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Buffers and biological buffers

Bicine

Also known as N,N-Bis(2-hydroxyethyl)glycine, Diethylolglycine, Diethanol glycine

CAS 150-25-4Formula C6H13NO4Molar mass 163.17 g/molEC 205-755-1
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Bicine chemical structure, C6H13NO4, CAS 150-25-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
150-25-4
Formula
C6H13NO4
Molar mass
163.17 g/mol
EC number
205-755-1
HS code
292250
Category
Buffers and biological buffers

What is Bicine?

Plain description, key identifiers and synonyms

N,N-bis(2-hydroxyethyl)glycine is a bicine that is a Good's buffer substance, pKa = 8.35 at 20 C. It is a conjugate acid of a [bis(2-hydroxyethyl)amino]acetate. It is a tautomer of a [bis(2-hydroxyethyl)ammonio]acetate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[bis(2-hydroxyethyl)amino]acetic acid
CAS number
150-25-4 CAS number cross-checked
EC number
205-755-1
Molecular formula
C6H13NO4
UNII
1J484QFI1O
MDL number
MFCD00004295
InChIKey
FSVCELGFZIQNCK-UHFFFAOYSA-N
InChI
InChI=1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)
SMILES (canonical and isomeric)
C(CO)N(CCO)CC(=O)O

Synonyms

  • N,N-Bis(2-hydroxyethyl)glycine
  • Diethylolglycine
  • Diethanol glycine
  • Dihydroxyethylglycine
  • Bicene
  • Glycine, N,N-bis(2-hydroxyethyl)-
  • 2-(bis(2-hydroxyethyl)amino)acetic acid
  • N,N-Dihydroxyethyl glycine
  • N,N-Dihydroxyethylglycine
  • DHEG
  • 2-[bis(2-hydroxyethyl)amino]acetic acid
  • di(hydroxyethyl)glycine
  • N,N-Di(2-hydroxyethyl)glycine
  • Bis(2-Hydroxyethyl)glycine
  • Fe-3-Specific
  • N,N-(2-Hydroxyethyl)glycine
  • N,N-Bis(2-hydroxyethyl)aminoacetic acid
  • N,N-(2-Dihydroxyethyl)glycine
  • N,N-Bis(beta-hydroxyethyl)glycine
  • Glycine, N,N-dihydroxyethyl-
  • N,N-Bis(hydroxyethyl)glycine
  • N,N-bis [2-hydroxyethyl]glycine
  • N,N-Dihydroxyethyl
  • bicine buffer
  • Diethanolglycine
Show all 34 synonyms
  • Glycine,N-dihydroxyethyl-
  • Glycine,N-bis(2-hydroxyethyl)-
  • Chelest GA, DHEG, NSC 7342, NSC 7512, Diethanol glycine
  • 2-HxG
  • N,N-di(hydroxyethyl)glycine
  • 4-04-00-02390 (Beilstein Handbook Reference)
  • di(hydroxyethyl)aminoacetic acid
  • BICINE, >=99% (titration)
  • N,N-bis(2-hydroxyethyl)glycine]

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
163.17 g/molcalc.
Exact mass
163.0845 Dacalc.
LogP (octanol/water)
-1.64calc.
Topological polar surface area
81 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
6calc.
Heavy atoms
11calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.83calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Bicine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 30 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

30 suppliers in 7 countries

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Bicine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bicine is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bicine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bicine, based on the data on this page

What is Bicine?

N,N-bis(2-hydroxyethyl)glycine is a bicine that is a Good's buffer substance, pKa = 8.35 at 20 C. It is a conjugate acid of a [bis(2-hydroxyethyl)amino]acetate. It is a tautomer of a [bis(2-hydroxyethyl)ammonio]acetate.

What is the CAS number of Bicine?

The CAS registry number of Bicine is 150-25-4.

What is the molecular formula and weight of Bicine?

The molecular formula of Bicine is C6H13NO4 and its molar mass is 163.17 g/mol.

What is Bicine used for?

Known uses and roles of Bicine include buffers in research and laboratory.

Is Bicine hazardous?

No GHS hazard classification for Bicine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Bicine?

Bicine is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bicine?

CompoundList lists 30 suppliers of Bicine in China, United States, Germany, Hong Kong and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bicine in India?

1 supplier in India list Bicine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bicine?

Suppliers quote Bicine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bicine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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