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Analgesics and anti-inflammatories

Capsaicin

Also known as Zostrix, Capsaicine, trans-Capsaicin

CAS 404-86-4Formula C18H27NO3Molar mass 305.42 g/molEC 206-969-8
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe), Harmful or irritant 132 suppliers listed Drug substance
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Capsaicin chemical structure, C18H27NO3, CAS 404-86-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Pure dark red solid
Melting point
65 °C
Boiling point
210 to 220
Flash point
113 °C
Solubility
Practically insoluble in cold water
HS code
292429
Category
Analgesics and anti-inflammatories
Illustrative photo, red pigment powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Capsaicin?

Plain description, key identifiers and synonyms

Capsaicin is a capsaicinoid. It has a role as a TRPV1 agonist, a non-narcotic analgesic and a voltage-gated sodium channel blocker.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
CAS number
404-86-4 CAS number cross-checkedOther or deprecated CAS: 1217899-52-9
EC number
206-969-8
Molecular formula
C18H27NO3
UNII
S07O44R1ZM
MDL number
MFCD00017259
INCI name
CAPSAICIN
InChIKey
YKPUWZUDDOIDPM-SOFGYWHQSA-N
InChI
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
Canonical SMILES
COc1cc(CNC(=O)CCCCC=CC(C)C)ccc1O
Isomeric SMILES
CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC

Synonyms

  • Zostrix
  • Capsaicine
  • trans-Capsaicin
  • Qutenza
  • Styptysat
  • Axsain
  • Ausanil
  • Isodecenoic acid vanillylamide
  • trans-8-Methyl-N-vanillyl-6-nonenamide
  • Mioton
  • Dolenon
  • Ovocap
  • (E)-8-Methyl-N-vanillyl-6-nonenamide
  • Capzasin-hp
  • 8-Methyl-N-Vanillyl-6-Nonenamide
  • Togarashi orenji
  • ALGRX 4975
  • Ratden pe 40
  • NGX 4010
  • Capsaicina
  • (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
  • Zostrix HP
  • Cntx-4975
  • (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
  • (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Show all 39 synonyms
  • 6-Nonenamide, 8-methyl-N-vanillyl-, (E)-
  • N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-trans-6-enamide
  • ALGRX-4975
  • 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6E)-
  • (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide
  • 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (6E)-
  • Zacin
  • Capsaicin Patch
  • capsaicinum
  • Capsacin
  • Capsadyn
  • Capsimide
  • Neuriterx
  • Neuritrx

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Pure dark red solidexp.
Odour
Highly volatile with a pungent odorexp.
Taste
Burning taste detectable in 1 part in 100,000exp.
Melting point
65 °Cexp.
Boiling point
210 to 220exp.
Flash point
113 °Cexp.
Solubility
Practically insoluble in cold waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
305.42 g/molcalc.
Exact mass
305.1991 Dacalc.
LogP (octanol/water)
3.79calc.
Topological polar surface area
58.56 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
9calc.
Heavy atoms
22calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H318Causes serious eye damage.
Precautionary statements (15)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Capsaicin suppliers

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All 132 suppliers
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Where suppliers are based

132 suppliers in 19 countries

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Capsaicin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Food flavoring, in pepper spray self-defense devices, as a tool in neurobiological research.

For use on fruits, vegetables, foliage plants and ornamentals to repel rabbits, squirrels, and soft-bodied insects.

Biochemical pesticide, animal and insect repellent, pests repelled: birds, moles, deer, dogs, insects, rabbits, squirrels.

Use classes: Pharmaceuticals.

Cosmetic ingredient, INCI name CAPSAICIN(fragrance, skin conditioning)

Pharmacological actions

  • Antipruritics
  • Sensory System Agents

Roles

  • TRPV1 agonist
  • agonist
  • analgesic
  • anti-HIV agent
  • anti-inflammatory agent
  • antiemetic
  • antihypertensive agent
  • antimicrobial agent
  • antineoplastic agent
  • antitussive
  • antiviral agent
  • biophysical role
  • cardiovascular drug
  • membrane transport modulator
  • neuroprotective agent
  • non-narcotic analgesic
  • pharmaceutical
  • protective agent
  • sodium channel blocker
  • sodium channel modulator
  • voltage-gated sodium channel blocker

Functional uses

  • Deodorizer
  • Flavouring and nutrient
  • Fragrance
  • Pharmaceutical
  • Softener and conditioner

Cosmetic functions

  • Fragrance
  • Skin conditioning

Pharmacology

Capsaicin is a chili pepper extract with analgesic properties. Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons. Used topically, capsaicin aids in controlling peripheral nerve pain. This agent has been used experimentally to manipulate substance P and other tachykinins. In addition, capsaicin may be useful in controlling chemotherapy- and radiotherapy-induced mucositis.

How it is made

Reaction of vanillylamine with 7-methyloct-5-ene-1-carboxylic acid chloride, biosynthesis from Capsicum frutescens (red peppers)

The active ingredient capsaicin (oleoresin of Capsicum) is generally obtained by grinding dried ripe fruits of Capsicum frutescens L. (chili peppers) into a fine powder. The oleoresin may be obtained by distillation of the powder in an appropriate solvent, and evaporation of the solvent to yield the liquid oleoresin and associated fatty matter. The fatty matter is removed by decanting or filtration. ...

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Capsaicin is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Capsaicin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Capsaicin, based on the data on this page

What is Capsaicin?

Capsaicin is a capsaicinoid. It has a role as a TRPV1 agonist, a non-narcotic analgesic and a voltage-gated sodium channel blocker.

What is the CAS number of Capsaicin?

The CAS registry number of Capsaicin is 404-86-4. Other or deprecated CAS numbers: 1217899-52-9.

What is the molecular formula and weight of Capsaicin?

The molecular formula of Capsaicin is C18H27NO3 and its molar mass is 305.42 g/mol.

What is Capsaicin used for?

Food flavoring, in pepper spray self-defense devices, as a tool in neurobiological research. For use on fruits, vegetables, foliage plants and ornamentals to repel rabbits, squirrels, and soft-bodied insects.

Is Capsaicin hazardous?

Capsaicin carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Capsaicin?

Capsaicin is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Capsaicin?

CompoundList lists 132 suppliers of Capsaicin in China, United States, India, United Kingdom and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Capsaicin in India?

20 suppliers in India list Capsaicin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Capsaicin?

Suppliers quote Capsaicin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Capsaicin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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