriptyline?
How should Amitriptyline be stored?
Where can I get the SDS for Amitriptyline?
GHS classification summary, not an SDS. Always check the supplier's SDS. Last updated 7 Oct 2026. Report an error