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Impurities and reference standards

Benzidine dihydrochloride

Also known as Benzidine HCl, [1,1'-Biphenyl]-4,4'-diamine, dihydrochloride, Dihidrocloruro de benzidina

CAS 531-85-1Formula C12H14Cl2N2Molar mass 257.16 g/molEC 208-519-6
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 11 suppliers listed
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Benzidine dihydrochloride chemical structure, C12H14Cl2N2, CAS 531-85-1
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Powder
Melting point
>300
Solubility
1 to 5 mg/mL at 74.3 °F
HS code
292159
Category
Impurities and reference standards
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Benzidine dihydrochloride?

Plain description, key identifiers and synonyms

Benzidine dihydrochloride is a white crystalline powder. (NTP, 1992)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-(4-aminophenyl)aniline, dihydrochloride
CAS number
531-85-1 CAS number cross-checked
EC number
208-519-6
Molecular formula
C12H14Cl2N2
UNII
LVU06XHC39
MDL number
MFCD00040389
InChIKey
RUAXWVDEYJEWRY-UHFFFAOYSA-N
InChI
InChI=1S/C12H12N2.2ClH/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10;;/h1-8H,13-14H2;2*1H
SMILES (canonical and isomeric)
C1=CC(=CC=C1C2=CC=C(C=C2)N)N.Cl.Cl

Synonyms

  • Benzidine HCl
  • [1,1'-Biphenyl]-4,4'-diamine, dihydrochloride
  • Dihidrocloruro de benzidina
  • (1,1'-Biphenyl)-4,4'-diamine, dihydrochloride
  • (1,1'-Biphenyl)-4,4'-diamine, hydrochloride (1:2)
  • (1,1'-Biphenyl)-4,4'-diamine hydrochloride (1:2)
  • Benzidine.2HCl
  • 4-(4-aminophenyl)aniline, dihydrochloride
  • benzidinedihydrochloride
  • Phenylbutazone Impurity A
  • Biphenyl-4,4'-diamine Dihydrochloride (Benzidine Dihydrochloride)
  • biphenyl-4,4'-diamine dihydrochloride
  • benzidine, dihydrochloride
  • Phenylbutazone Impurity N2
  • Benzidine dihydrochloride, >=99% (titration)
  • 4-(4-aminophenyl)phenylamine, chloride, chloride
  • [1,1'-Biphenyl]-4,4'-diamine--hydrogen chloride (1/2)
  • Benzidine dihydrochloride, for experimental carcinogenesis, >=99.0%
  • Biphenyl-4,4'-diamine Dihydrochloride, Phenylbutazone Imp. E (EP) as Dihydrochloride, Benzidine Dihydrochloride, Phenylbutazone Impurity E as Dihydrochloride

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Powderexp.
Melting point
>300exp.
Solubility
1 to 5 mg/mL at 74.3 °Fexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
257.16 g/molcalc.
Exact mass
256.0534 Dacalc.
LogP (octanol/water)
3.36calc.
Topological polar surface area
52.04 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2ccccc2)cc1

c1ccc(-c2ccccc2)cc1

2 rings, 12 atoms, the Biphenyl ring system.

32,228 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H350May cause cancer.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (11)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Benzidine dihydrochloride suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 11 suppliers
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Where suppliers are based

11 suppliers in 4 countries

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Benzidine dihydrochloride price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 612-070-00-5[1]

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Benzidine dihydrochloride, Ref no: 713, Annex ref: II/713

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Significant new use rule

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Benzidine dihydrochloride is traded under.

HS 2921.59Indicative HS code

Aromatic polyamines and their derivatives, salts thereof, other

World exports in 2024
$510M
−0.4% vs 2023, imports $488M
2019 to 2024
Top exporters
  1. China26.6%
  2. Japan16.6%
  3. India * partner reported12.4%
Top importers
  1. United States17.9%
  2. Germany11.6%
  3. South Korea7.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Benzidine dihydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Benzidine dihydrochloride, based on the data on this page

What is Benzidine dihydrochloride?

Benzidine dihydrochloride is a white crystalline powder. (NTP, 1992)

What is the CAS number of Benzidine dihydrochloride?

The CAS registry number of Benzidine dihydrochloride is 531-85-1.

What is the molecular formula and weight of Benzidine dihydrochloride?

The molecular formula of Benzidine dihydrochloride is C12H14Cl2N2 and its molar mass is 257.16 g/mol.

Is Benzidine dihydrochloride hazardous?

Benzidine dihydrochloride carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause cancer, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Benzidine dihydrochloride?

Benzidine dihydrochloride is usually classified under HS code 292159 (Aromatic polyamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Benzidine dihydrochloride?

CompoundList lists 11 suppliers of Benzidine dihydrochloride in China, United States, France and India. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Benzidine dihydrochloride in India?

1 supplier in India list Benzidine dihydrochloride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Benzidine dihydrochloride?

Suppliers quote Benzidine dihydrochloride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Benzidine dihydrochloride

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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