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Analgesics and anti-inflammatories

Baicalin

Also known as Baicalein 7-O-glucuronide, Baicalein 7-glucuronide, 7-D-Glucuronic acid-5,6-dihydroxyflavone

CAS 21967-41-9Formula C21H18O11Molar mass 446.36 g/molEC 606-866-1
GHS signal word: Warning. Pictograms: Harmful or irritant 94 suppliers listed
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Baicalin chemical structure, C21H18O11, CAS 21967-41-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
21967-41-9
Formula
C21H18O11
Molar mass
446.36 g/mol
EC number
606-866-1
HS code
293299
Category
Analgesics and anti-inflammatories

What is Baicalin?

Plain description, key identifiers and synonyms

Baicalin is the glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has a role as an antiatherosclerotic agent, an anticoronaviral agent, an EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor, a ferroptosis inhibitor, an antioxidant, an antibacterial agent, a non-steroidal anti-inflammatory drug, an antineoplastic agent, a prodrug, a neuroprotective agent, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, a plant metabolite and a cardioprotective agent. It is a glucosiduronic acid, a dihydroxyflavone, a glycosyloxyflavone and a monosaccharide derivative. It is functionally related to a baicalein. It is a conjugate acid of a baicalin(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
CAS number
21967-41-9Other or deprecated CAS: 206752-33-2, 31564-28-0
EC numbers
606-866-1, 633-784-3
Molecular formula
C21H18O11
UNII
347Q89U4M5
MDL number
MFCD00134418
INCI name
BAICALIN
InChIKey
IKIIZLYTISPENI-ZFORQUDYSA-N
InChI
InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1
Canonical SMILES
O=C(O)C1OC(Oc2cc3oc(-c4ccccc4)cc(=O)c3c(O)c2O)C(O)C(O)C1O
Isomeric SMILES
C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)O)O

Synonyms

  • Baicalein 7-O-glucuronide
  • Baicalein 7-glucuronide
  • 7-D-Glucuronic acid-5,6-dihydroxyflavone
  • 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid
  • 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid
  • (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
  • 7-D-glucuronic acid-5,6-dihydroxy-flavone
  • beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl
  • 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate
  • (2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
  • Baicalein 7-O-beta-D-glucuronide
  • Baicalin 1000 microg/mL in Methanol
  • 5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide
  • (2S,3S,4S,5R,6R)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
  • (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid
  • (2S,3S,4S,5R,6S)-6-[(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
  • Baicaloside
  • (2S,3S,4S,5R,6S)-6-[(4,6-dihydroxy-5-oxo-2-phenyl-5H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
  • Baicalein-7-O-glucuronide
  • Baicalin CRS
  • Baicalin,(S)
  • Baicalin (Standard)
  • Baicalin, 95%
  • Baicalein 7-beta-D-glucopyranosiduronate
  • baicalein-7-glucuronide
Show all 32 synonyms
  • Baicalein-7-D-glucuronide
  • Baicalein 7-glucuronoside,
  • baicalein-7-o-glucuronic acid
  • Baicalin 7-b-d-glucuronide
  • Baicalin, >=99.0% (HPLC)
  • 7-D-glucuronic acid-5,6-dihydroxy-f
  • compound 15

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
446.36 g/molcalc.
Exact mass
446.0849 Dacalc.
LogP (octanol/water)
0.14calc.
Topological polar surface area
187.1 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
4calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.24calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2cc(OC3CCCCO3)ccc12

O=c1cc(-c2ccccc2)oc2cc(OC3CCCCO3)ccc12

4 rings, 24 atoms.

144 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Baicalin suppliers

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Where suppliers are based

94 suppliers in 14 countries

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Baicalin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name BAICALIN(antioxidant, skin conditioning)

Pharmacological actions

  • Anti-Asthmatic Agents
  • Anti-Infective Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Enzyme Inhibitors

Roles

  • DNA polymerase inhibitor
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antiatherosclerotic agent
  • antibacterial agent
  • anticoronaviral agent
  • antimicrobial agent
  • antineoplastic agent
  • antioxidant
  • antirheumatic drug
  • antiviral agent
  • cardioprotective agent
  • cardiovascular drug
  • enzyme inhibitor
  • eukaryotic metabolite
  • ferroptosis inhibitor
  • metabolite
  • neuroprotective agent
  • non-steroidal anti-inflammatory drug
  • pharmaceutical
  • plant metabolite
  • pro-agent
  • prodrug
  • protective agent

Cosmetic functions

  • Antioxidant
  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Baicalin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Baicalin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Baicalin, based on the data on this page

What is Baicalin?

Baicalin is the glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis.

What is the CAS number of Baicalin?

The CAS registry number of Baicalin is 21967-41-9. Other or deprecated CAS numbers: 206752-33-2, 31564-28-0.

What is the molecular formula and weight of Baicalin?

The molecular formula of Baicalin is C21H18O11 and its molar mass is 446.36 g/mol.

What is Baicalin used for?

Known uses and roles of Baicalin include anti-inflammatories in pharmaceuticals, antibacterials and antibiotics in pharmaceuticals, respiratory and anti-allergy drugs in pharmaceuticals, antioxidants in cosmetics and personal care, skin conditioning agents in cosmetics and personal care and 30 more.

Is Baicalin hazardous?

Baicalin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Baicalin?

Baicalin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Baicalin?

CompoundList lists 94 suppliers of Baicalin in China, United States, United Kingdom, Spain and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Baicalin in India?

1 supplier in India list Baicalin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Baicalin?

Suppliers quote Baicalin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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