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Analgesics and anti-inflammatories

Apremilast

Also known as Otezla, CC 10004, apremilastum

CAS 608141-41-9Formula C22H24N2O7SMolar mass 460.51 g/molEC 807-237-6
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 138 suppliers listed Drug substance
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Apremilast chemical structure, C22H24N2O7S, CAS 608141-41-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
608141-41-9
Formula
C22H24N2O7S
Molar mass
460.51 g/mol
EC number
807-237-6
HS code
293090
Category
Analgesics and anti-inflammatories

What is Apremilast?

Plain description, key identifiers and synonyms

Apremilast is a member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis. It has a role as a non-steroidal anti-inflammatory drug and a phosphodiesterase IV inhibitor. It is a N-acetylarylamine, an aromatic ether, a sulfone and a member of phthalimides.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
CAS number
608141-41-9 CAS number cross-checked
EC numbers
807-237-6, 944-453-0
Molecular formula
C22H24N2O7S
UNII
UP7QBP99PN
MDL number
MFCD18782607
InChIKey
IMOZEMNVLZVGJZ-QGZVFWFLSA-N
InChI
InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
Canonical SMILES
CCOc1cc(C(CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC
Isomeric SMILES
CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC

Synonyms

  • Otezla
  • CC 10004
  • apremilastum
  • N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
  • N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
  • Acetamide, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
  • Acetamide, N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-
  • N-(2-((1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide
  • N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide
  • (+)-N-(2-((1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide
  • (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
  • Apremilast (CC-10004)
  • (S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
  • N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
  • (+)-N-(2-((1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxo- 2,3-dihydro-1H-isoindol-4-yl)acetamide
  • Apremilast?
  • (S)-Apremilast
  • Apremilast- Bio-X
  • Otezla (TN)
  • Apremilast (Standard)
  • Apremilast (JAN/USAN)
  • Apremilast Reference Standard
  • Apremilast - Bio-X trade mark
  • cas:608141-41-9, Apremilast
  • (S)-4-Acetylamino-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]isoindoline-1,3-dione
Show all 26 synonyms
  • (S)-N-{2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
460.51 g/molcalc.
Exact mass
460.1304 Dacalc.
LogP (octanol/water)
2.43calc.
Topological polar surface area
119.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
8calc.
Heavy atoms
32calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1c2ccccc2C(=O)N1Cc1ccccc1

O=C1c2ccccc2C(=O)N1Cc1ccccc1

3 rings, 18 atoms, the Benzylphthalimide ring system.

251 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Apremilast suppliers

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All 138 suppliers
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Where suppliers are based

138 suppliers in 18 countries

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Apremilast price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Anti-Inflammatory Agents, Non-Steroidal, Phosphodiesterase Inhibitors.

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal
  • Phosphodiesterase 4 Inhibitors

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • anti-ulcer drug
  • antimicrobial agent
  • antipsoriatic
  • antirheumatic drug
  • antiviral agent
  • dermatologic drug
  • enzyme inhibitor
  • gout suppressant
  • non-steroidal anti-inflammatory drug
  • ophthalmology drug
  • pharmaceutical
  • phosphodiesterase IV inhibitor

Pharmacology

Apremilast is a Phosphodiesterase 4 Inhibitor. The mechanism of action of apremilast is as a Phosphodiesterase 4 Inhibitor.

How it is made

Preparation (stereochemistry unspecified): G. W. Muller, H.-W. Man, United States of America patent 6020358 (2000 to Celgene). Preparation of S-isomer: P. H. Schafer et al., World Intellectual Property Organization patent 03080049, eidem, United States of America patent 7427638 (2003, 2008 both to Celgene).

The manufacturing process consists of three main steps: i) blending and lubrication process, ii) compression process and iii) coating process. The process is considered to be a standard manufacturing process.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Apremilast is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Apremilast is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Apremilast, based on the data on this page

What is Apremilast?

Apremilast is a member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.

What is the CAS number of Apremilast?

The CAS registry number of Apremilast is 608141-41-9.

What is the molecular formula and weight of Apremilast?

The molecular formula of Apremilast is C22H24N2O7S and its molar mass is 460.51 g/mol.

What is Apremilast used for?

Anti-Inflammatory Agents, Non-Steroidal, Phosphodiesterase Inhibitors.

Is Apremilast hazardous?

Apremilast carries the GHS signal word "Danger". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Apremilast?

Apremilast is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Apremilast?

CompoundList lists 138 suppliers of Apremilast in China, United States, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Apremilast in India?

25 suppliers in India list Apremilast on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Apremilast?

Suppliers quote Apremilast on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Apremilast

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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