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Cardiovascular and metabolic drugs

Bendroflumethiazide

Also known as Bendrofluazide, Naturetin, Aprinox

CAS 73-48-3Formula C15H14F3N3O4S2Molar mass 421.42 g/molEC 200-800-1
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Bendroflumethiazide chemical structure, C15H14F3N3O4S2, CAS 73-48-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from dioxane
Melting point
224.5 to 225.5
Solubility
In water, 108.3 mg/l at 25 °C.
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Bendroflumethiazide?

Plain description, key identifiers and synonyms

Bendroflumethiazide is a sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group. It has a role as a diuretic and an antihypertensive agent. It is a sulfonamide and a benzothiadiazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
CAS number
73-48-3 CAS number cross-checked
EC number
200-800-1
Molecular formula
C15H14F3N3O4S2
UNII
5Q52X6ICJI
MDL number
MFCD00078963
InChIKey
HDWIHXWEUNVBIY-UHFFFAOYSA-N
InChI
InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
SMILES (canonical and isomeric)
C1=CC=C(C=C1)CC2NC3=C(C=C(C(=C3)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N2

Synonyms

  • Bendrofluazide
  • Naturetin
  • Aprinox
  • Benzhydroflumethiazide
  • Benzylrodiuran
  • Centyl
  • Pluryl
  • Bentride
  • Bristuric
  • Bristuron
  • Flumesil
  • Niagaril
  • Plusuril
  • Poliuron
  • Sinesalin
  • Sodiuretic
  • Thiazidico
  • Intolex
  • Orsile
  • Pluryle
  • Repicin
  • Salural
  • Salures
  • Urlea
  • Benzylhydroflumethiazide
Show all 37 synonyms
  • Neo-rontyl
  • Bendroflumetiazida
  • Bendroflumethiazidum
  • Naturine
  • Naturetin-2.5
  • Benzydroflumethiazide
  • Bendroflumetiazide
  • Naturetin-5
  • Naturetin-10
  • Be 724-A
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from dioxaneexp.
Odour
ODORLESS OR HAS SLIGHT, CHARACTERISTIC FLORAL ODORexp.
Melting point
224.5 to 225.5exp.
Solubility
In water, 108.3 mg/l at 25 °C.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
421.42 g/molcalc.
Exact mass
421.0378 Dacalc.
LogP (octanol/water)
1.63calc.
Topological polar surface area
118.4 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
3calc.
Heavy atoms
27calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.2calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S1(=O)NC(Cc2ccccc2)Nc2ccccc21

O=S1(=O)NC(Cc2ccccc2)Nc2ccccc21

3 rings, 19 atoms.

15 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bendroflumethiazide suppliers

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All 47 suppliers
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Where suppliers are based

47 suppliers in 12 countries

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Bendroflumethiazide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Diuretic, antihypertensive.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antihypertensive Agents
  • Diuretics
  • Sodium Chloride Symporter Inhibitors

Roles

  • antihypertensive agent
  • cardiovascular drug
  • diuretic
  • pharmaceutical

Functional uses

  • Pharmaceutical

Pharmacology

Bendroflumethiazide is a Thiazide Diuretic. The physiologic effect of bendroflumethiazide is by means of Increased Diuresis.

How it is made

Prepn: C.T. Holdrege et al., J Am Chem Soc 81, 4807 (1959), F. Lund, W.O. Godtfredsen, Brit pat 863,474, eidem, U.S. pat 3,392,168 (1961, 1968 both to Lovens Kemiske Fabrik).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Bendroflumethiazide (INN) and its derivatives, Ref no: 53, Annex ref: II/53

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bendroflumethiazide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bendroflumethiazide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bendroflumethiazide, based on the data on this page

What is Bendroflumethiazide?

Bendroflumethiazide is a sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group. It has a role as a diuretic and an antihypertensive agent.

What is the CAS number of Bendroflumethiazide?

The CAS registry number of Bendroflumethiazide is 73-48-3.

What is the molecular formula and weight of Bendroflumethiazide?

The molecular formula of Bendroflumethiazide is C15H14F3N3O4S2 and its molar mass is 421.42 g/mol.

What is Bendroflumethiazide used for?

Therapeutic category: Diuretic, antihypertensive. Use classes: Pharmaceuticals.

Is Bendroflumethiazide hazardous?

No GHS hazard classification for Bendroflumethiazide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Bendroflumethiazide?

Bendroflumethiazide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bendroflumethiazide?

CompoundList lists 47 suppliers of Bendroflumethiazide in China, United States, India, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bendroflumethiazide in India?

4 suppliers in India list Bendroflumethiazide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bendroflumethiazide?

Suppliers quote Bendroflumethiazide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bendroflumethiazide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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