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Screening compounds

Azd7762

Also known as AZD 7762, Checkpoint kinase inhibitor azd7762, (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide

CAS 860352-01-8Formula C17H19FN4O2SMolar mass 362.43 g/molEC 804-400-3
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant 6 suppliers listed
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Azd7762 chemical structure, C17H19FN4O2S, CAS 860352-01-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
860352-01-8
Formula
C17H19FN4O2S
Molar mass
362.43 g/mol
EC number
804-400-3
HS code
293499
Category
Screening compounds

What is Azd7762?

Plain description, key identifiers and synonyms

AZD7762 is a member of the class of thiophenes that is thiophene substituted by N-[(3S)-piperidin-3-yl]aminocarbonyl, carbamoylamino, and 3-fluorophenyl groups at positions 2, 3 and 5, respectively. It is a potent ATP-competitive checkpoint kinase inhibitor (IC50 = 5 nM for Chk1). It has a role as an antineoplastic agent, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of piperidines, a member of thiophenes, a member of ureas, an aromatic amide and a member of monofluorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide
CAS number
860352-01-8 CAS number cross-checkedOther or deprecated CAS: 1019773-80-8, 1246094-78-9
EC numbers
804-400-3, 806-399-5
Molecular formula
C17H19FN4O2S
UNII
5D822Y3L1H
MDL number
MFCD12406007
InChIKey
IAYGCINLNONXHY-LBPRGKRZSA-N
InChI
InChI=1S/C17H19FN4O2S/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24)/t12-/m0/s1
Canonical SMILES
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)NC1CCCNC1
Isomeric SMILES
C1C[C@@H](CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N

Synonyms

  • AZD 7762
  • Checkpoint kinase inhibitor azd7762
  • (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide
  • 3-(Carbamoylamino)-5-(3-Fluorophenyl)-N-[(3s)-Piperidin-3-Yl]thiophene-2-Carboxamide
  • 860352-01-8 (free base)
  • 5-(3-Fluorophenyl)-N-[(3s)-3-Piperidyl]-3-Ureido-Thiophene-2-Carboxamide
  • 2-Thiophenecarboxamide, 3-((aminocarbonyl)amino)-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-
  • 2-Thiophenecarboxamide, 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-
  • YDJ
  • 3-((Aminocarbonyl)amino)-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide
  • Sdccgsbi-0654382.p001
  • (S)-5-(3-Fluorophenyl)-N-(3-piperidyl)-3-ureidothiophene-2-carboxamide
  • 5-(3-Fluoro-phenyl)-3-ureido-thiophene-2-carboxylic acid (S)-Piperidin-3-ylamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
362.43 g/molcalc.
Exact mass
362.1213 Dacalc.
LogP (octanol/water)
2.53calc.
Topological polar surface area
96.25 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
25calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NC1CCCNC1)c1ccc(-c2ccccc2)s1

O=C(NC1CCCNC1)c1ccc(-c2ccccc2)s1

3 rings, 20 atoms.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H318Causes serious eye damage.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Azd7762 suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 2 countries

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Azd7762 price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • apoptosis inducer
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor

Pharmacology

Checkpoint Kinase Inhibitor AZD7762 is a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Azd7762 is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Azd7762 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Azd7762, based on the data on this page

What is Azd7762?

AZD7762 is a member of the class of thiophenes that is thiophene substituted by N-[(3S)-piperidin-3-yl]aminocarbonyl, carbamoylamino, and 3-fluorophenyl groups at positions 2, 3 and 5, respectively. It is a potent ATP-competitive checkpoint kinase inhibitor (IC50 = 5 nM for Chk1).

What is the CAS number of Azd7762?

The CAS registry number of Azd7762 is 860352-01-8. Other or deprecated CAS numbers: 1019773-80-8, 1246094-78-9.

What is the molecular formula and weight of Azd7762?

The molecular formula of Azd7762 is C17H19FN4O2S and its molar mass is 362.43 g/mol.

What is Azd7762 used for?

Known uses and roles of Azd7762 include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, apoptosis inducer, enzyme inhibitor and 2 more.

Is Azd7762 hazardous?

Azd7762 carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Azd7762?

Azd7762 is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Azd7762?

CompoundList lists 6 suppliers of Azd7762 in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Azd7762?

Suppliers quote Azd7762 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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