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Screening compounds

Diphenidol

Also known as Difenidol, Nometic, Avomol

CAS 972-02-1Formula C21H27NOMolar mass 309.45 g/molEC 213-540-9
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Diphenidol chemical structure, C21H27NO, CAS 972-02-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Needles from petroleum ether
Melting point
104 to 105 °C
Solubility
CRYSTALS FROM CHLOROFORM + ETHYL ACETATE, FREELY SOL IN METHANOL, SOL IN WATER & CHLOROF…
HS code
293339
Category
Screening compounds
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Diphenidol?

Plain description, key identifiers and synonyms

Diphenidol is a tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4. It has a role as an antiemetic. It is a member of benzenes, a member of piperidines and a tertiary alcohol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,1-diphenyl-4-piperidin-1-ylbutan-1-ol
CAS number
972-02-1 CAS number cross-checkedOther or deprecated CAS: 19-11-4
EC number
213-540-9
Molecular formula
C21H27NO
UNII
NQO8R319LY
InChIKey
OGAKLTJNUQRZJU-UHFFFAOYSA-N
InChI
InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2
SMILES (canonical and isomeric)
C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O

Synonyms

  • Difenidol
  • Nometic
  • Avomol
  • Difenidolo
  • Difenidolum
  • 1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol
  • alpha,alpha-Diphenyl-1-piperidinebutanol
  • Diphenyl(3-(1-piperidyl)propyl)carbinol
  • SKF 478
  • SK&F 478
  • SK&F-478
  • Benzhydrol, alpha-(3-piperidinopropyl)-
  • 1-Piperidinebutanol, alpha,alpha-diphenyl-
  • SK&F-478-J
  • Vontrol
  • diphenadol
  • Difenidol HCl
  • 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol
  • 1,1-Diphenyl-4-piperidino-1-butanol
  • Diphenidol (USAN/INN)
  • 1-Piperidinebutanol, a,a-diphenyl-
  • Difenidol - API Standards
  • SK&F-478A
  • 1H-Indene-5-carboxylic acid,2,3-dihydro-3-oxo-,eth

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Needles from petroleum etherexp.
Odour
ODORLESSexp.
Taste
SLIGHTLY BITTER TASTEexp.
Melting point
104 to 105 °Cexp.
Solubility
CRYSTALS FROM CHLOROFORM + ETHYL ACETATE, FREELY SOL IN METHANOL, SOL IN WATER & CHLOROFORM, PRACTICALLY INSOL IN ETHER, BENZENE, & PETROLEUM ETHER /HCL/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
309.45 g/molcalc.
Exact mass
309.2093 Dacalc.
LogP (octanol/water)
4.19calc.
Topological polar surface area
23.47 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
6calc.
Heavy atoms
23calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C(CCCN2CCCCC2)c2ccccc2)cc1

c1ccc(C(CCCN2CCCCC2)c2ccccc2)cc1

3 rings, 22 atoms, the Piperidine, 1-(4,4-diphenylbutyl)- ring system.

12 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Diphenidol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 3 countries

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Diphenidol price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antiemetics

Roles

  • antiemetic
  • pharmaceutical

Pharmacology

Diphenidol is an Antiemetic. The physiologic effect of diphenidol is by means of Emesis Suppression.

How it is made

Miescher, marxer, us patent 2,411,644 (1946 to ciba), barrett, wilkinson, british patent 683,950 (1952 to wellcome foundation), ca 48, 2112e (1954).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diphenidol is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Diphenidol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diphenidol, based on the data on this page

What is Diphenidol?

Diphenidol is a tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4. It has a role as an antiemetic. It is a member of benzenes, a member of piperidines and a tertiary alcohol.

What is the CAS number of Diphenidol?

The CAS registry number of Diphenidol is 972-02-1. Other or deprecated CAS numbers: 19-11-4.

What is the molecular formula and weight of Diphenidol?

The molecular formula of Diphenidol is C21H27NO and its molar mass is 309.45 g/mol.

What is Diphenidol used for?

Known uses and roles of Diphenidol include building blocks in research and laboratory, screening compounds in research and laboratory, antiemetic, pharmaceutical and antiemetics.

Is Diphenidol hazardous?

No GHS hazard classification for Diphenidol is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Diphenidol?

Diphenidol is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diphenidol?

CompoundList lists 3 suppliers of Diphenidol in China, Germany and Japan. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Diphenidol?

Suppliers quote Diphenidol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diphenidol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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