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Heterocyclic building blocks

Antazoline

Also known as Phenazoline, Antihistal, Antastan

CAS 91-75-8Formula C17H19N3Molar mass 265.36 g/molEC 202-094-0
GHS signal word: Warning. Pictograms: Harmful or irritant 18 suppliers listed
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Antazoline chemical structure, C17H19N3, CAS 91-75-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White, crystalline powder
Melting point
120 to 122
Solubility
Mol wt 301.82. Bitter crystals producing temporary numbness of the tongue. mp 237-241 °C…
HS code
293329
Category
Heterocyclic building blocks
Illustrative photo, off-white crystalline powder in an HDPE jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Antazoline?

Plain description, key identifiers and synonyms

Antazoline is a member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug. It has a role as a xenobiotic, a H1-receptor antagonist and a cholinergic antagonist. It is an aromatic amine, a tertiary amino compound and a member of imidazolines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
CAS number
91-75-8 CAS number cross-checked
EC number
202-094-0
Molecular formula
C17H19N3
UNII
DHA8014SS1
InChIKey
REYFJDPCWQRWAA-UHFFFAOYSA-N
InChI
InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)
SMILES (canonical and isomeric)
C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3

Synonyms

  • Phenazoline
  • Antihistal
  • Antastan
  • Antasten
  • Azalone
  • Antistine
  • Histostab
  • Imidamine
  • Antazolin
  • Antazolina
  • Antazolinum
  • Ben-A-hist
  • N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
  • 2-(N-Phenyl-N-benzylaminomethyl)imidazoline
  • Atazoline
  • 2-Phenyl-benzyl-amino-methylimidazolin
  • 2-(N-Benzylanilinomethyl)-2-imidazoline
  • 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine
  • 1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-
  • Antazolinum (Latin)
  • Antaz sulf
  • Antistin
  • Phenazolin
  • N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline
  • Antazoline (INN)
Show all 33 synonyms
  • Imidamin
  • Analergine
  • N-Benzyl-N-[(4,5-dihydro-1H-imidazol-2-yl)methyl]aniline
  • N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline hydrochloride
  • 2-[(N-Benzylanilino)methyl]-2-imidazoline
  • N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline
  • 2-Imidazoline, 2-((N-benzylanilino)methyl)-
  • 2-Imidazoline, 2-[(N-benzylanilino)methyl]-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White, crystalline powderexp.
Odour
Odorlessexp.
Taste
Bitterexp.
Melting point
120 to 122exp.
Solubility
Mol wt 301.82. Bitter crystals producing temporary numbness of the tongue. mp 237-241 °C. UV max: 242 nm (E 1% 1cm = 495 to 515), min 222 nm. One gram dissolves in 40 ml water, in 25 ml alc.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
265.36 g/molcalc.
Exact mass
265.1579 Dacalc.
LogP (octanol/water)
2.69calc.
Topological polar surface area
27.63 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
5calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.24calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1

c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1

3 rings, 20 atoms. This chemical is the scaffold itself.

11 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (20)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Antazoline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 18 suppliers
18 of 18 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

18 suppliers in 6 countries

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Antazoline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antihistaminic.

Therapeutic category (veterinary): Antihistaminic.

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Allergic Agents
  • Histamine H1 Antagonists

Roles

  • H1-receptor antagonist
  • antagonist
  • cholinergic antagonist
  • cholinergic drug
  • histamine antagonist
  • histaminergic drug
  • nasal decongestant
  • neurotransmitter agent
  • pharmaceutical
  • xenobiotic

Pharmacology

Antazoline is an ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline antagonizes histamine H1 receptor and prevents the typical allergic symptoms caused by histamine activities on capillaries, skin, mucous membranes, and gastrointestinal and bronchial smooth muscles. These histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Antazoline is used to provide symptomatic relieve of allergic symptoms.

How it is made

Prepared by the condensation of benzylaniline with 2-(chloromethyl)imidazoline.

Synthesis of Ethylenediamines. Three different methods of synthesizing ethylenediamines are widely used: 1. Reaction of tertiary chloroethylamines with secondary amines in the presence of a base, e.g., NaH, NaNH2, NaOC2H5, or KOH. 2. Alkylation of secondary amines, such as N-(2-dimethylaminoethyl)aniline with benzyl chlorides in the presence of a strong base. 3. Reaction of reactive heterocyclic halogen compounds, such as 2-bromopyridine with secondary amines, such as N-(2-dimethylaminoethyl)-aniline, also in the presence of a strong base. (Ethylenediamies)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Antazoline is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Antazoline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Antazoline, based on the data on this page

What is Antazoline?

Antazoline is a member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug. It has a role as a xenobiotic, a H1-receptor antagonist and a cholinergic antagonist.

What is the CAS number of Antazoline?

The CAS registry number of Antazoline is 91-75-8.

What is the molecular formula and weight of Antazoline?

The molecular formula of Antazoline is C17H19N3 and its molar mass is 265.36 g/mol.

What is Antazoline used for?

Therapeutic category: Antihistaminic. Therapeutic category (veterinary): Antihistaminic. Veterinary medication:. Use classes: Pharmaceuticals.

Is Antazoline hazardous?

Antazoline carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Antazoline?

Antazoline is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Antazoline?

CompoundList lists 18 suppliers of Antazoline in United States, China, India, Australia and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Antazoline in India?

2 suppliers in India list Antazoline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Antazoline?

Suppliers quote Antazoline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Antazoline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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