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Screening compounds

Benproperine

Also known as Cofrel, benproperina, Benproperinum

CAS 2156-27-6Formula C21H27NOMolar mass 309.45 g/mol
1 supplier listed
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Benproperine chemical structure, C21H27NO, CAS 2156-27-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2156-27-6
Formula
C21H27NO
Molar mass
309.45 g/mol
HS code
293339
Category
Screening compounds

What is Benproperine?

Plain description, key identifiers and synonyms

1-[1-[2-(phenylmethyl)phenoxy]propan-2-yl]piperidine is a diarylmethane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[1-(2-benzylphenoxy)propan-2-yl]piperidine
CAS number
2156-27-6 CAS number cross-checked
Molecular formula
C21H27NO
UNII
3AA6IZ48YK
InChIKey
JTUQXGZRVLWBCR-UHFFFAOYSA-N
InChI
InChI=1S/C21H27NO/c1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19/h2,4-7,10-13,18H,3,8-9,14-17H2,1H3
SMILES (canonical and isomeric)
CC(COC1=CC=CC=C1CC2=CC=CC=C2)N3CCCCC3

Synonyms

  • Cofrel
  • benproperina
  • Benproperinum
  • 1-(2-(2-Benzylphenoxy)-1-methylethyl)piperidine
  • ASA 158/5 FREE BASE
  • ASA-158/5 FREE BASE
  • 1-(1-Methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)piperidine
  • ASA-158-5 free base
  • 1-(1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-piperidine and 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylate) (2:1)
  • 1-[1-(2-benzylphenoxy)propan-2-yl]piperidine
  • Benproperine (INN)
  • Bemproperina
  • Benproperin
  • benproper-inum
  • Cofrel (TN)
  • 1-(2-(2-Benzilfenossi)-1-metiletil)-piperidina
  • Piperidine, 1-(1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-
  • Piperidine, 1-(1-methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)-
  • ASA 158/5
  • 5-20-02-00159 (Beilstein Handbook Reference)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
309.45 g/molcalc.
Exact mass
309.2093 Dacalc.
LogP (octanol/water)
4.53calc.
Topological polar surface area
12.47 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
6calc.
Heavy atoms
23calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1

c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1

3 rings, 22 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Benproperine suppliers

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Where suppliers are based

1 supplier in 1 country

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Benproperine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antitussive
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Benproperine is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Benproperine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Benproperine, based on the data on this page

What is Benproperine?

1-[1-[2-(phenylmethyl)phenoxy]propan-2-yl]piperidine is a diarylmethane.

What is the CAS number of Benproperine?

The CAS registry number of Benproperine is 2156-27-6.

What is the molecular formula and weight of Benproperine?

The molecular formula of Benproperine is C21H27NO and its molar mass is 309.45 g/mol.

What is Benproperine used for?

Known uses and roles of Benproperine include building blocks in research and laboratory, screening compounds in research and laboratory, antitussive and pharmaceutical.

Is Benproperine hazardous?

No GHS hazard classification for Benproperine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Benproperine?

Benproperine is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Benproperine?

CompoundList lists 1 supplier of Benproperine in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Benproperine?

Suppliers quote Benproperine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Benproperine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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