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Cardiovascular and metabolic drugs

Amrinone

Also known as inamrinone, Cartonic, Amcoral

CAS 60719-84-8Formula C10H9N3OMolar mass 187.20 g/molEC 262-390-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 57 suppliers listed
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Amrinone chemical structure, C10H9N3O, CAS 60719-84-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
60719-84-8
Formula
C10H9N3O
Molar mass
187.20 g/mol
EC number
262-390-0
HS code
293339
Category
Cardiovascular and metabolic drugs

What is Amrinone?

Plain description, key identifiers and synonyms

Amrinone is a 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure. It has a role as a cardiovascular drug and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-amino-5-pyridin-4-yl-1H-pyridin-2-one
CAS number
60719-84-8 CAS number cross-checked
EC number
262-390-0
Molecular formula
C10H9N3O
UNII
JUT23379TN
MDL number
MFCD00083228
InChIKey
RNLQIBCLLYYYFJ-UHFFFAOYSA-N
InChI
InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
SMILES (canonical and isomeric)
C1=CN=CC=C1C2=CNC(=O)C(=C2)N

Synonyms

  • inamrinone
  • Cartonic
  • Amcoral
  • Vesistol
  • Amrinona
  • Amrinonum
  • WIN 40680
  • [3,4'-Bipyridin]-6(1H)-one, 5-amino-
  • 5-Amino(3,4'-bipyridin)-6(1H)-one
  • (3,4'-Bipyridin)-6(1H)-one, 5-amino-
  • 3-amino-5-(pyridin-4-yl)pyridin-2-ol
  • 5-Amino[3,4'-bipyridin]-6(1H)-one
  • Amrinon
  • 3-amino-5-(pyridin-4-yl)-1,2-dihydropyridin-2-one
  • 5-Amino-(3,4'-bipyridine)-6(1H)-one
  • Wincoram
  • Inocor
  • Cordemcura
  • 5-Amino-[3,4'-bipyridin]-6(1H)-one
  • 3-amino-5-pyridin-4-yl-1H-pyridin-2-one
  • 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone
  • 5-Amino-(3,4'-bipyridin)-6(1H)-one
  • AWD 08-250
  • 5-amino-3,4'-bipyridin-6(1H)-one
  • 3-Amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone
Show all 31 synonyms
  • Inamrinone (USP)
  • Amcoral (TN)
  • Amrinone (JAN/INN)
  • Inamrinone,
  • Amrinone (Standard)
  • 3-amino-5-pyridin-4-ylpyridin-2-ol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
187.20 g/molcalc.
Exact mass
187.0746 Dacalc.
LogP (octanol/water)
1.02calc.
Topological polar surface area
71.77 ร…ยฒcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
14calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccc(-c2ccncc2)c[nH]1

O=c1ccc(-c2ccncc2)c[nH]1

2 rings, 13 atoms, the [3,4'-Bipyridin]-6(1H)-one ring system.

38 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Amrinone suppliers

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All 57 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

57 suppliers in 13 countries

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Amrinone price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Calcium Channel Blockers
  • Cardiotonic Agents
  • Phosphodiesterase 3 Inhibitors
  • Vasodilator Agents

Roles

  • cardiovascular drug
  • enzyme inhibitor
  • pharmaceutical

Pharmacology

Inamrinone is a synthetic bipyridine phosphodiesterase inhibitor with inotropic and vasodilator properties. Inamrinone inhibits type III phosphodiesterase, which is abundant in cardiac and vascular tissues, thereby preventing the degradation of cyclic adenosine monophosphate (cAMP) and increasing intracellular concentrations of this secondary messenger. Elevated levels of cAMP increase the contractile force of the cardiac muscle and produce positive inotropic effects. Although the mechanism of action is not fully understood, inamrinone causes smooth muscle relaxation, resulting in peripheral vasodilation (reduced afterload) and a decreased pulmonary vascular resistance (reduced preload).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Amrinone is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structureโ€ฆ

World exports in 2024
$9.16B
โˆ’17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Amrinone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Amrinone, based on the data on this page

What is Amrinone?

Amrinone is a 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.

What is the CAS number of Amrinone?

The CAS registry number of Amrinone is 60719-84-8.

What is the molecular formula and weight of Amrinone?

The molecular formula of Amrinone is C10H9N3O and its molar mass is 187.20 g/mol.

What is Amrinone used for?

Use classes: Pharmaceuticals.

Is Amrinone hazardous?

Amrinone carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Amrinone?

Amrinone is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in theโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Amrinone?

CompoundList lists 57 suppliers of Amrinone in China, United States, United Kingdom, Hong Kong and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Amrinone in India?

1 supplier in India list Amrinone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Amrinone?

Suppliers quote Amrinone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Amrinone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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