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Indicators and stains

Bromophenol blue

Also known as Bromphenol blue, Albutest, Tetrabromphenol Blue

CAS 115-39-9Formula C19H10Br4O5SMolar mass 669.97 g/molEC 204-086-2
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Bromophenol blue chemical structure, C19H10Br4O5S, CAS 115-39-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Hexagonal prisms from acetic acid and acetone
Melting point
279 ยฐC
Solubility
In water, 3 mg/mL
HS code
293499
Category
Indicators and stains
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Bromophenol blue?

Plain description, key identifiers and synonyms

Bromophenol blue is 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups. It is used as a laboratory indicator, changing from yellow below pH 3 to purple at pH 4.6, and as a size marker for monitoring the progress of agarose gel and polyacrylamide gel electrophoresis. It has also been used as an industrial dye. It has a role as a dye, an acid-base indicator and a two-colour indicator. It is a member of phenols, an organobromine compound, a 2,1-benzoxathiole, a sultone and an arenesulfonate ester.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,6-dibromo-4-[3-(3,5-dibromo-4-hydroxyphenyl)-1,1-dioxo-2,1ฮป6-benzoxathiol-3-yl]phenol
CAS number
115-39-9 CAS number cross-checked
EC number
204-086-2
Molecular formula
C19H10Br4O5S
UNII
0R2969YC90
MDL number
MFCD00005875
INCI name
BROMPHENOL BLUE
InChIKey
UDSAIICHUKSCKT-UHFFFAOYSA-N
InChI
InChI=1S/C19H10Br4O5S/c20-12-5-9(6-13(21)17(12)24)19(10-7-14(22)18(25)15(23)8-10)11-3-1-2-4-16(11)29(26,27)28-19/h1-8,24-25H
SMILES (canonical and isomeric)
C1=CC=C2C(=C1)C(OS2(=O)=O)(C3=CC(=C(C(=C3)Br)O)Br)C4=CC(=C(C(=C4)Br)O)Br

Synonyms

  • Bromphenol blue
  • Albutest
  • Tetrabromphenol Blue
  • 3,3',5,5'-Tetrabromophenolsulfonphthalein
  • 3',3'',5',5''-Tetrabromophenolsulfonephthalein
  • 3',3'',5',5''-Tetrabromophenolsulfophthalein
  • Blue, Bromphenol
  • Blue, Bromophenol
  • Blue, Tetrabromophenol
  • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo)-, S,S-dioxide
  • Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-
  • Bromophenol blue indicator
  • Bromophenol blue indicator (3.0-4.6)
  • Bromphenol Blue Sultone Form
  • bromophenol blue, sultone form
  • Bromophenol Blue, ACS reagent
  • Bromophenol blue (sodium salt)
  • Bromophenol Blue (Technical Grade)
  • Bromophenol Blue, ACS reagent, EP
  • 3,3-bis(3,5-dibromo-4-hydroxyphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide
  • Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-
  • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-, S,S-dioxide
  • Albutest, NSC 7818, Tetrabromophenolsulfophthalein
  • 4,4'-(1,1-Dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromophenol]
  • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-, S,S-dioxide
Show all 34 synonyms
  • 3,3',5,5'-Tetrabromophenolsulfonphthalein, Albutest
  • Brophenol Blue
  • 4,4'-(1,1-Dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromophenol)
  • Bromophenol Blue solution
  • Bromophenol Blue ACS Grade
  • Bromophenol blue solution R2
  • Tetrabromophenolsulfonphthalein
  • 5-19-03-00458 (Beilstein Handbook Reference)
  • Bromophenol Blue, JIS special grade

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Hexagonal prisms from acetic acid and acetoneexp.
Melting point
279 ยฐCexp.
Solubility
In water, 3 mg/mLexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
669.97 g/molcalc.
Exact mass
665.6982 Dacalc.
LogP (octanol/water)
6.16calc.
Topological polar surface area
83.83 ร…ยฒcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.05calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S1(=O)OC(c2ccccc2)(c2ccccc2)c2ccccc21

O=S1(=O)OC(c2ccccc2)(c2ccccc2)c2ccccc21

4 rings, 23 atoms, the 3,3-Diphenyl-3H-benzo[c][1,2]oxathiole 1,1-dioxide ring system.

63 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Bromophenol blue suppliers

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All 36 suppliers
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Where suppliers are based

36 suppliers in 6 countries

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Bromophenol blue price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

As indicator, pH 3.0 yellow, pH 4.6 purple.

Vital dye for vitreoretinal surgery.

Adsorption Indicators. Indicator: bromophenol blue, Titratable ions: Cl, I, Titrant (Reagent): Ag, Color change: yellow - green - greenish blue. (from table).

Vital dye for vitreoretinal surgery.

Cosmetic ingredient, INCI name BROMPHENOL BLUE(antimicrobial, antioxidant)

Pharmacological actions

  • Coloring Agents
  • Indicators and Reagents

Roles

  • acid-base indicator
  • colour indicator
  • dye
  • indicator
  • two-colour indicator
  • visual indicator

Functional uses

  • Antioxidant
  • Biocide

Cosmetic functions

  • Antimicrobial
  • Antioxidant

How it is made

Prepared by slow addition of excess bromine to a hot solution of phenolsulfonphthalein in glacial acetic acid.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bromophenol blue is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Bromophenol blue is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bromophenol blue, based on the data on this page

What is Bromophenol blue?

Bromophenol blue is 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups.

What is the CAS number of Bromophenol blue?

The CAS registry number of Bromophenol blue is 115-39-9.

What is the molecular formula and weight of Bromophenol blue?

The molecular formula of Bromophenol blue is C19H10Br4O5S and its molar mass is 669.97 g/mol.

What is Bromophenol blue used for?

As indicator, pH 3.0 yellow, pH 4.6 purple. Vital dye for vitreoretinal surgery. Adsorption Indicators. Indicator: bromophenol blue, Titratable ions: Cl, I, Titrant (Reagent): Ag, Color change: yellow - green - greenish blue. (from table). Vital dye for vitreoretinal surgery.

Is Bromophenol blue hazardous?

No GHS hazard classification for Bromophenol blue is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Bromophenol blue?

Bromophenol blue is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclicโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bromophenol blue?

CompoundList lists 36 suppliers of Bromophenol blue in India, United States, China, United Kingdom and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bromophenol blue in India?

16 suppliers in India list Bromophenol blue on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bromophenol blue?

Suppliers quote Bromophenol blue on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bromophenol blue

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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