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Murcko scaffold

Buspirone scaffold

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
23
With full pages
7
Scaffold SMILES

O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Buspirone page
Murcko scaffold O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

Buspirone chemical structure, C21H31N5O2, CAS 36505-84-7
Buspirone
CAS 36505-84-7C21H31N5O2
Buspirone hydrochloride chemical structure, C21H32ClN5O2, CAS 33386-08-2
Buspirone hydrochloride
CAS 33386-08-2C21H32ClN5O2
6-Hydroxybuspirone, (6R)- chemical structure, C21H31N5O3, CAS 477930-30-6
6-Hydroxybuspirone, (6R)-
CAS 477930-30-6C21H31N5O3
6-Hydroxybuspirone chemical structure, C21H31N5O3, CAS 125481-61-0
6-Hydroxybuspirone
CAS 125481-61-0C21H31N5O3
(±)-6-Hydroxybuspirone hydrochloride chemical structure, C21H32ClN5O3, CAS 2108825-99-4
(±)-6-Hydroxybuspirone hydrochloride
CAS 2108825-99-4C21H32ClN5O3
6-Hydroxybuspirone, (6S)- chemical structure, C21H31N5O3, CAS 477930-31-7
6-Hydroxybuspirone, (6S)-
CAS 477930-31-7C21H31N5O3
8-{4-[4-(5-Fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl}-8-aza-spiro[4.5]decane-7,9-dione chemical structure, C21H30FN5O2, CAS 92972-49-1
8-{4-[4-(5-Fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butyl}-8-aza-spiro[4.5]decane-7,9-dione
CAS 92972-49-1C21H30FN5O2
Buspirone N-oxide chemical structure, C21H31N5O3, CAS 220747-81-9
Buspirone N-oxide
CAS 220747-81-9C21H31N5O3
8-[1,1,2,2,3,3,4,4-Octadeuterio-4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione, hydrochloride chemical structure, C21H32ClN5O2, CAS 1216761-39-5
8-[1,1,2,2,3,3,4,4-Octadeuterio-4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione, hydrochloride
CAS 1216761-39-5C21H32ClN5O2
8-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl-1,1,2,2,3,3,4,4-d8)-8-azaspiro(4.5)decane-7,9-dione chemical structure, C21H31N5O2, CAS 204395-49-3
8-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl-1,1,2,2,3,3,4,4-d8)-8-azaspiro(4.5)decane-7,9-dione
CAS 204395-49-3C21H31N5O2
6-Hydroxy buspirone-d8 chemical structure, C21H31N5O3, CAS 1189644-16-3
6-Hydroxy buspirone-d8
CAS 1189644-16-3C21H31N5O3
5-Hydroxy buspirone chemical structure, C21H31N5O3, CAS 105496-33-1
5-Hydroxy buspirone
CAS 105496-33-1C21H31N5O3
6,10-Dihydroxy buspirone chemical structure, C21H31N5O4, CAS 658701-59-8
6,10-Dihydroxy buspirone
CAS 658701-59-8C21H31N5O4
6,10-Dihydroxy buspirone-d8 chemical structure, C21H31N5O4, CAS 1346599-17-4
6,10-Dihydroxy buspirone-d8
CAS 1346599-17-4C21H31N5O4
5-Hydroxy buspirone-d8 chemical structure, C21H31N5O3, CAS 1330164-16-3
5-Hydroxy buspirone-d8
CAS 1330164-16-3C21H31N5O3
4-Methoxy-5-hydroxy-buspirone chemical structure, C22H33N5O4, CAS 125498-82-0
4-Methoxy-5-hydroxy-buspirone
CAS 125498-82-0C22H33N5O4
6-Hydroxybuspirone hydrochloride, (6R)- chemical structure, C21H32ClN5O3, CAS 2108486-86-6
6-Hydroxybuspirone hydrochloride, (6R)-
CAS 2108486-86-6C21H32ClN5O3
6-Hydroxybuspirone hydrochloride, (6S)- chemical structure, C21H32ClN5O3, CAS 2108875-94-9
6-Hydroxybuspirone hydrochloride, (6S)-
CAS 2108875-94-9C21H32ClN5O3
5,6'-Dihydroxybuspirone chemical structure, C21H31N5O4, CAS 125481-59-6
5,6'-Dihydroxybuspirone
CAS 125481-59-6C21H31N5O4
4-Methoxy-5,6'-dihydroxy-buspirone chemical structure, C22H33N5O5, CAS 125481-60-9
4-Methoxy-5,6'-dihydroxy-buspirone
CAS 125481-60-9C22H33N5O5
8-(4-(4-(5-Chloropyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro(4.5)decane-7,9-dione chemical structure, C21H30ClN5O2, CAS 2725354-99-2
8-(4-(4-(5-Chloropyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro(4.5)decane-7,9-dione
CAS 2725354-99-2C21H30ClN5O2
Buspirone N-oxide oxalate chemical structure, C23H33N5O7, CAS 1797880-63-7
Buspirone N-oxide oxalate
CAS 1797880-63-7C23H33N5O7
Buspirone impurity 43 chemical structure, C21H31N5O3, CAS 220747-82-0
Buspirone impurity 43
CAS 220747-82-0C21H31N5O3