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Respiratory, allergy and digestive drugs

Bromhexine

Also known as Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, Bromhexina, Bromhexinum

CAS 3572-43-8Formula C14H20Br2N2Molar mass 376.14 g/molEC 222-684-1
GHS signal word: Warning. Pictograms: Hazardous to the environment 85 suppliers listed Drug substance
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Bromhexine chemical structure, C14H20Br2N2, CAS 3572-43-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3572-43-8
Formula
C14H20Br2N2
Molar mass
376.14 g/mol
EC number
222-684-1
HS code
292159
Category
Respiratory, allergy and digestive drugs

What is Bromhexine?

Plain description, key identifiers and synonyms

Bromhexine is a substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum). It has a role as a mucolytic. It is an organobromine compound, a substituted aniline and a tertiary amino compound. It is a conjugate base of a bromhexine(1+).

Bromhexine is a drug, chemical compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline
CAS number
3572-43-8 CAS number cross-checked
EC number
222-684-1
Molecular formula
C14H20Br2N2
UNII
Q1J152VB1P
MDL number
MFCD00436295
InChIKey
OJGDCBLYJGHCIH-UHFFFAOYSA-N
InChI
InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3
SMILES (canonical and isomeric)
CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2

Synonyms

  • Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-
  • Bromhexina
  • Bromhexinum
  • Fluibron
  • 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline
  • 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline
  • 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
  • N-cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine
  • 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine
  • Bromexina
  • DurElix
  • bromhexin von ct
  • Dur Elix
  • BC, Bromhexin
  • Bromhexinratiopharm
  • Bromhexine, Famel
  • ct, bromhexin von
  • von ct, bromhexin
  • Hustentabsratiopharm
  • Bromhexin ratiopharm
  • Bromhexin-ratiopharm
  • Hustentabs ratiopharm
  • Bromhexin BerlinChemie
  • Bromhexin Berlin Chemie
  • Bromhexin Berlin-Chemie
Show all 33 synonyms
  • Bromexine
  • 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine
  • Bromhexine (INN)
  • Toluene-alpha,2-diamine, 3,5-dibromo-Nalpha-cyclohexyl-Nalpha-methyl-
  • [(2-amino-3,5-dibromophenyl)methyl]cyclohexylmethylamine
  • C14H20Br2N2
  • Fluibron (TN)
  • N-Cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
376.14 g/molcalc.
Exact mass
373.9993 Dacalc.
LogP (octanol/water)
4.56calc.
Topological polar surface area
29.26 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.57calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CNC2CCCCC2)cc1

c1ccc(CNC2CCCCC2)cc1

2 rings, 14 atoms, the Benzenemethanamine, N-cyclohexyl- ring system.

712 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (3)
  • P273Avoid release to the environment.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bromhexine suppliers

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All 85 suppliers
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Where suppliers are based

85 suppliers in 23 countries

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Bromhexine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Expectorants

Roles

  • antiinfective agent
  • antimalarial
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • antiviral agent
  • mucolytic
  • pharmaceutical

Pharmacology

Bromhexine is a secretolytic, with mucolytic activity. Upon administration, bromhexine increases lysosomal activity and enhances hydrolysis of acid mucopolysaccharide polymers in the respiratory tract. This increases the production of serous mucus in the respiratory tract, which makes the phlegm thinner and decreases mucus viscosity. This contributes to its secretomotoric effect, and allows the cilia to more easily transport the phlegm out of the lungs. This clears mucus from the respiratory tract and may aid in the treatment of respiratory disorders associated with abnormal viscid mucus, excessive mucus secretion and impaired mucus transport.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bromhexine is traded under.

HS 2921.59Indicative HS code

Aromatic polyamines and their derivatives, salts thereof, other

World exports in 2024
$510M
−0.4% vs 2023, imports $488M
2019 to 2024
Top exporters
  1. China26.6%
  2. Japan16.6%
  3. India * partner reported12.4%
Top importers
  1. United States17.9%
  2. Germany11.6%
  3. South Korea7.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Bromhexine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bromhexine, based on the data on this page

What is Bromhexine?

Bromhexine is a substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e.

What is the CAS number of Bromhexine?

The CAS registry number of Bromhexine is 3572-43-8.

What is the molecular formula and weight of Bromhexine?

The molecular formula of Bromhexine is C14H20Br2N2 and its molar mass is 376.14 g/mol.

What is Bromhexine used for?

Use classes: Pharmaceuticals.

Is Bromhexine hazardous?

Bromhexine carries the GHS signal word "Warning". Main hazards: very toxic to aquatic life, very toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bromhexine?

Bromhexine is usually classified under HS code 292159 (Aromatic polyamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bromhexine?

CompoundList lists 85 suppliers of Bromhexine in United States, China, India, Bangladesh and 19 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bromhexine in India?

15 suppliers in India list Bromhexine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bromhexine?

Suppliers quote Bromhexine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bromhexine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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