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Antibiotics and anti-infectives

Arterolane

Also known as Glucoamylase, trioxolane, OZ 277

CAS 664338-39-0Formula C22H36N2O4Molar mass 392.54 g/mol
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Arterolane chemical structure, C22H36N2O4, CAS 664338-39-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
664338-39-0
Formula
C22H36N2O4
Molar mass
392.54 g/mol
HS code
293299
Category
Antibiotics and anti-infectives

What is Arterolane?

Plain description, key identifiers and synonyms

Arterolane is an oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine. It has a role as an antimalarial and an antiplasmodial drug. It is a secondary carboxamide, a trioxolane, an oxaspiro compound, a primary amino compound and a member of adamantanes. It is a conjugate base of an arterolane(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

CAS number
664338-39-0 CAS number cross-checked
Molecular formula
C22H36N2O4
UNII
3N1TN351VB
MDL number
MFCD18251543
InChIKey
VXYZBLXGCYNIHP-UHFFFAOYSA-N
InChI
InChI=1S/C22H36N2O4/c1-20(2,23)13-24-19(25)12-14-3-5-21(6-4-14)26-22(28-27-21)17-8-15-7-16(10-17)11-18(22)9-15/h14-18H,3-13,23H2,1-2H3,(H,24,25)
SMILES (canonical and isomeric)
CC(C)(CNC(=O)CC1CCC2(CC1)OC3(C4CC5CC(C4)CC3C5)OO2)N

Synonyms

  • Glucoamylase
  • trioxolane
  • OZ 277
  • arterolano
  • OZ 277, RBx 11160
  • N-(2-amino-2-methylpropyl)-2-{dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1''-cyclohexane]-4''-yl}acetamide
  • arterolanum
  • OZ277 cpd
  • RBx 11160
  • Dispiro(cyclohexane-1,3'-(1,2,4)trioxolane-5',2''-tricyclo(3.3.1.13,7)decane)-4-acetamide, N-(2-amino-2-methylpropyl)-, cis-
  • N-(2-Amino-2-methylpropyl)-2-((1R,3R,4''s,5R,5's,7R)-dispiro[adamantane-2,3'-[1,2,4]trioxolane-5',1''-cyclohexan]-4''-yl)acetamide
  • N-(2-Amino-2-methylpropyl)-2-[(1s,1''s,3''s,4s)-dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1~3,7~]decan]-4-yl]acetamide
  • N-(2-amino-2-methylpropyl)-2-[(1s,4s)-dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1(3,7)]decan]-4-yl]acetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
392.54 g/molcalc.
Exact mass
392.2675 Dacalc.
LogP (octanol/water)
3.25calc.
Topological polar surface area
82.81 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
28calc.
Rings
6calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.96calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCC2(CC1)OOC1(O2)C2CC3CC(C2)CC1C3

C1CCC2(CC1)OOC1(O2)C2CC3CC(C2)CC1C3

6 rings, 19 atoms.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Arterolane suppliers

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Arterolane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antiinfective agent
  • antimalarial
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Arterolane is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Arterolane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Arterolane, based on the data on this page

What is Arterolane?

Arterolane is an oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine.

What is the CAS number of Arterolane?

The CAS registry number of Arterolane is 664338-39-0.

What is the molecular formula and weight of Arterolane?

The molecular formula of Arterolane is C22H36N2O4 and its molar mass is 392.54 g/mol.

What is Arterolane used for?

Known uses and roles of Arterolane include initiators and catalysts in plastics and polymers, curing agents and crosslinkers in plastics and polymers, antiinfective agent, antimalarial, antimicrobial agent and 5 more.

Is Arterolane hazardous?

No GHS hazard classification for Arterolane is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Arterolane?

Arterolane is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Arterolane?

Post a free request on CompoundList and suppliers of Arterolane will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Arterolane?

Suppliers quote Arterolane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Arterolane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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