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Impurities and reference standards

(±)-Apremilast

Also known as Acetamide, N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-, Apremilast, (+-)-, Apremilast (+-)-form

CAS 253168-86-4Formula C22H24N2O7SMolar mass 460.51 g/mol
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(±)-Apremilast chemical structure, C22H24N2O7S, CAS 253168-86-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
253168-86-4
Formula
C22H24N2O7S
Molar mass
460.51 g/mol
HS code
293090
Category
Impurities and reference standards

What is (±)-Apremilast?

Plain description, key identifiers and synonyms

(±)-Apremilast is a chemical substance with the molecular formula C22H24N2O7S and a molar mass of 460.51 g/mol. Its CAS registry number is 253168-86-4. The IUPAC name is N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
CAS number
253168-86-4
Molecular formula
C22H24N2O7S
UNII
N5UK68MGDZ
InChIKey
IMOZEMNVLZVGJZ-UHFFFAOYSA-N
InChI
InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)
SMILES (canonical and isomeric)
CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC

Synonyms

  • Acetamide, N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-
  • Apremilast, (+-)-
  • Apremilast (+-)-form
  • Apremilast, (+/-)-
  • N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
  • N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
  • Apremilast (+/-)-form
  • (+/-)-apremilast
  • rac-Apremilast
  • N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
  • rac-4'-O-Ethyl-3'-O-methyl Apremilast
  • (Rac)-Apremilast
  • Apremilast enantiomer
  • N-{2-[(1R)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
  • 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
  • Apremilast Impurity 82, Rac-Apremilast
  • (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
  • 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetamidoisoindoline-1,3-dione
  • 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1.3-dione
  • 2-[1-(3-Ethoxy4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione
  • N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindolin-4-yl]acetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
460.51 g/molcalc.
Exact mass
460.1304 Dacalc.
LogP (octanol/water)
2.43calc.
Topological polar surface area
119.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
8calc.
Heavy atoms
32calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1c2ccccc2C(=O)N1Cc1ccccc1

O=C1c2ccccc2C(=O)N1Cc1ccccc1

3 rings, 18 atoms, the Benzylphthalimide ring system.

251 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(±)-Apremilast suppliers

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Where suppliers are based

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(±)-Apremilast price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (±)-Apremilast is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for (±)-Apremilast is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (±)-Apremilast, based on the data on this page

What is (±)-Apremilast?

(±)-Apremilast is a chemical substance with the molecular formula C22H24N2O7S and a molar mass of 460.51 g/mol. Its CAS registry number is 253168-86-4. The IUPAC name is N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide.

What is the CAS number of (±)-Apremilast?

The CAS registry number of (±)-Apremilast is 253168-86-4.

What is the molecular formula and weight of (±)-Apremilast?

The molecular formula of (±)-Apremilast is C22H24N2O7S and its molar mass is 460.51 g/mol.

Is (±)-Apremilast hazardous?

No GHS hazard classification for (±)-Apremilast is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (±)-Apremilast?

(±)-Apremilast is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (±)-Apremilast?

CompoundList lists 1 supplier of (±)-Apremilast in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (±)-Apremilast?

Suppliers quote (±)-Apremilast on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (±)-Apremilast

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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