Artenimol
Also known as Cotexin, Alaxin, Cotecxin
Key facts
What buyers check first
- CAS number
- 71939-50-9
- Formula
- C15H24O5
- Molar mass
- 284.35 g/mol
- EC number
- 615-698-8
- HS code
- 293299
- Category
- Initiators, curing agents and crosslinkers
What is Artenimol?
Plain description, key identifiers and synonyms
Artenimol is an artemisinin derivative.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- (1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
- CAS number
- 71939-50-9 CAS number cross-checkedOther or deprecated CAS: 81496-82-4
- EC number
- 615-698-8
- Molecular formula
- C15H24O5
- UNII
- 6A9O50735X
- MDL number
- MFCD00274495
- InChIKey
- BJDCWCLMFKKGEE-ISOSDAIHSA-N
- InChI
- InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
- Canonical SMILES
- CC1CCC2C(C)C(O)OC3OC4(C)CCC1C32OO4
- Isomeric SMILES
- C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)O)C
Synonyms
- Cotexin
- Alaxin
- Cotecxin
- Dihydroartemisinine
- Dihydroqinghaosu
- Salaxin
- Santecxin
- Dynamax
- Di-hydroqinghaosu
- Artenimolum
- beta-Dihydroartemisinin
- (1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
- Dihydroquinghaosu
- Eurartesim component dihydroartemisinin
- (3r,5as,6r,8as,9r,10s,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j][1,2]benzodioxepin-10-ol
- quinghaosu, dihydro-
- artemisinin, dihydro-
- (1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo(10.3.1.04,13.08,13)hexadecan-10-ol
- (3r,5as,6r,8as,9r,10s,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)(1,2)benzodioxepin-10-ol
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol
- I2-dihydroartemisinine
- Dihydroartemisinin, beta-
- (1S,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo(10.3.1.04,13.08,13)hexadecan-10-ol
- dihydroquinghaosu, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12alpha,12aR*))-
- (1R,4S,5R,8S,9R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo(10.3.1.04,13.08,13)hexadecan-10-ol
Show all 31 synonymsShow fewer synonyms
- Dihydroartemisinin
- Dihydro Artemisinin
- DHQHS 2
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
- 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
- ?-dihydroartemisinin
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 284.35 g/molcalc.Computed value |
|---|---|
| Exact mass | 284.1624 Dacalc.Computed value |
| LogP (octanol/water) | 2.19calc.Computed value |
| Topological polar surface area | 57.15 Ųcalc.Computed value |
| Hydrogen bond donors | 1calc.Computed value |
| Hydrogen bond acceptors | 5calc.Computed value |
| Rotatable bonds | 0calc.Computed value |
| Heavy atoms | 20calc.Computed value |
| Rings | 5calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 1calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 8calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H242Heating may cause a fire.
- H411Toxic to aquatic life with long lasting effects.
Precautionary statements (13)
- P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P234Keep only in original packaging.
- P235Keep cool.
- P240Ground and bond container and receiving equipment.
- P273Avoid release to the environment.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P370 + P378In case of fire: Use appropriate media to extinguish.
- P391Collect spillage.
- P403Store in a well-ventilated place.
- P410Protect from sunlight.
- P411Store at temperatures not exceeding the specified limit.
- P420Store separately.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidArtenimol suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- China, Chengdu ManufacturerUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
- Price on request
- China, NanjingUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
- United States, Monmouth JunctionUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
- United States, HoustonUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
- Spain, BarcelonaUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
- United States, San DiegoUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
- United States, FriscoUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
- United States, HaywardUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
- China, KowloonUnclaimed profileArtenimolGrade, purity and minimum order on requestPrice on request
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Where suppliers are based
44 suppliers in 11 countries
- United States20
- China12
- Germany2
- United Kingdom2
- Canada1
- Czech Republic1
- and 5 more countries
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Artenimol price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Industries and functions
Pharmacological actions
- Antimalarials
Roles
- antiinfective agent
- antimalarial
- antimicrobial agent
- antimicrobial drug
- antineoplastic agent
- antiparasitic agent
- antiplasmodial drug
- antiprotozoal drug
- pharmaceutical
Pharmacology
Artenimol is an active metabolite of artesunate, with anti-malarial activity, and potential insulin sensitivity-improving, anti-inflammatory, immunomodulating and antineoplastic activities. Upon administration of artenimol and the hydrolysis of its active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells (RBCs), reactive oxygen species (ROS) and carbon-centered radicals form, which damage and kill parasitic organisms. Artenimol may also increase insulin sensitivity and improve insulin resistance.
Read more
In addition, artenimol induces the 26S proteasome-mediated degradation of the androgen receptor (AR), thereby lowering AR expression, which may prevent androgen-responsive cellular proliferation. It also reduces luteinizing hormone LH) and testosterone levels, and may improve polycystic ovary syndrome (PCOS). In addition, artenimol may modulate the immune system and may inhibit tumor cell proliferation through various apoptotic and non-apoptotic pathways.
Regulatory status
Inventories, regulations and trade controls that list this substance
No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Artenimol is traded under.
Heterocyclic compounds with oxygen hetero-atom(s) only, other
- China28.9%
- Switzerland * partner reported12.7%
- Germany7.8%
- United States49.7%
- China11.9%
- India * partner reported3.3%
* Partner reported figures, a lower bound.
The HS code shown for Artenimol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Artenimol, based on the data on this page
What is Artenimol?
What is the CAS number of Artenimol?
What is the molecular formula and weight of Artenimol?
What is Artenimol used for?
Is Artenimol hazardous?
What is the HS code of Artenimol?
Where can I buy Artenimol?
What is the price of Artenimol?
Guides for buyers
Practical guides that help when you source, ship or handle Artenimol
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
- Article, QualityWhat a certificate of analysis should containThe parts of a complete COA, how to read it against your specification, the warning signs of a weak or copied certificate and how to verify results.Read
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