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Cosmetic antioxidants

Bisdemethoxycurcumin

Also known as Curcumin III, Didemethoxycurcumin, (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

CAS 33171-05-0Formula C19H16O4Molar mass 308.33 g/molEC 607-464-9
GHS signal word: Warning. Pictograms: Harmful or irritant 15 suppliers listed
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Bisdemethoxycurcumin chemical structure, C19H16O4, CAS 33171-05-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
33171-05-0
Formula
C19H16O4
Molar mass
308.33 g/mol
EC number
607-464-9
HS code
291450
Category
Cosmetic antioxidants

What is Bisdemethoxycurcumin?

Plain description, key identifiers and synonyms

Bisdemethoxycurcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups. It has a role as a metabolite and an EC 3.2.1.1 (alpha-amylase) inhibitor. It is a polyphenol, an enone, a beta-diketone and a diarylheptanoid. It is functionally related to a 4-coumaric acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
CAS number
33171-05-0 CAS number cross-checkedOther or deprecated CAS: 22608-12-4, 24939-16-0
EC numbers
607-464-9, 881-423-5
Molecular formula
C19H16O4
UNII
2EFO1BP34R
MDL number
MFCD03419284
INCI name
BIS-DEMETHOXYCURCUMIN
InChIKey
PREBVFJICNPEKM-YDWXAUTNSA-N
InChI
InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
Canonical SMILES
O=C(C=Cc1ccc(O)cc1)CC(=O)C=Cc1ccc(O)cc1
Isomeric SMILES
C1=CC(=CC=C1/C=C/C(=O)CC(=O)/C=C/C2=CC=C(C=C2)O)O

Synonyms

  • Curcumin III
  • Didemethoxycurcumin
  • (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
  • bisdesmethoxycurcumin
  • Bis-demethoxycurcumin
  • Bis(p-hydroxycinnamoyl)methane
  • 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-
  • bisdemethoxy-curcumin
  • Bisdemethoxycucurmin
  • Bis(4-hydroxycinnamoyl)methane
  • (E,E)-Bisdemethoxycurcumin
  • 1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
  • 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-
  • BHCMT
  • di-p-coumaroylmethane
  • Bis-desmethoxycurcumin
  • p,p'-Dihydroxydicinnamoylmethane
  • Curcumin III, Didemethoxycurcumin
  • Curcuminoid A
  • Dide Methoxycurcu Min
  • (E,E)-Curcumin III
  • Bisdemethoxycurcumin [M+H]+
  • BDMC, (E,E)-Curcumin III
  • INS NO.100(III)
  • (1E,6E)-Bisdemethoxycurcumin
Show all 32 synonyms
  • bis(4-hydroxylcinnamoyl)methane
  • INS-100(III)
  • bis(4-hydroxy-cinnamoyl)methane
  • E-100(III)
  • (1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
  • (E,E)-Bisdemethoxycurcumin (Standard)
  • Bisdemethoxycurcumin, analytical standard

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
308.33 g/molcalc.
Exact mass
308.1049 Dacalc.
LogP (octanol/water)
3.35calc.
Topological polar surface area
74.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
6calc.
Heavy atoms
23calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.05calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(C=Cc1ccccc1)CC(=O)C=Cc1ccccc1

O=C(C=Cc1ccccc1)CC(=O)C=Cc1ccccc1

2 rings, 21 atoms.

52 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bisdemethoxycurcumin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 15 suppliers
15 of 15 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

15 suppliers in 6 countries

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Bisdemethoxycurcumin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name BIS-DEMETHOXYCURCUMIN(antioxidant)

Roles

  • enzyme inhibitor
  • metabolite

Functional uses

  • Antioxidant

Cosmetic functions

  • Antioxidant

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bisdemethoxycurcumin is traded under.

HS 2914.50Indicative HS code

Ketone-phenols and ketones with other oxygen function

World exports in 2024
$438M
+10.9% vs 2023, imports $420M
2019 to 2024
Top exporters
  1. China50.5%
  2. India * partner reported11.6%
  3. United States11.3%
Top importers
  1. United States20.8%
  2. Germany10.0%
  3. Netherlands8.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bisdemethoxycurcumin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bisdemethoxycurcumin, based on the data on this page

What is Bisdemethoxycurcumin?

Bisdemethoxycurcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups. It has a role as a metabolite and an EC 3.2.1.1 (alpha-amylase) inhibitor. It is a polyphenol, an enone, a beta-diketone and a diarylheptanoid.

What is the CAS number of Bisdemethoxycurcumin?

The CAS registry number of Bisdemethoxycurcumin is 33171-05-0. Other or deprecated CAS numbers: 22608-12-4, 24939-16-0.

What is the molecular formula and weight of Bisdemethoxycurcumin?

The molecular formula of Bisdemethoxycurcumin is C19H16O4 and its molar mass is 308.33 g/mol.

What is Bisdemethoxycurcumin used for?

Known uses and roles of Bisdemethoxycurcumin include antioxidants in cosmetics and personal care, food colors in food and beverage, enzyme inhibitor, metabolite and antioxidant.

Is Bisdemethoxycurcumin hazardous?

Bisdemethoxycurcumin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bisdemethoxycurcumin?

Bisdemethoxycurcumin is usually classified under HS code 291450 (Ketone-phenols and ketones with other oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bisdemethoxycurcumin?

CompoundList lists 15 suppliers of Bisdemethoxycurcumin in China, United States, India, Czech Republic and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bisdemethoxycurcumin in India?

2 suppliers in India list Bisdemethoxycurcumin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bisdemethoxycurcumin?

Suppliers quote Bisdemethoxycurcumin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bisdemethoxycurcumin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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