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Cardiovascular and metabolic drugs

Canrenone

Also known as Aldadiene, Canrenonum, Spironolactone metabolite m1

CAS 976-71-6Formula C22H28O3Molar mass 340.46 g/molEC 213-554-5
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 22 suppliers listed
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Canrenone chemical structure, C22H28O3, CAS 976-71-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
976-71-6
Formula
C22H28O3
Molar mass
340.46 g/mol
EC number
213-554-5
HS code
293220
Category
Cardiovascular and metabolic drugs

What is Canrenone?

Plain description, key identifiers and synonyms

Canrenone is a steroid lactone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
CAS number
976-71-6 CAS number cross-checked
EC number
213-554-5
Molecular formula
C22H28O3
UNII
78O20X9J0U
MDL number
MFCD00071735
InChIKey
UJVLDDZCTMKXJK-WNHSNXHDSA-N
InChI
InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
Canonical SMILES
CC12CCC(=O)C=C1C=CC1C2CCC2(C)C1CCC21CCC(=O)O1
Isomeric SMILES
C[C@]12CCC(=O)C=C1C=C[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]45CCC(=O)O5)C

Synonyms

  • Aldadiene
  • Canrenonum
  • Spironolactone metabolite m1
  • Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (17alpha)-
  • (1'S,2R,2'R,10'R,11'S,15'S)-2',15'-dimethylspiro(oxolane-2,14'-tetracyclo(8.7.0.0^(2,7).0^(11,15))heptadecane)-6',8'-diene-5,5'-dione
  • (1'S,2R,2'R,10'R,11'S,15'S)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-6',8'-diene-5,5'-dione
  • R.P., 11614
  • Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone, (17alpha)-
  • SC 9376
  • Phanurane
  • Luvion
  • Canrenona
  • (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
  • Canrenone (USAN)
  • 17-Hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactone
  • Aldadiene (VAN)
  • (10R,13S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
  • (2'R,8R,9S,10R,13S,14S)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
  • 11614 R. P.
  • Aldadiene, SC9376, SC14266
  • Spiroletan
  • Spironolactone EP impurity F
  • Eplerenone Impurity - Canrenone, Spironolactone EP Impurity F
  • 11614 R.P
  • Phanurane,
Show all 34 synonyms
  • Contaren,
  • Canrenone CRS
  • Luvion,
  • 20-Spiroxa-4,6-diene-3,21-dione
  • 3',4'-Dihydrospiro[androst-4,6-diene-17,2'(5'H)-furan]-3,5'-dione (Canrenone)
  • (2\'R,8R,9S,10R,13S,14S)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3\'H-spiro[cyclopenta[a]phenanthrene-17,2\'-furan]-3,5\'(2H,4\'H)-dione
  • (8R,9S,10R,13S,14S,17R)-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
  • Canrenone (Standard)
  • Canrenone - 95%

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
340.46 g/molcalc.
Exact mass
340.2038 Dacalc.
LogP (octanol/water)
4.37calc.
Topological polar surface area
43.37 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
0calc.
Heavy atoms
25calc.
Rings
5calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.73calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2C=CC3C(CCC4C3CCC43CCC(=O)O3)C2CC1

O=C1C=C2C=CC3C(CCC4C3CCC43CCC(=O)O3)C2CC1

5 rings, 23 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H351Suspected of causing cancer.
  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Canrenone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 22 suppliers
22 of 22 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

22 suppliers in 7 countries

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Canrenone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Mineralocorticoid Receptor Antagonists

Roles

  • cardiovascular drug
  • pharmaceutical

Functional uses

  • Pharmaceutical

Pharmacology

Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. Canrenone is the primary active metabolite of both spironolactone and canreonate potassium.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Canrenone is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Canrenone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Canrenone, based on the data on this page

What is Canrenone?

Canrenone is a steroid lactone.

What is the CAS number of Canrenone?

The CAS registry number of Canrenone is 976-71-6.

What is the molecular formula and weight of Canrenone?

The molecular formula of Canrenone is C22H28O3 and its molar mass is 340.46 g/mol.

What is Canrenone used for?

Use classes: Pharmaceuticals.

Is Canrenone hazardous?

Canrenone carries the GHS signal word "Warning". Main hazards: harmful in contact with skin, harmful if inhaled, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Canrenone?

Canrenone is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Canrenone?

CompoundList lists 22 suppliers of Canrenone in China, United States, India, Hong Kong and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Canrenone in India?

3 suppliers in India list Canrenone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Canrenone?

Suppliers quote Canrenone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Canrenone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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