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Dyes and pigments

Bromothymol blue

Also known as Bromthymol blue, Dibromothymolsulfophthalein, Dibromothymolsulfonphthalein

CAS 76-59-5Formula C27H28Br2O5SMolar mass 624.39 g/molEC 200-971-2
GHS signal word: Warning. Pictograms: Harmful or irritant 51 suppliers listed
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Bromothymol blue chemical structure, C27H28Br2O5S, CAS 76-59-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
76-59-5
Formula
C27H28Br2O5S
Molar mass
624.39 g/mol
EC number
200-971-2
HS code
293499
Category
Dyes and pigments

What is Bromothymol blue?

Plain description, key identifiers and synonyms

Bromothymol blue is a member of the class of 2,1-benzoxathioles that is 2,1-benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3-bromo-4-hydroxy-5-isopropyl-2-methylphenyl groups. It has a role as a dye, an acid-base indicator and a two-colour indicator. It is a polyphenol, an organobromine compound, a 2,1-benzoxathiole, a sultone and an arenesulfonate ester.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-bromo-4-[3-(3-bromo-4-hydroxy-2-methyl-5-propan-2-ylphenyl)-1,1-dioxo-2,1ฮป6-benzoxathiol-3-yl]-3-methyl-6-propan-2-ylphenol
CAS number
76-59-5 CAS number cross-checked
EC number
200-971-2
Molecular formula
C27H28Br2O5S
UNII
VGU4LM0H96
MDL number
MFCD00005872
INCI name
BROMOTHYMOL BLUE
InChIKey
NUHCTOLBWMJMLX-UHFFFAOYSA-N
InChI
InChI=1S/C27H28Br2O5S/c1-13(2)17-11-20(15(5)23(28)25(17)30)27(19-9-7-8-10-22(19)35(32,33)34-27)21-12-18(14(3)4)26(31)24(29)16(21)6/h7-14,30-31H,1-6H3
SMILES (canonical and isomeric)
CC1=C(C=C(C(=C1Br)O)C(C)C)C2(C3=CC=CC=C3S(=O)(=O)O2)C4=C(C(=C(C(=C4)C(C)C)O)Br)C

Synonyms

  • Bromthymol blue
  • Dibromothymolsulfophthalein
  • Dibromothymolsulfonphthalein
  • Thymol, 6,6'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-, S,S-dioxide
  • Blue, Bromthymol
  • Blue, Bromothymol
  • Thymol, 6,6'-(3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-, S,S-dioxide
  • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-methylethyl))-, S,S-dioxide
  • 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-met-hylethyl)phenol) S,S-dioxide
  • 3,3'-Dibromothymolsulfonphthalein
  • Bromthymolblau
  • 3,3-Bis(3-bromo-4-hydroxy-5-isopropyl-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide
  • Bromothymol blue (sodium salt)
  • 3',3''-Dibromothymolsulfonphthalein
  • Phenol,4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-3-methyl-6-(1-methylethyl)-
  • 2-bromo-4-[3-(3-bromo-4-hydroxy-2-methyl-5-propan-2-ylphenyl)-1,1-dioxo-2,1lambda6-benzoxathiol-3-yl]-3-methyl-6-propan-2-ylphenol
  • Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-methylethyl)-
  • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-methylethyl)-, S,S-dioxide
  • 3,3-bis[3-bromo-4-hydroxy-2-methyl-5-(propan-2-yl)phenyl]-3H-2,1??-benzoxathiole-1,1-dione
  • Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-3-methyl-6-(1-methylethyl)-, S,S-dioxide
  • C27H28Br2O5S
  • Dibromothymolsulfophthalein, 3,3'-Dibromothymolsulfonphthalein
  • Azul de bromotimol
  • Blu di bromotimolo
  • 3,3-bis[3-bromo-4-hydroxy-2-methyl-5-(methylethyl)phenyl]benzo[c]1,2-oxathiole ne-1,1-dione
Show all 35 synonyms
  • Bleu de bromothymol
  • Bromothymol blue free acid
  • Dibromothymolsulphonphthalein
  • bromothymol sulfone phthalein
  • Bromothymol blue solution R1
  • 5-19-03-00461 (Beilstein Handbook Reference)
  • Bromothymol Blue, ACS reagent
  • Bromothymol blue indicator ph.eur
  • 3,3'-Dibromothymolsulfonephthalein
  • 3, 3'-Dibromothymolsulfonphthalein

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
624.39 g/molcalc.
Exact mass
622.0024 Dacalc.
LogP (octanol/water)
7.5calc.
Topological polar surface area
83.83 ร…ยฒcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
35calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S1(=O)OC(c2ccccc2)(c2ccccc2)c2ccccc21

O=S1(=O)OC(c2ccccc2)(c2ccccc2)c2ccccc21

4 rings, 23 atoms, the 3,3-Diphenyl-3H-benzo[c][1,2]oxathiole 1,1-dioxide ring system.

63 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (13)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Bromothymol blue suppliers

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All 51 suppliers
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Where suppliers are based

51 suppliers in 9 countries

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Bromothymol blue price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Cosmetics.

Cosmetic ingredient, INCI name BROMOTHYMOL BLUE(colorant)

Pharmacological actions

  • Coloring Agents
  • Indicators and Reagents

Roles

  • acid-base indicator
  • colour indicator
  • dye
  • indicator
  • two-colour indicator
  • visual indicator

Functional uses

  • Dye

Cosmetic functions

  • Colorant

Pharmacology

Bromthymol Blue is a dye used as an indicator in determining pH. Bromthymol blue is a weak acid. It can be in acid or base form, depending on the pH of the solution. This reagent is yellow in acidic solutions, blue in basic solutions and green in neutral solution.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex IV, allowed colourant
    Name: BROMOTHYMOL BLUE, Ref no: 151, Annex ref: IV/151

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Bromothymol blue is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Bromothymol blue is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Bromothymol blue, based on the data on this page

What is Bromothymol blue?

Bromothymol blue is a member of the class of 2,1-benzoxathioles that is 2,1-benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3-bromo-4-hydroxy-5-isopropyl-2-methylphenyl groups. It has a role as a dye, an acid-base indicator and a two-colour indicator.

What is the CAS number of Bromothymol blue?

The CAS registry number of Bromothymol blue is 76-59-5.

What is the molecular formula and weight of Bromothymol blue?

The molecular formula of Bromothymol blue is C27H28Br2O5S and its molar mass is 624.39 g/mol.

What is Bromothymol blue used for?

Use classes: Cosmetics.

Is Bromothymol blue hazardous?

Bromothymol blue carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Bromothymol blue?

Bromothymol blue is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclicโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Bromothymol blue?

CompoundList lists 51 suppliers of Bromothymol blue in India, United States, China, Czech Republic and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Bromothymol blue in India?

18 suppliers in India list Bromothymol blue on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Bromothymol blue?

Suppliers quote Bromothymol blue on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Bromothymol blue

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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