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Central nervous system drugs

Buspirone

Also known as Buspirona, Ansial, Buspironum

CAS 36505-84-7Formula C21H31N5O2Molar mass 385.51 g/molEC 253-072-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 65 suppliers listed Drug substance
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Buspirone chemical structure, C21H31N5O2, CAS 36505-84-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
36505-84-7
Formula
C21H31N5O2
Molar mass
385.51 g/mol
EC number
253-072-2
HS code
293359
Category
Central nervous system drugs

What is Buspirone?

Plain description, key identifiers and synonyms

Buspirone is an azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N4 position. It has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is an azaspiro compound, an organic heteropolycyclic compound, a member of pyrimidines, a N-alkylpiperazine, a N-arylpiperazine and a member of piperidones. It is a conjugate base of a buspirone(1+).

Buspirone is a medication used to treat anxiety disorders.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
CAS number
36505-84-7 CAS number cross-checkedOther or deprecated CAS: 116753-41-4
EC number
253-072-2
Molecular formula
C21H31N5O2
UNII
TK65WKS8HL
InChIKey
QWCRAEMEVRGPNT-UHFFFAOYSA-N
InChI
InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
SMILES (canonical and isomeric)
C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4

Synonyms

  • Buspirona
  • Ansial
  • Buspironum
  • Gen-Buspirone
  • Bespar
  • 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione
  • 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
  • 8-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione
  • 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione
  • 8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-
  • 8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-
  • 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-
  • ratio Buspirone
  • Novo Buspirone
  • Apo Buspirone
  • Gen Buspirone
  • Lin Buspirone
  • Nu Buspirone
  • PMS Buspirone
  • 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro(4.5)decane-7,9-dione
  • 8-(4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl)-8-azaspiro(4.5)decane-7,9-dione
  • N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide
  • Buspirone free base
  • buspin
  • Buspirone (INN)
Show all 33 synonyms
  • 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione
  • 8-Azaspiro[4.5]decane-7,9-dione,8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-
  • Buspirone-MDTS
  • Gen-Buspirone (TN)
  • Buspirone, 8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]- (9CI)
  • YLX
  • Buspirone (Standard)
  • Tocris-0962

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
385.51 g/molcalc.
Exact mass
385.2478 Dacalc.
LogP (octanol/water)
2.09calc.
Topological polar surface area
69.64 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
6calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.71calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1

O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1

4 rings, 28 atoms. This chemical is the scaffold itself.

22 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Buspirone suppliers

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All 65 suppliers
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Where suppliers are based

65 suppliers in 15 countries

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Buspirone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Anti-Anxiety Agents
  • Serotonin Receptor Agonists

Roles

  • antidepressant
  • antidyskinesia agent
  • antiparkinson drug
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • enzyme inhibitor
  • gastrointestinal drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • sedative
  • serotonergic agonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Buspirone is an anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Buspirone is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Buspirone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Buspirone, based on the data on this page

What is Buspirone?

Buspirone is an azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N4 position.

Is Buspirone hazardous?

Buspirone carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

Guides for buyers

Practical guides that help when you source, ship or handle Buspirone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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